1) Background: Osteoarthritis (OA) is defined as a degenerative joint disease that mainly affects the bone. This study aims to evaluate the effect of low-intensity continuous ultrasound (LICUS) treatment on the knee o...1) Background: Osteoarthritis (OA) is defined as a degenerative joint disease that mainly affects the bone. This study aims to evaluate the effect of low-intensity continuous ultrasound (LICUS) treatment on the knee of osteoarthritis patients through home-based intervention using the LICUS medical device. 2) Methods: The clinical trials were designed in a single-arm, open-label, and intervention study. Thirty-five participants, including those who dropped out (12%), were screened and enrolled. The patients received LICUS (1.1 MHz, 1.5 W/cm2, collimated beams) on the knee by the instructions of the investigator at home (5 min/session, 3 times/day, for four-weeks). Outcome measures were assessed using the Visual Analog Scale (VAS) as a primary endpoint and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) as a secondary endpoint to evaluate pain relief and functional recovery of the knee between pre-treatment (baseline) and post-treatment (four-weeks). 3) Results: Knee pain scores measured using the VAS and WOMAC indices were significantly reduced after a four-week treatment with LICUS compared to baseline. Knee stiffness and functional capacity were significantly reduced after the LICUS application. In addition, there were no reports of adverse effects during the study period. 4) Conclusion: Long-term and home-based application of LICUS can be recommended as an alternative option for the treatment of OA patients, as evidenced by the effect of pain relief and knee function recovery.展开更多
Stimulated Brillouin scattering-induced phase noise is harmful to interferometric fiber sensing systems. The localized fluctuating model is used to study the intensity noise caused by the stimulated Brillouin scatteri...Stimulated Brillouin scattering-induced phase noise is harmful to interferometric fiber sensing systems. The localized fluctuating model is used to study the intensity noise caused by the stimulated Brillouin scattering in a single-mode fiber. The phase noise structure is analyzed for an interferometric fiber sensing system, and an unbalanced Michelson interferometer with an optical path difference of 1 m, as well as the phase-generated carrier technique, is used to measure the phase noise. It is found that the phase noise is small when the input power is below the stimulated Brillouin scattering threshold, increases dramatically at first and then gradually becomes flat when the input power is above the threshold, which is similar to the variation in relative intensity noise. It can be inferred that the increase in phase noise is mainly due to the broadening of the laser linewidth caused by stimulated Brillouin scattering, which is verified through linewidth measurements in the absence and presence of the stimulated Brillouin scattering.展开更多
Laser pulses of 200 ps with extremely high intensities and high energies are sufficient to satisfy the demand of shock ignition,which is an alternative path to ignition in inertial confinement fusion(ICF).This paper r...Laser pulses of 200 ps with extremely high intensities and high energies are sufficient to satisfy the demand of shock ignition,which is an alternative path to ignition in inertial confinement fusion(ICF).This paper reports a type of Brillouin scheme to obtain high-intensity 200-ps laser pulses,where the pulse durations are a challenge for conventional pulsed laser amplification systems.In the amplification process,excited Brillouin acoustic waves fulfill the nonlinear optical effect through which the high energy of a long pump pulse is entirely transferred to a 200-ps laser pulse.This method was introduced and achieved within the SG-Ⅲprototype system in China.Compared favorably with the intensity of 2 GW/cm^2 in existing ICF laser drivers,a 6.96-GW/cm^2 pulse with a width of 170 ps was obtained in our experiment.The practical scalability of the results to larger ICF laser drivers is discussed.展开更多
文摘1) Background: Osteoarthritis (OA) is defined as a degenerative joint disease that mainly affects the bone. This study aims to evaluate the effect of low-intensity continuous ultrasound (LICUS) treatment on the knee of osteoarthritis patients through home-based intervention using the LICUS medical device. 2) Methods: The clinical trials were designed in a single-arm, open-label, and intervention study. Thirty-five participants, including those who dropped out (12%), were screened and enrolled. The patients received LICUS (1.1 MHz, 1.5 W/cm2, collimated beams) on the knee by the instructions of the investigator at home (5 min/session, 3 times/day, for four-weeks). Outcome measures were assessed using the Visual Analog Scale (VAS) as a primary endpoint and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) as a secondary endpoint to evaluate pain relief and functional recovery of the knee between pre-treatment (baseline) and post-treatment (four-weeks). 3) Results: Knee pain scores measured using the VAS and WOMAC indices were significantly reduced after a four-week treatment with LICUS compared to baseline. Knee stiffness and functional capacity were significantly reduced after the LICUS application. In addition, there were no reports of adverse effects during the study period. 4) Conclusion: Long-term and home-based application of LICUS can be recommended as an alternative option for the treatment of OA patients, as evidenced by the effect of pain relief and knee function recovery.
基金Project supported by the National Natural Science Foundation of China (Grant No. 61177073)the Open Fund of Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes, Jinan University, China (Grant No. gdol201101)+1 种基金the Fund of Innovation of Graduate School of NUDT, China (Grant No. B110703)Hunan Provincial Innovation Foundation for Postgraduate,China (Grant No. CX2011B033)
文摘Stimulated Brillouin scattering-induced phase noise is harmful to interferometric fiber sensing systems. The localized fluctuating model is used to study the intensity noise caused by the stimulated Brillouin scattering in a single-mode fiber. The phase noise structure is analyzed for an interferometric fiber sensing system, and an unbalanced Michelson interferometer with an optical path difference of 1 m, as well as the phase-generated carrier technique, is used to measure the phase noise. It is found that the phase noise is small when the input power is below the stimulated Brillouin scattering threshold, increases dramatically at first and then gradually becomes flat when the input power is above the threshold, which is similar to the variation in relative intensity noise. It can be inferred that the increase in phase noise is mainly due to the broadening of the laser linewidth caused by stimulated Brillouin scattering, which is verified through linewidth measurements in the absence and presence of the stimulated Brillouin scattering.
基金supported in part by the National Natural Science Foundation of China (NSFC) (No. 61622501)the China Postdoctoral Science Foundation (No. BX20180085)
文摘Laser pulses of 200 ps with extremely high intensities and high energies are sufficient to satisfy the demand of shock ignition,which is an alternative path to ignition in inertial confinement fusion(ICF).This paper reports a type of Brillouin scheme to obtain high-intensity 200-ps laser pulses,where the pulse durations are a challenge for conventional pulsed laser amplification systems.In the amplification process,excited Brillouin acoustic waves fulfill the nonlinear optical effect through which the high energy of a long pump pulse is entirely transferred to a 200-ps laser pulse.This method was introduced and achieved within the SG-Ⅲprototype system in China.Compared favorably with the intensity of 2 GW/cm^2 in existing ICF laser drivers,a 6.96-GW/cm^2 pulse with a width of 170 ps was obtained in our experiment.The practical scalability of the results to larger ICF laser drivers is discussed.
