目的探究支撑导管在前臂桡动脉-头静脉内瘘(RC-AVF)手术中的应用及其价值。方法回顾性分析2020年6月至10月在连云港市第一人民医院行RC-AVF手术造瘘60例患者的临床资料。采用改良端侧吻合法的30例为对照组,在对照组基础上联合支撑导管...目的探究支撑导管在前臂桡动脉-头静脉内瘘(RC-AVF)手术中的应用及其价值。方法回顾性分析2020年6月至10月在连云港市第一人民医院行RC-AVF手术造瘘60例患者的临床资料。采用改良端侧吻合法的30例为对照组,在对照组基础上联合支撑导管的30例为试验组,分析比较两组术中相关指标、动静脉内瘘相关指标及使用情况、术后6个月内并发症情况。结果试验组术中血管吻合时间显著短于对照组(P<0.01);首次透析血流量、术后8周引流静脉内径、肱动脉血流量均优于对照组(P<0.05,P<0.01);术后6个月内试验组并发症发生率较对照组有所降低,但差异无统计学意义(7.14% vs 26.92%,P>0.05)。结论在RC-AVF术中使用支撑导管行血管吻合可以不剥离血管外膜,从而减少手术损伤、降低血管吻合难度,且支撑导管成本低廉,获取及使用方便。展开更多
The distal end of the spinal cord and neuromuscular junction may develop secondary degeneration and damage following spinal cord injury because of the loss of neural connections. In this study, a rat model of spinal c...The distal end of the spinal cord and neuromuscular junction may develop secondary degeneration and damage following spinal cord injury because of the loss of neural connections. In this study, a rat model of spinal cord injury, established using a modified Allen＇s method, was injected with basic fibroblast growth factor solution via subarachnoid catheter. After injection, rats with spinal cord injury displayed higher scores on the Basso, Beattie and Bresnahan locomotor scale. Motor function was also well recovered and hematoxylin-eosin staining showed that spinal glial scar hyperplasia was not apparent. Additionally, anterior tibial muscle fibers slowly, but progressively, atrophied. Immu- nohistochemical staining showed that the absorbance values of calcitonin gene related peptide and acetylcholinesterase in anterior tibial muscle and spinal cord were similar, and injection of basic fi- broblast growth factor increased this absorbance. Results showed that after spinal cord injury, the distal motor neurons and motor endplate degenerated. Changes in calcitonin gene related peptide and acetylcholinesterase in the spinal cord anterior horn motor neurons and motor endplate then occurred that were consistent with this regeneration. Our findings indicate that basic fibroblast growth factor can protect the endplate through gene related peptide and acetylcholinesterase cord. attenuating the decreased expression of calcitonin n anterior horn motor neurons of the injured spinal展开更多
