BACKGROUND Unstable carotid atherosclerotic plaques are prone to cause ischemic stroke.Contrast-enhanced ultrasound(CEUS) is the primary method of assessing plaque stability, but CEUS cannot be a method for screening ...BACKGROUND Unstable carotid atherosclerotic plaques are prone to cause ischemic stroke.Contrast-enhanced ultrasound(CEUS) is the primary method of assessing plaque stability, but CEUS cannot be a method for screening for unstable plaque. The emergence of superb micro-vascular imaging(SMI) offers the possibility of clinically screening for unstable plaque AIM To investigate the value of SMI in predicting ischemic stroke in patients with carotid atherosclerotic plaques.METHODS Patients with carotid atherosclerotic plaques(luminal stenosis of 50%-70%) were enrolled into the present study. All patients received conservative medication.The patient's clinical baseline data, serological data, CEUS and SMI data were analyzed. All patients underwent a 3-year follow-up. The follow-up endpoint was the occurrence of ischemic stroke and patients were divided into stroke group and non-stroke group according to whether the prognosis occurred or not.Subsequently, the difference in clinical data was compared, the correlation of SMI and CEUS was analyzed, and multiple Cox regression and receiver operating characteristic curve were applied to investigate the value of SMI and CEUS in predicting cerebral arterial thrombosis in three years.RESULTS In this study, 43 patients were enrolled in the stroke group and 82 patients were enrolled in the non-stroke group. Cox regression revealed that SMI level(P =0.013) and enhancement intensity(P = 0.032) were the independent factors influencing ischemic stroke. There was a positive correlation between SMI level and enhancement intensity(r = 0.737, P = 0.000). The area under curve of SMI level predicting ischemic stroke was 0.878. The best diagnostic point was ≥ level Ⅱ, and its sensitivity and specificity was 86.05% and 79.27%. The area under curve of enhancement intensity predicting ischemic stroke was 0.890. The best diagnostic point was 9.92 db, and its sensitivity and specificity was 88.37% and89.02%. As the SMI level gradually increased, the incidence of ischemic stroke increased grad展开更多
At the end of 1982, Palmiter, Brinster et al. reported that mice of superb growth had been created through microinjection of a hybrid gene coding for rat growth hormone into the male pronuclei of mouse fertilized eggs...At the end of 1982, Palmiter, Brinster et al. reported that mice of superb growth had been created through microinjection of a hybrid gene coding for rat growth hormone into the male pronuclei of mouse fertilized eggs. This work ushered in a new approach to develop new breeds of domestic animals with a method of foreign gene trans-formation. We infer that fish, on a lower level of evolution in vertebrata,展开更多
AIM: To identify the hepatic vascular architecture of patients with hepatitis C virus (HCV) using superb microvascular imaging (SMI) and investigate the use of SMI in the evaluation of liver fibrosis.METHODS: SMI was ...AIM: To identify the hepatic vascular architecture of patients with hepatitis C virus (HCV) using superb microvascular imaging (SMI) and investigate the use of SMI in the evaluation of liver fibrosis.METHODS: SMI was performed in 100 HCV patients. SMI images were classified into five types according to the vascular pattern, and these patterns were compared with the fibrosis stage. Moreover, the images were analyzed to examine vascularity by integrating the number of SMI signals in the region of interest ROI [number of vascular trees (VT)]. The number of VT, fibrosis stage, serum parameters of liver function, and CD34 expression were investigated.RESULTS: There was a significant difference between SMI distribution pattern and fibrosis stage (P < 0.001). The mean VT values in each of the fibrosis stages were as follows: 26.69 ± 7.08 in F0, 27.72 ± 9.32 in F1, 36.74 ± 9.23 in F2, 37.36 ± 5.32 in F3, and 58.14 ± 14.08 in F4. The VT showed excellent diagnostic ability for F4 [area under the receiver operator characteristic (AUROC): 0.911]. The VT was significantly correlated with the CD34 labeling index (r = 0.617, P < 0.0001).CONCLUSION: SMI permitted the detailed delineation of the vascular architecture in chronic liver disease. SMI appears to be a reliable tool for noninvasively detecting significant fibrosis or cirrhosis in HCV patients.展开更多
