The lander of China’s Chang’E-3 spacecraft is equipped with a 15-cm telescope that is very useful for monitoring celestial objects in the ultraviolet(UV) band(245–340 nm).The Lunar-based Ultraviolet Telescope(LUT) ...The lander of China’s Chang’E-3 spacecraft is equipped with a 15-cm telescope that is very useful for monitoring celestial objects in the ultraviolet(UV) band(245–340 nm).The Lunar-based Ultraviolet Telescope(LUT) is the first long-term lunar-based astronomical observatory,that can make uninterrupted observations of a target from the Moon.Here we present the continuous complete UV light curve of the eclipsing binary TX Herculis(TX Her).The analysis of the light curve suggests that TX Her is a detached binary.The dip in the light curve was explained by the emergence of a stellar dark spot on the less massive F0 type component.The cyclic change of arrival eclipse times for the system reveals that it contains an additional stellar companion with a minimal mass of 0.35 M⊙ and a period of 48.92 yr,which is supported by the detected light contribution of the third body from light curve analysis.This third body may play an important role in the formation of the present short-period system TX Her.展开更多
The stabilizing conditions of W/O microemulsion of Tx 6～C 4H 9OH/c C 6H 12 /H 2O system were studied by visual observation. The result shows that when the weight ratio of Tx 6 to C 4H 9OH is 4∶1,the W/O...The stabilizing conditions of W/O microemulsion of Tx 6～C 4H 9OH/c C 6H 12 /H 2O system were studied by visual observation. The result shows that when the weight ratio of Tx 6 to C 4H 9OH is 4∶1,the W/O microemulsion system has stabilizing and extensive regions, and the system is insensitive to the values of pH and in the range of room temperature.In accordance with the theoretical value of HLB,the suitable value of HLB for Tx 6 and C 4H 9OH to compose microemulsion is greater than 9,less than or equal to 10.展开更多
Wilson disease(WD),known as hepatolenticular degeneration(HLD),is a treatable autosomal recessive disorder of copper metabolism.Because copper deposits in the liver first,the liver is not only the original defective o...Wilson disease(WD),known as hepatolenticular degeneration(HLD),is a treatable autosomal recessive disorder of copper metabolism.Because copper deposits in the liver first,the liver is not only the original defective organ but also the most affected organ.The liver injury is also one of the main causes of death throughout the course of the disease.Therefore,the treatment of liver injury is the main task of WD treatment,which is of great significance to improve the prognosis of patients.Autophagy is a process that promotes cell survival through degradation,recycling,and absorption in order to maintain the normal physiological function of cells,while excessive autophagy can aggravate cell death.In view of the abnormal damage of liver cells in patients with WD,which may be related to the change of autophagy level,in this study,we established an animal model of WD through toxic milk(TX)mice,observed the change of autophagy level in the liver,and observed the change of liver damage in mice after treatment with autophagy inhibitors.It was found that the mTOR signaling pathway was activated and autophagy was inhibited in Wilson mouse liver.After treatment with rapamycin,the autophagy level of mice liver was upregulated,and the copper content of mice liver was reduced,and the damage was alleviated.TX mouse hepatocytes were isolated,after using siRNA to interfere with mTOR expression,the copper accumulation was significantly reduced,which was the same with RAPA treatment.The results showed that in TX mice,the damage caused by copper accumulation in the liver may be related to the decrease of autophagy level caused by the activation of the mTOR signaling pathway.Our findings suggested that RAPA or the use of siRNA targeting mTOR may have potential applications in the treatment of Wilson’s disease.展开更多
TX-SR502是ONKYO(安桥)推出不久的最新款入门级AV接收机.当5.1声道的Dolby Digital和DTS分别发展出6.1声道的Dolby Digital EX和DTS-ES之后,各大主流AV功放(接收机)制造商便依据产品档次的不同,通常在中低档型号上配备5.1声道模式,而在...TX-SR502是ONKYO(安桥)推出不久的最新款入门级AV接收机.当5.1声道的Dolby Digital和DTS分别发展出6.1声道的Dolby Digital EX和DTS-ES之后,各大主流AV功放(接收机)制造商便依据产品档次的不同,通常在中低档型号上配备5.1声道模式,而在中高级产品中才加入6.1声道模式.不过呢,近两年由于竞争激烈,新功能、新技术从高端产品向低端产品移植的速度加快了许多,纵观各大AV品牌,目前除保留一款最低价位的5.1声道AV功放来满足市场最底部的需求之外,其它中低档产品都无一例外地将6.1声道作为了标准配置,而中高级产品则以7.1乃至9.1声道、更多样化的DSP音场模式以及提高功放输出功率来拉开档次差距.展开更多