目的:探讨晚期肿瘤静脉营养支持患者应用改良型中等长度导管(Midline catheters)与经外周静脉置入中心静脉导管(peripherally inserted central catheter,PICC)应用比较。方法:选取2019年1月至2019年12月就诊于中国人民解放军联勤保障...目的:探讨晚期肿瘤静脉营养支持患者应用改良型中等长度导管(Midline catheters)与经外周静脉置入中心静脉导管(peripherally inserted central catheter,PICC)应用比较。方法:选取2019年1月至2019年12月就诊于中国人民解放军联勤保障部队第904医院血液肿瘤科的晚期肿瘤静脉营养支持患者100例,随机等分为观察组和对照组,观察组采用改良型中等长度导管进行静脉输液,对照组采用PICC进行静脉输液。比较两组患者置管后导管相关并发症的发生情况和一次性置管成功率,同时对两组患者导管相关医疗费用与患者置管满意度进行比较。结果:观察组患者导管相关并发症的发生次数明显低于对照组(P<0.05)。观察组置管和维护费用均较对照组明显减少(P<0.05)。观察组一次性置管成功率和患者置管满意度均明显高于对照组。结论:改良型中等长度导管在晚期肿瘤静脉营养支持患者中的应用效果优于PICC,其并发症少,医疗费用相对较少,置管成功率高及患者满意度高。展开更多
目的研究颅内支撑导管辅助Solitaire支架取栓抽吸技术(SWIM)在急性颅脑大血管闭塞治疗中的效果。方法选取太和县人民医院2020年11月~2022年5月收治的90例急性颅脑大血管闭塞患者,采取随机数字表法分为观察组与对照组,各45例。观察组给予...目的研究颅内支撑导管辅助Solitaire支架取栓抽吸技术(SWIM)在急性颅脑大血管闭塞治疗中的效果。方法选取太和县人民医院2020年11月~2022年5月收治的90例急性颅脑大血管闭塞患者,采取随机数字表法分为观察组与对照组,各45例。观察组给予SWIM取栓术,对照组给予单纯支架取栓术。术后,采用脑梗死溶栓(TICI)治疗分级标准评估血管再通情况;分别于术前及术后1周采用美国国立卫生研究院卒中量表(NIHSS)评估神经缺损情况,Barthel量表评估患者日常生活自理能力;分别于术前及术后1周检测比较两组神经功能指标[神经元特异性烯醇化酶(NSE)、脑源性神经营养因子(BDNF)、S100β蛋白(S100β)]水平;术后随访3个月,采用改良Rankin量表(mRs)评估患者预后,记录两组患者并发症和死亡情况。结果观察组血管再通率(95.56%,4345)明显高于对照组(68.89%,3145),差异有统计学意义(χ^(2)=10.946,P<0.05)。术后1周,观察组NIHSS评分、NSE、S100β水平较对照组低[(5.37±1.09)分vs.(6.24±1.22)分、(6.03±0.92)ng ml vs.(8.18±1.17)ng ml、(0.27±0.07)ng ml vs.(0.35±0.09)ng ml],观察组Barthel评分、BDNF水平较对照组高[(79.06±8.72)分vs.(69.14±8.09)分、(4776.51±508.65)pg ml vs.(4022.39±425.33)pg ml],差异有统计学意义(t=3.567、9.690、4.707、5.594、7.630,P<0.05)。术后3个月,观察组mRs评分低于对照组,差异有统计学意义(χ^(2)=5.344,P<0.05);两组并发症发生率和死亡率近似,差异无统计学意义(χ^(2)=0.549、0.714,P>0.05)。结论SWIM取栓术能够较好恢复急性颅脑大血管闭塞患者的血流灌注,改善其神经缺损,提高其生活自理能力,同时可改善患者预后。展开更多
文摘目的探究支撑导管在前臂桡动脉-头静脉内瘘(RC-AVF)手术中的应用及其价值。方法回顾性分析2020年6月至10月在连云港市第一人民医院行RC-AVF手术造瘘60例患者的临床资料。采用改良端侧吻合法的30例为对照组,在对照组基础上联合支撑导管的30例为试验组,分析比较两组术中相关指标、动静脉内瘘相关指标及使用情况、术后6个月内并发症情况。结果试验组术中血管吻合时间显著短于对照组(P<0.01);首次透析血流量、术后8周引流静脉内径、肱动脉血流量均优于对照组(P<0.05,P<0.01);术后6个月内试验组并发症发生率较对照组有所降低,但差异无统计学意义(7.14% vs 26.92%,P>0.05)。结论在RC-AVF术中使用支撑导管行血管吻合可以不剥离血管外膜,从而减少手术损伤、降低血管吻合难度,且支撑导管成本低廉,获取及使用方便。
基金supported by a grant from the Hunan Provincial Science and Technology Ministry in China, No. 2012SK3222Funding for New Teachers by the Ministry of Education in China, No. 200805331166
文摘The distal end of the spinal cord and neuromuscular junction may develop secondary degeneration and damage following spinal cord injury because of the loss of neural connections. In this study, a rat model of spinal cord injury, established using a modified Allen＇s method, was injected with basic fibroblast growth factor solution via subarachnoid catheter. After injection, rats with spinal cord injury displayed higher