BACKGROUND Madelung’s disease,also known as multiple symmetrical lipomatosis,is a rare,underrecognized disorder of fat metabolism that results in unusual accumulation of subcutaneous fat deposits around the neck,shou...BACKGROUND Madelung’s disease,also known as multiple symmetrical lipomatosis,is a rare,underrecognized disorder of fat metabolism that results in unusual accumulation of subcutaneous fat deposits around the neck,shoulders,upper arms,trunk,hips,and upper thighs.Our case demonstrates the importance of differential diagnosis and the value of a superb microvascular imaging technique for suspecting and confirming Madelung’s disease.Timely diagnosis and alcohol abstinence could prevent the progression of growing fatty masses and prevent surgery.CASE SUMMARY A 62-year-old male was admitted to the Rheumatology center complaining of symmetric subcutaneous tumors in the area of the parotid and submandibular salivary glands,small soft masses in the occiput and upper third of the forearm,rashes on calves.A high titer of rheumatoid factor and low concentrations of serum complements were detected.The high-end ultrasound and magnetic resonance imaging examinations of all affected areas of the soft tissues showed predominantly adipose tissue(lipomas)without suspicion of liposarcoma.The biopsy from the small salivary gland revealed no pathology.After evaluating the patient’s clinical presentation(symmetrical lipomatosis,cirrhosis,gynecomastia,anemia,hyperuricemia),Madelung’s disease,type I,along with the psoriatic rash and psoriatic arthritis and secondary liver cirrhosis were established.CONCLUSION Madelung’s disease consists of many co-occurring disorders imitating and overlapping with other conditions.Ultrasonography is the first choice for suspecting and confirming symmetrical lipomatosis.展开更多
BACKGROUND Septic arthritis of the manubriosternal joint is a diagnostic challenge due to its rarity and anatomical characteristic.Conventional ultrasound,plain radiographs,and computed tomography are not able to conf...BACKGROUND Septic arthritis of the manubriosternal joint is a diagnostic challenge due to its rarity and anatomical characteristic.Conventional ultrasound,plain radiographs,and computed tomography are not able to confirm or even suspect arthritis early.Superb microvascular imaging is a new advanced Doppler technique in evaluating low-flow microvascular patterns.The higher sensitivity for increased perisynovial vascularity helps to suspect septic arthritis and forms a methodical approach to using magnetic resonance imaging(MRI).CASE SUMMARY A 34-year-old immunocompetent woman presented with a fever and a dull ache in the chest radiating to the right arm.Traumatic injury and the most common respiratory and cardiac disorders were ruled out.Blood cultures came back positive for Staphylococcus aureus,and sepsis was confirmed.A small lump was noted on the chest during the first week of hospitalization.Superb microvascular imaging was performed and septic arthritis of the manubriosternal joint was detected.MRI confirmed the diagnosis and showed septic arthritis of the manubriosternal joint with several localized abscesses behind the sternum.The patient was treated for three weeks with intravenous antibiotics and the outcome was favorable:Inflammatory markers became normal,and the lump disappeared.Three months later,the patient was examined for a new episode of mild pain in the sternum and was diagnosed with persistent perichondritis by ultrasound in comparison with MRI.CONCLUSION Superb microvascular imaging is a useful tool for the early diagnosis of septic arthritis of the manubriosternal joint and following-up.展开更多
紫外成像技术对变电设备的电晕、闪络和电弧有较好的检测效果,通过检测放电部位辐射紫外线,能间接评估运行设备的绝缘状况并及时发现绝缘设备的缺陷。用Super B便携式紫外成像仪在不同的气象环境下对多座500 k V变电站进行了现场检测,...紫外成像技术对变电设备的电晕、闪络和电弧有较好的检测效果,通过检测放电部位辐射紫外线,能间接评估运行设备的绝缘状况并及时发现绝缘设备的缺陷。用Super B便携式紫外成像仪在不同的气象环境下对多座500 k V变电站进行了现场检测,发现了部分设备的电晕放电现象,验证了紫外成像检测技术的实用性。展开更多
Gongbi painting is a tra-ditional Chinese real-istic style of paintingcharacterized by fine brush-work and close attention todetail.It has a long history,asit flourished and dominatedChinese painting circles be-fore t...Gongbi painting is a tra-ditional Chinese real-istic style of paintingcharacterized by fine brush-work and close attention todetail.It has a long history,asit flourished and dominatedChinese painting circles be-fore the Yuan Dynasty(1271-1368)and was called“superb art.″Characteristics of the gong-bi style are seen in the totemsthat appeared in matriarchalsociety 40,000 years ago;indesigns of fish and insects oncolored pottery in the NewStone Age 5,000 years ago;in pictures depicting war andhunting scenes on bronzeware4,000 years ago;in silk paint-ings of the late Zhou Dynasty(11th century to 221 B.C.),展开更多
The rise of Daesh(ISIS) brings terrorism to a new era, compared with its military combat capability, funds-raising ability and inhuman terrorist acts, its deliberate and superb media propaganda strategy and offense ar...The rise of Daesh(ISIS) brings terrorism to a new era, compared with its military combat capability, funds-raising ability and inhuman terrorist acts, its deliberate and superb media propaganda strategy and offense are also astonishing. Daesh tries to use media propaganda to achieve multiple strategic objectives: building a strong brand for attraction, roping in the extreme elements or organizations to balance counterparts, and creating a terrorist psychological deterrent to peoples and the governments of all countries. For this, the international community has been on the alert, but the prevention and combat are far from enough. International media cooperation is weak, lack of relevant media ethics standards and rules, and media strategy of counter terrorism short of investment and other resources, which have seriously hampered development of the media war on terror. To achieve victory on both "online" and "offline" will be the only outlet to win the final victory of the international war on terror.展开更多
