Four novel compounds containing two pyridazinone units attached to one benzene or pyridine ring, protected and deprotected 1,5-di[3（2H）-pyridazinon-6-yl]benzene and 2,6-di[3（2H）-pyridazinon-6-yl]pyridine were synt...Four novel compounds containing two pyridazinone units attached to one benzene or pyridine ring, protected and deprotected 1,5-di[3（2H）-pyridazinon-6-yl]benzene and 2,6-di[3（2H）-pyridazinon-6-yl]pyridine were synthesized in eight steps, which provided a useful method for the preparation of pyridazinone derivatives via the Stetter and cyclization reactions. Their structures were characterized by ^1H NMR, ^13C NMR, and HRMS.展开更多
Intermolecular Stetter reaction of aromatic aldehydes with（E）-（2-nitrovinyl）cyclohexane catalyzed by thiazolium A has been developed.The reaction rate and efficiency are profoundly impacted by the presence of thio...Intermolecular Stetter reaction of aromatic aldehydes with（E）-（2-nitrovinyl）cyclohexane catalyzed by thiazolium A has been developed.The reaction rate and efficiency are profoundly impacted by the presence of thiourea B.The reaction affords moderate to good yields of the Stetter product.Some factors influencing yield were discussed.展开更多
基金Support by the National Natural Science Foundation of China(No.20571063)
文摘Four novel compounds containing two pyridazinone units attached to one benzene or pyridine ring, protected and deprotected 1,5-di[3（2H）-pyridazinon-6-yl]benzene and 2,6-di[3（2H）-pyridazinon-6-yl]pyridine were synthesized in eight steps, which provided a useful method for the preparation of pyridazinone derivatives via the Stetter and cyclization reactions. