<strong>Background:</strong><span style="font-family:""><span style="font-family:Verdana;"> Breast cancer is the most common cancer diagnosed worldwide, synchronous bil...<strong>Background:</strong><span style="font-family:""><span style="font-family:Verdana;"> Breast cancer is the most common cancer diagnosed worldwide, synchronous bilateral breast cancer accounts for </span><span style="font-family:Verdana;">unique</span><span style="font-family:Verdana;"> entity of the disease, particularly post-operative radiotherapy for Synchronous Bilateral Breast Cancer (SBBC) is challenging with </span><span style="font-family:Verdana;">lack</span><span style="font-family:Verdana;"> of evidence about the best irradiation technique. In this </span><span style="font-family:Verdana;">study</span></span><span style="font-family:Verdana;">,</span><span style="font-family:""><span style="font-family:Verdana;"> we tried to explore the optimum radiotherapy technique regarding the dosimetric parameters. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> We recruited 15 SBBC patients in whom </span><span style="font-family:Verdana;">post-operative</span><span style="font-family:Verdana;"> radiotherapy was indicated and we established three plans for each patient using 3DCRT, IMRT </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> VMAT, and then we compared the three plans as regard target volume coverage parameters and organs at risk (OAR) doses. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> We found that PTV coverage parameter was superior with IMRT compared with 3DCRT and VMAT in terms of Dmean (p = 0.001), D95% (p = 0.001), D</span><sub><span style="font-family:Verdana;">max</span></sub><span style="font-family:Verdana;"> (p = 0.0001), conformity index (p = 0.0001) and HI (p = 0.0001). Doses to OAR w</span></span><span style="font-family:Verdana;">ere</span><span style="font-family:""><span style="font-family:Verdana;"> not significantly different between the three techniques in </span><span style="font-family:Verdana;">cardiac</span><span style="font-family展开更多
文摘<strong>Background:</strong><span style="font-family:""><span style="font-family:Verdana;"> Breast cancer is the most common cancer diagnosed worldwide, synchronous bilateral breast cancer accounts for </span><span style="font-family:Verdana;">unique</span><span style="font-family:Verdana;"> entity of the disease, particularly post-operative radiotherapy for Synchronous Bilateral Breast Cancer (SBBC) is challenging with </span><span style="font-family:Verdana;">lack</span><span style="font-family:Verdana;"> of evidence about the best irradiation technique. In this </span><span style="font-family:Verdana;">study</span></span><span style="font-family:Verdana;">,</span><span style="font-family:""><span style="font-family:Verdana;"> we tried to explore the optimum radiotherapy technique regarding the dosimetric parameters. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> We recruited 15 SBBC patients in whom </span><span style="font-family:Verdana;">post-operative</span><span style="font-family:Verdana;"> radiotherapy was indicated and we established three plans for each patient using 3DCRT, IMRT </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> VMAT, and then we compared the three plans as regard target volume coverage parameters and organs at risk (OAR) doses. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> We found that PTV coverage parameter was superior with IMRT compared with 3DCRT and VMAT in terms of Dmean (p = 0.001), D95% (p = 0.001), D</span><sub><span style="font-family:Verdana;">max</span></sub><span style="font-family:Verdana;"> (p = 0.0001), conformity index (p = 0.0001) and HI (p = 0.0001). Doses to OAR w</span></span><span style="font-family:Verdana;">ere</span><span style="font-family:""><span style="font-family:Verdana;"> not significantly different between the three techniques in </span><span style="font-family:Verdana;">cardiac</span><span style="font-family