SCATTERED in the outskirtsof Xuzhou,Jiangsu Province,are Han tombs on a grandscale with stone reliefs,regarded byarchaeologists as rare treasures,thatdepict life 1,700 years ago and,atthe same time,display superb skil...SCATTERED in the outskirtsof Xuzhou,Jiangsu Province,are Han tombs on a grandscale with stone reliefs,regarded byarchaeologists as rare treasures,thatdepict life 1,700 years ago and,atthe same time,display superb skillsin painting and carvingAt the end of the third centuryB.C.Xuzhou was the home of Em-peror Liu Bang,founder of the HanDynasty.and also the home of展开更多
基金Supported by Shanghai Jiading District Health and Family Planning Commission Health Planning Commission Scientific Research Project,No.KYXM,2015-KY-02
文摘BACKGROUND Unstable carotid atherosclerotic plaques are prone to cause ischemic stroke.Contrast-enhanced ultrasound(CEUS) is the primary method of assessing plaque stability, but CEUS cannot be a method for screening for unstable plaque. The emergence of superb micro-vascular imaging(SMI) offers the possibility of clinically screening for unstable plaque AIM To investigate the value of SMI in predicting ischemic stroke in patients with carotid atherosclerotic plaques.METHODS Patients with carotid atherosclerotic plaques(luminal stenosis of 50%-70%) were enrolled into the present study. All patients received conservative medication.The patient's clinical baseline data, serological data, CEUS and SMI data were analyzed. All patients underwent a 3-year follow-up. The follow-up endpoint was the occurrence of ischemic stroke and patients were divided into stroke group and non-stroke group according to whether the prognosis occurred or not.Subsequently, the difference in clinical data was compared, the correlation of SMI and CEUS was analyzed, and multiple Cox regression and receiver operating characteristic curve were applied to investigate the value of SMI and CEUS in predicting cerebral arterial thrombosis in three years.RESULTS In this study, 43 patients were enrolled in the stroke group and 82 patients were enrolled in the non-stroke group. Cox regression revealed that SMI level(P =0.013) and enhancement intensity(P = 0.032) were the independent factors influencing ischemic stroke. There was a positive correlation between SMI level and enhancement intensity(r = 0.737, P = 0.000). The area under curve of SMI level predicting ischemic stroke was 0.878. The best diagnostic point was ≥ level Ⅱ, and its sensitivity and specificity was 86.05% and 79.27%. The area under curve of enhancement intensity predicting ischemic stroke was 0.890. The best diagnostic point was 9.92 db, and its sensitivity and specificity was 88.37% and89.02%. As the SMI level gradually increased, the incidence of ischemic stroke increased grad
基金Project supported by the Science Fund of Academia Sinica
文摘At the end of 1982, Palmiter, Brinster et al. reported that mice of superb growth had been created through microinjection of a hybrid gene coding for rat growth hormone into the male pronuclei of mouse fertilized eggs. This work ushered in a new approach to develop new breeds of domestic animals with a method of foreign gene trans-formation. We infer that fish, on a lower level of evolution in vertebrata,
文摘AIM: To identify the hepatic vascular architecture of patients with hepatitis C virus (HCV) using superb microvascular imaging (SMI) and investigate the use of SMI in the evaluation of liver fibrosis.METHODS: SMI was performed in 100 HCV patients. SMI images were classified into five types according to the vascular pattern, and these patterns were compared with the fibrosis stage. Moreover, the images were analyzed to examine vascularity by integrating the number of SMI signals in the region of interest ROI [number of vascular trees (VT)]. The number of VT, fibrosis stage, serum parameters of liver function, and CD34 expression were investigated.RESULTS: There was a significant difference between SMI distribution pattern and fibrosis stage (P < 0.001). The mean VT values in each of the fibrosis stages were as follows: 26.69 ± 7.08 in F0, 27.72 ± 9.32 in F1, 36.74 ± 9.23 in F2, 37.36 ± 5.32 in F3, and 58.14 ± 14.08 in F4. The VT showed excellent diagnostic ability for F4 [area under the receiver operator characteristic (AUROC): 0.911]. The VT was significantly correlated with the CD34 labeling index (r = 0.617, P < 0.0001).CONCLUSION: SMI permitted the detailed delineation of the vascular architecture in chronic liver disease. SMI appears to be a reliable tool for noninvasively detecting significant fibrosis or cirrhosis in HCV patients.
