We have modified the previously described one-pot peptide synthesis method. The modified method has been successfully applied to the synthesis of TP3. Furthermore, the immune regulatory activity of TP3 has been charac...We have modified the previously described one-pot peptide synthesis method. The modified method has been successfully applied to the synthesis of TP3. Furthermore, the immune regulatory activity of TP3 has been characterized. The results show that the modified one-pot method can be used to synthesize the biological active peptide with the advantages of low cost and high productivity. Moreover, TP3 has a higher immune regulatory activity than TP5.展开更多
Recently, crowdsourcing platforms have attracted a number of citizens to perform a variety of location- specific tasks. However, most existing approaches consider the arrangement of a set of tasks for a set of crowd w...Recently, crowdsourcing platforms have attracted a number of citizens to perform a variety of location- specific tasks. However, most existing approaches consider the arrangement of a set of tasks for a set of crowd workers, while few consider crowd workers arriving in a dynamic manner. Therefore, how to arrange suitable location-specific tasks to a set of crowd workers such that the crowd workers obtain maximum satisfaction when arriving sequentially represents a challenge. To address the limitation of existing approaches, we first identify a more general and useful model that considers not only the arrangement of a set of tasks to a set of crowd workers, but also all the dynamic arrivals of all crowd workers. Then, we present an effective crowd-task model which is applied to offiine and online settings, respectively. To solve the problem in an offiine setting, we first observe the characteristics of task planning （CTP） and devise a CTP algorithm to solve the problem. We also propose an effective greedy method and integrated simulated annealing （ISA） techniques to improve the algorithm performance. To solve the problem in an online setting, we develop a greedy algorithm for task planning. Finally, we verify the effectiveness and efficiency of the proposed solutions through extensive experiments using real and synthetic datasets.展开更多
Objective: To evaluate the role of class III β-tubulin (TUBB3), thymidylate synthase (TS), thymidine phosphorylase (TP), and excision repair cross-complementing group 1 (ERCC1) in clinical outcome of advanced gastric...Objective: To evaluate the role of class III β-tubulin (TUBB3), thymidylate synthase (TS), thymidine phosphorylase (TP), and excision repair cross-complementing group 1 (ERCC1) in clinical outcome of advanced gastric cancer patients receiving capecitabine plus paclitaxel or cisplatin. Methods: The clinical data and tumor specimens from 57 advanced gastric cancer patients receiving first-line capecitabine plus paclitaxel (cohort 1, n=36) and capecitabine plus cisplatin (cohort 2, n=21) were retrospectively collected, and TUBB3, TS, TP, and ERCC1 expressions were detected by real-time quantitative PCR. The associations between expressions of biomarkers and response or survival were analyzed statistically. Results: The median age of 57 patients was 57 years (range: 27–75 years) with 38 males and 19 females. Of all patients, the response rates of patients with high TP, low TP and high TS, low TS expressions were 57.1%, 27.6% (P=0.024), and 55.2%, 28.6% (P=0.042), respectively. Among cohort 1, the response rates and median overall survivals of patients with low and high TUBB3 expressions were 61.1% vs. 33.3% (P=0.095) and 13.8 months vs. 6.6 months (P=0.019), respectively; the response rate (87.5%) of patients with low TUBB3 and high TP expressions was higher than that (14.3%) of patients with high TUBB3 and low TP expressions (P=0.01). Among cohort 2, the response rates of patients with low ERCC1 and high ERCC1 expressions were 45.5% and 20.0% respectively (P=0.361). Conclusion: TUBB3, TS and TP expressions could predict the response of advanced gastric cancer patients receiving capecitabine-based and paclitaxel-based chemotherapy. These results will be further confirmed in future large samples.展开更多
文摘We have modified the previously described one-pot peptide synthesis method. The modified method has been successfully applied to the synthesis of TP3. Furthermore, the immune regulatory activity of TP3 has been characterized. The results show that the modified one-pot method can be used to synthesize the biological active peptide with the advantages of low cost and high productivity. Moreover, TP3 has a higher immune regulatory activity than TP5.
基金supported by the National High-Tech R&D Program(863) of China(No.2014AA015203)
文摘Recently, crowdsourcing platforms have attracted a number of citizens to perform a variety of location- specific tasks. However, most existing approaches consider the arrangement of a set of tasks for a set of crowd workers, while few consider crowd workers arriving in a dynamic manner. Therefore, how to arrange suitable location-specific tasks to a set of crowd workers such that the crowd workers obtain maximum satisfaction when arriving sequentially represents a challenge. To address the limitation of existing approaches, we first identify a more general and useful model that considers not only the arrangement of a set of tasks to a set of crowd workers, but also all the dynamic arrivals of all crowd workers. Then, we present an effective crowd-task model which is applied to offiine and online settings, respectively. To solve the problem in an offiine setting, we first observe the characteristics of task planning （CTP） and devise a CTP algorithm to solve the problem. We also propose an effective greedy method and integrated simulated annealing （ISA） techniques to improve the algorithm performance. To solve the problem in an online setting, we develop a greedy algorithm for task planning. Finally, we verify the effectiveness and efficiency of the proposed solutions through extensive experiments using real and synthetic datasets.
基金supported by the National "863" High‐Tech Res & Dev Program of China (No. 2006AA02A402)Beijing Municipal Science & Technology Commission Program "Optimization of pharmacotherapy and individual selection in gastric cancer" (No D101100050010023)
文摘Objective: To evaluate the role of class III β-tubulin (TUBB3), thymidylate synthase (TS), thymidine phosphorylase (TP), and excision repair cross-complementing group 1 (ERCC1) in clinical outcome of advanced gastric cancer patients receiving capecitabine plus paclitaxel or cisplatin. Methods: The clinical data and tumor specimens from 57 advanced gastric cancer patients receiving first-line capecitabine plus paclitaxel (cohort 1, n=36) and capecitabine plus cisplatin (cohort 2, n=21) were retrospectively collected, and TUBB3, TS, TP, and ERCC1 expressions were detected by real-time quantitative PCR. The associations between expressions of biomarkers and response or survival were analyzed statistically. Results: The median age of 57 patients was 57 years (range: 27–75 years) with 38 males and 19 females. Of all patients, the response rates of patients with high TP, low TP and high TS, low TS expressions were 57.1%, 27.6% (P=0.024), and 55.2%, 28.6% (P=0.042), respectively. Among cohort 1, the response rates and median overall survivals of patients with low and high TUBB3 expressions were 61.1% vs. 33.3% (P=0.095) and 13.8 months vs. 6.6 months (P=0.019), respectively; the response rate (87.5%) of patients with low TUBB3 and high TP expressions was higher than that (14.3%) of patients with high TUBB3 and low TP expressions (P=0.01). Among cohort 2, the response rates of patients with low ERCC1 and high ERCC1 expressions were 45.5% and 20.0% respectively (P=0.361). Conclusion: TUBB3, TS and TP expressions could predict the response of advanced gastric cancer patients receiving capecitabine-based and paclitaxel-based chemotherapy. These results will be further confirmed in future large samples.