基金supported by the National Natural Science Foundation of China (Grant Nos. 11573063 and 11611530685)the Key Science Foundation of Yunnan Province (Grant No. 2017FA001)+1 种基金CAS “Light of West China” ProgramCAS Interdisciplinary Innovation Team
文摘The lander of China’s Chang’E-3 spacecraft is equipped with a 15-cm telescope that is very useful for monitoring celestial objects in the ultraviolet(UV) band(245–340 nm).The Lunar-based Ultraviolet Telescope(LUT) is the first long-term lunar-based astronomical observatory,that can make uninterrupted observations of a target from the Moon.Here we present the continuous complete UV light curve of the eclipsing binary TX Herculis(TX Her).The analysis of the light curve suggests that TX Her is a detached binary.The dip in the light curve was explained by the emergence of a stellar dark spot on the less massive F0 type component.The cyclic change of arrival eclipse times for the system reveals that it contains an additional stellar companion with a minimal mass of 0.35 M⊙ and a period of 48.92 yr,which is supported by the detected light contribution of the third body from light curve analysis.This third body may play an important role in the formation of the present short-period system TX Her.
文摘The stabilizing conditions of W/O microemulsion of Tx 6～C 4H 9OH/c C 6H 12 /H 2O system were studied by visual observation. The result shows that when the weight ratio of Tx 6 to C 4H 9OH is 4∶1,the W/O microemulsion system has stabilizing and extensive regions, and the system is insensitive to the values of pH and in the range of room temperature.In accordance with the theoretical value of HLB,the suitable value of HLB for Tx 6 and C 4H 9OH to compose microemulsion is greater than 9,less than or equal to 10.
基金supported by Natural Science Foundation of Anhui Province(1908085MH266)National Natural Science Foundation of China(81673948).
文摘Wilson disease(WD),known as hepatolenticular degeneration(HLD),is a treatable autosomal recessive disorder of copper metabolism.Because copper deposits in the liver first,the liver is not only the original defective organ but also the most affected organ.The liver injury is also one of the main causes of death throughout the course of the disease.Therefore,the treatment of liver injury is the main task of WD treatment,which is of great significance to improve the prognosis of patients.Autophagy is a process that promotes cell survival through degradation,recycling,and absorption in order to maintain the normal physiological function of cells,while excessive autophagy can aggravate cell death.In view of the abnormal damage of liver cells in patients with WD,which may be related to the change of autophagy level,in this study,we established an animal model of WD through toxic milk(TX)mice,observed the change of autophagy level in the liver,and observed the change of liver damage in mice after treatment with autophagy inhibitors.It was found that the mTOR signaling pathway was activated and autophagy was inhibited in Wilson mouse liver.After treatment with rapamycin,the autophagy level of mice liver was upregulated,and the copper content of mice liver was reduced,and the damage was alleviated.TX mouse hepatocytes were isolated,after using siRNA to interfere with mTOR expression,the copper accumulation was significantly reduced,which was the same with RAPA treatment.The results showed that in TX mice,the damage caused by copper accumulation in the liver may be related to the decrease of autophagy level caused by the activation of the mTOR signaling pathway.Our findings suggested that RAPA or the use of siRNA targeting mTOR may have potential applications in the treatment of Wilson’s disease.
文摘TX-SR502是ONKYO(安桥)推出不久的最新款入门级AV接收机.当5.1声道的Dolby Digital和DTS分别发展出6.1声道的Dolby Digital EX和DTS-ES之后,各大主流AV功放(接收机)制造商便依据产品档次的不同,通常在中低档型号上配备5.1声道模式,而在中高级产品中才加入6.1声道模式.不过呢,近两年由于竞争激烈,新功能、新技术从高端产品向低端产品移植的速度加快了许多,纵观各大AV品牌,目前除保留一款最低价位的5.1声道AV功放来满足市场最底部的需求之外,其它中低档产品都无一例外地将6.1声道作为了标准配置,而中高级产品则以7.1乃至9.1声道、更多样化的DSP音场模式以及提高功放输出功率来拉开档次差距.