文摘BACKGROUND Madelung’s disease,also known as multiple symmetrical lipomatosis,is a rare,underrecognized disorder of fat metabolism that results in unusual accumulation of subcutaneous fat deposits around the neck,shoulders,upper arms,trunk,hips,and upper thighs.Our case demonstrates the importance of differential diagnosis and the value of a superb microvascular imaging technique for suspecting and confirming Madelung’s disease.Timely diagnosis and alcohol abstinence could prevent the progression of growing fatty masses and prevent surgery.CASE SUMMARY A 62-year-old male was admitted to the Rheumatology center complaining of symmetric subcutaneous tumors in the area of the parotid and submandibular salivary glands,small soft masses in the occiput and upper third of the forearm,rashes on calves.A high titer of rheumatoid factor and low concentrations of serum complements were detected.The high-end ultrasound and magnetic resonance imaging examinations of all affected areas of the soft tissues showed predominantly adipose tissue(lipomas)without suspicion of liposarcoma.The biopsy from the small salivary gland revealed no pathology.After evaluating the patient’s clinical presentation(symmetrical lipomatosis,cirrhosis,gynecomastia,anemia,hyperuricemia),Madelung’s disease,type I,along with the psoriatic rash and psoriatic arthritis and secondary liver cirrhosis were established.CONCLUSION Madelung’s disease consists of many co-occurring disorders imitating and overlapping with other conditions.Ultrasonography is the first choice for suspecting and confirming symmetrical lipomatosis.
文摘BACKGROUND Septic arthritis of the manubriosternal joint is a diagnostic challenge due to its rarity and anatomical characteristic.Conventional ultrasound,plain radiographs,and computed tomography are not able to confirm or even suspect arthritis early.Superb microvascular imaging is a new advanced Doppler technique in evaluating low-flow microvascular patterns.The higher sensitivity for increased perisynovial vascularity helps to suspect septic arthritis and forms a methodical approach to using magnetic resonance imaging(MRI).CASE SUMMARY A 34-year-old immunocompetent woman presented with a fever and a dull ache in the chest radiating to the right arm.Traumatic injury and the most common respiratory and cardiac disorders were ruled out.Blood cultures came back positive for Staphylococcus aureus,and sepsis was confirmed.A small lump was noted on the chest during the first week of hospitalization.Superb microvascular imaging was performed and septic arthritis of the manubriosternal joint was detected.MRI confirmed the diagnosis and showed septic arthritis of the manubriosternal joint with several localized abscesses behind the sternum.The patient was treated for three weeks with intravenous antibiotics and the outcome was favorable:Inflammatory markers became normal,and the lump disappeared.Three months later,the patient was examined for a new episode of mild pain in the sternum and was diagnosed with persistent perichondritis by ultrasound in comparison with MRI.CONCLUSION Superb microvascular imaging is a useful tool for the early diagnosis of septic arthritis of the manubriosternal joint and following-up.
文摘Gongbi painting is a tra-ditional Chinese real-istic style of paintingcharacterized by fine brush-work and close attention todetail.It has a long history,asit flourished and dominatedChinese painting circles be-fore the Yuan Dynasty(1271-1368)and was called“superb art.″Characteristics of the gong-bi style are seen in the totemsthat appeared in matriarchalsociety 40,000 years ago;indesigns of fish and insects oncolored pottery in the NewStone Age 5,000 years ago;in pictures depicting war andhunting scenes on bronzeware4,000 years ago;in silk paint-ings of the late Zhou Dynasty(11th century to 221 B.C.),
文摘The rise of Daesh(ISIS) brings terrorism to a new era, compared with its military combat capability, funds-raising ability and inhuman terrorist acts, its deliberate and superb media propaganda strategy and offense are also astonishing. Daesh tries to use media propaganda to achieve multiple strategic objectives: building a strong brand for attraction, roping in the extreme elements or organizations to balance counterparts, and creating a terrorist psychological deterrent to peoples and the governments of all countries. For this, the international community has been on the alert, but the prevention and combat are far from enough. International media cooperation is weak, lack of relevant media ethics standards and rules, and media strategy of counter terrorism short of investment and other resources, which have seriously hampered development of the media war on terror. To achieve victory on both "online" and "offline" will be the only outlet to win the final victory of the international war on terror.
文摘SCATTERED in the outskirtsof Xuzhou,Jiangsu Province,are Han tombs on a grandscale with stone reliefs,regarded byarchaeologists as rare treasures,thatdepict life 1,700 years ago and,atthe same time,display superb skillsin painting and carvingAt the end of the third centuryB.C.Xuzhou was the home of Em-peror Liu Bang,founder of the HanDynasty.and also the home of
