The immunoregulating effect of Interleukin-1-receptor antagonist (ILlra ) in lupus-like NZB/W F, mice was investigated to find possible approach to prevent lupus nephritis. 12 female NZB/W F1 mice of 13 weeks were ran...The immunoregulating effect of Interleukin-1-receptor antagonist (ILlra ) in lupus-like NZB/W F, mice was investigated to find possible approach to prevent lupus nephritis. 12 female NZB/W F1 mice of 13 weeks were randomly divlded into 2 groups. Each mouse in the treated group was intraperitoneally injected wlth IL-lra once every 2 weeks for 3 times at the dosage of 100μg each time,while the control group was given injection of 0.1 ml normal saline. All the mice were killed at the age of 9 months and the irnmunologic function was examined.Results showed that this dosage could not completely prevent the development of lupus nephritis, but the renal damage was alleviated and the urine protein was decreased. Moreover, it could improve the immunofunction by significantly reducing the levels of serum IL-1 and obviously increase the activities of NK celIs and IL-2 induced by ConA in mononuclear cells of spleen. There was no significant difference in the levels of serum IL-6 and TNF-α between the treated group and control group. It is concluded that IL-lra has certain regulatory effect on the immunologic function of lupus-like NZB/W F, mice.展开更多
文摘目的 探讨血红蛋白/红细胞计数(MCH)、红细胞计数/白细胞计数(RWR)、血小板计数/白细胞计数(PWR)、C3/球蛋白(C3GR)、C3/尿素氮(C3BR)、C4/尿素氮(C4BR)对系统性红斑狼疮(SLE)疾病活动度的预测价值.方法 选择该院2015-2018年收治的138例S L E患者作为研究对象.按S L E活动度评分表(SLEDAI)评分标准将上述患者分为活动期组(n=71例,SLEDAI≥5分)与静止期组(n=67例,SLEDAI为0~4分).检测患者红细胞沉降率(ESR)、C3、C4、球蛋白、尿素氮、尿蛋白、肝功能、肾功能等指标,比较两组上述指标的差异,计算各指标与SLEDAI评分的相关性.结果 活动期组患者MCH、RWR、PWR、C3GR、C3BR、C4BR与静止期组比较,差异有统计学意义(P<0.05).同时,MCH(r=-0.265)、RWR(r=-0.184)、PWR(r=-0.218)、C3GR(r=-0.461)、C3BR(r=-0.485)、C4BR(r=-0.431)与SLEDAI呈负相关(P<0.05).受试者工作特征曲线(ROC曲线)结果显示,MCH、RWR、PWR、C3GR、C3BR与C4BR诊断SLE活动度的曲线下面积(AUC)分别0.679、0.630、0.614、0.790、0.824和0.784.结论 MCH、RWR、PWR、C3GR、C3BR及C4BR可以作为SLE活动度的辅助诊断指标,有助于疾病活动度的快速判断.
文摘The immunoregulating effect of Interleukin-1-receptor antagonist (ILlra ) in lupus-like NZB/W F, mice was investigated to find possible approach to prevent lupus nephritis. 12 female NZB/W F1 mice of 13 weeks were randomly divlded into 2 groups. Each mouse in the treated group was intraperitoneally injected wlth IL-lra once every 2 weeks for 3 times at the dosage of 100μg each time,while the control group was given injection of 0.1 ml normal saline. All the mice were killed at the age of 9 months and the irnmunologic function was examined.Results showed that this dosage could not completely prevent the development of lupus nephritis, but the renal damage was alleviated and the urine protein was decreased. Moreover, it could improve the immunofunction by significantly reducing the levels of serum IL-1 and obviously increase the activities of NK celIs and IL-2 induced by ConA in mononuclear cells of spleen. There was no significant difference in the levels of serum IL-6 and TNF-α between the treated group and control group. It is concluded that IL-lra has certain regulatory effect on the immunologic function of lupus-like NZB/W F, mice.