scores on the Basso, Beattie and Bresnahan locomotor scale. Motor function was also well recovered and hematoxylin-eosin staining showed that spinal glial scar hyperplasia was not apparent. Additionally, anterior tibial muscle fibers slowly, but progressively, atrophied. Immu- nohistochemical staining showed that the absorbance values of calcitonin gene related peptide and acetylcholinesterase in anterior tibial muscle and spinal cord were similar, and injection of basic fi- broblast growth factor increased this absorbance. Results showed that after spinal cord injury, the distal motor neurons and motor endplate degenerated. Changes in calcitonin gene related peptide and acetylcholinesterase in the spinal cord anterior horn motor neurons and motor endplate then occurred that were consistent with this regeneration. Our findings indicate that basic fibroblast growth factor can protect the endplate through gene related peptide and acetylcholinesterase cord. attenuating the decreased expression of calcitonin n anterior horn motor neurons of the injured spinal
文摘目的:探讨晚期肿瘤静脉营养支持患者应用改良型中等长度导管(Midline catheters)与经外周静脉置入中心静脉导管(peripherally inserted central catheter,PICC)应用比较。方法:选取2019年1月至2019年12月就诊于中国人民解放军联勤保障部队第904医院血液肿瘤科的晚期肿瘤静脉营养支持患者100例,随机等分为观察组和对照组,观察组采用改良型中等长度导管进行静脉输液,对照组采用PICC进行静脉输液。比较两组患者置管后导管相关并发症的发生情况和一次性置管成功率,同时对两组患者导管相关医疗费用与患者置管满意度进行比较。结果:观察组患者导管相关并发症的发生次数明显低于对照组(P<0.05)。观察组置管和维护费用均较对照组明显减少(P<0.05)。观察组一次性置管成功率和患者置管满意度均明显高于对照组。结论:改良型中等长度导管在晚期肿瘤静脉营养支持患者中的应用效果优于PICC,其并发症少,医疗费用相对较少,置管成功率高及患者满意度高。
文摘目的研究颅内支撑导管辅助Solitaire支架取栓抽吸技术(SWIM)在急性颅脑大血管闭塞治疗中的效果。方法选取太和县人民医院2020年11月~2022年5月收治的90例急性颅脑大血管闭塞患者,采取随机数字表法分为观察组与对照组,各45例。观察组给予SWIM取栓术,对照组给予单纯支架取栓术。术后,采用脑梗死溶栓(TICI)治疗分级标准评估血管再通情况;分别于术前及术后1周采用美国国立卫生研究院卒中量表(NIHSS)评估神经缺损情况,Barthel量表评估患者日常生活自理能力;分别于术前及术后1周检测比较两组神经功能指标[神经元特异性烯醇化酶(NSE)、脑源性神经营养因子(BDNF)、S100β蛋白(S100β)]水平;术后随访3个月,采用改良Rankin量表(mRs)评估患者预后,记录两组患者并发症和死亡情况。结果观察组血管再通率(95.56%,4345)明显高于对照组(68.89%,3145),差异有统计学意义(χ^(2)=10.946,P<0.05)。术后1周,观察组NIHSS评分、NSE、S100β水平较对照组低[(5.37±1.09)分vs.(6.24±1.22)分、(6.03±0.92)ng ml vs.(8.18±1.17)ng ml、(0.27±0.07)ng ml vs.(0.35±0.09)ng ml],观察组Barthel评分、BDNF水平较对照组高[(79.06±8.72)分vs.(69.14±8.09)分、(4776.51±508.65)pg ml vs.(4022.39±425.33)pg ml],差异有统计学意义(t=3.567、9.690、4.707、5.594、7.630,P<0.05)。术后3个月,观察组mRs评分低于对照组,差异有统计学意义(χ^(2)=5.344,P<0.05);两组并发症发生率和死亡率近似,差异无统计学意义(χ^(2)=0.549、0.714,P>0.05)。结论SWIM取栓术能够较好恢复急性颅脑大血管闭塞患者的血流灌注,改善其神经缺损,提高其生活自理能力,同时可改善患者预后。
