Simulations were performed to examine the effects of a coiled tube after a T-junction on the mixing and flow characteristics. A coiled tube was found to have two effects: inducing a radial flow and flattening the axia...Simulations were performed to examine the effects of a coiled tube after a T-junction on the mixing and flow characteristics. A coiled tube was found to have two effects: inducing a radial flow and flattening the axial velocity distribution, which enhances and weakens the mixing, respectively. In the straight tube section connecting the Tjunction and coiled tube, the latter may dominate and cause the mixing to deteriorate. An experiment was performed with the Villermaux/Dushman method to verify the simulation results. Based on a mixing performance simulation with various fluid and geometric structure parameters, a dimensionless correlation was obtained that can be used to determine the mixing intensity along the coiled tube with a deviation of less than 1.5%.These results provide guidance for designing a coiled tube or optimizing the operating conditions to meet the mixing requirements of specific chemical processes.展开更多
A frequency mixing system including microwave coupling and intermediate frequency (IF) measurement arrangements is designed. In lieu of liquid nitrogen, a pulse tube cryocooler is used to cool the whole system. With Y...A frequency mixing system including microwave coupling and intermediate frequency (IF) measurement arrangements is designed. In lieu of liquid nitrogen, a pulse tube cryocooler is used to cool the whole system. With YBa2Cu3O7/Yttrium stabilized zirconia (YBCO/YSZ) bicry-stal Josephson junction as the mixing element, 36th harmonic frequency mixing at the 8 mm waveband is obtained.展开更多
对微通道反溶剂沉淀法制备白藜芦醇(RES)纳米药物分散体进行了研究。采用T型微通道反应器优化操作参数制备RES纳米分散体,当RES溶液与反溶剂水溶液进料流量比为1∶20(分别为3 m L/min和60 m L/min),RES溶液水平进料时,制得的RES纳米分...对微通道反溶剂沉淀法制备白藜芦醇(RES)纳米药物分散体进行了研究。采用T型微通道反应器优化操作参数制备RES纳米分散体,当RES溶液与反溶剂水溶液进料流量比为1∶20(分别为3 m L/min和60 m L/min),RES溶液水平进料时,制得的RES纳米分散体尺寸最小,平均粒径为132 nm;此时RES纳米分散体接触角为19°,水润湿性较原料药得到大幅度提高;在拟肠液(p H 7.4)环境下,RES纳米分散体在120 min内累积释放率可达到95%。在上述优化工艺的基础上利用套管式微通道反应器进行放大实验,得到套管式微通道反应器制备的RES纳米分散体颗粒尺寸更小,平均粒径为82 nm;在拟肠液环境下,所得RES纳米分散体在120 min内累积释放率可达到97%,略高于T型微通道反应器所得产品的溶出量。计算结果表明,套管式微通道反应器可显著提高处理量,约为T型微通道反应器处理量的10倍。展开更多
基金Supported by the National Natural Science Foundation of China(21422603,U166212)the National Science and Technology Support Program of China(2011BAC06B01)
文摘Simulations were performed to examine the effects of a coiled tube after a T-junction on the mixing and flow characteristics. A coiled tube was found to have two effects: inducing a radial flow and flattening the axial velocity distribution, which enhances and weakens the mixing, respectively. In the straight tube section connecting the Tjunction and coiled tube, the latter may dominate and cause the mixing to deteriorate. An experiment was performed with the Villermaux/Dushman method to verify the simulation results. Based on a mixing performance simulation with various fluid and geometric structure parameters, a dimensionless correlation was obtained that can be used to determine the mixing intensity along the coiled tube with a deviation of less than 1.5%.These results provide guidance for designing a coiled tube or optimizing the operating conditions to meet the mixing requirements of specific chemical processes.
基金This work was supported by the Ministry of Science and Technology of China (Grant No. G19990646).
文摘A frequency mixing system including microwave coupling and intermediate frequency (IF) measurement arrangements is designed. In lieu of liquid nitrogen, a pulse tube cryocooler is used to cool the whole system. With YBa2Cu3O7/Yttrium stabilized zirconia (YBCO/YSZ) bicry-stal Josephson junction as the mixing element, 36th harmonic frequency mixing at the 8 mm waveband is obtained.
文摘对微通道反溶剂沉淀法制备白藜芦醇(RES)纳米药物分散体进行了研究。采用T型微通道反应器优化操作参数制备RES纳米分散体,当RES溶液与反溶剂水溶液进料流量比为1∶20(分别为3 m L/min和60 m L/min),RES溶液水平进料时,制得的RES纳米分散体尺寸最小,平均粒径为132 nm;此时RES纳米分散体接触角为19°,水润湿性较原料药得到大幅度提高;在拟肠液(p H 7.4)环境下,RES纳米分散体在120 min内累积释放率可达到95%。在上述优化工艺的基础上利用套管式微通道反应器进行放大实验,得到套管式微通道反应器制备的RES纳米分散体颗粒尺寸更小,平均粒径为82 nm;在拟肠液环境下,所得RES纳米分散体在120 min内累积释放率可达到97%,略高于T型微通道反应器所得产品的溶出量。计算结果表明,套管式微通道反应器可显著提高处理量,约为T型微通道反应器处理量的10倍。
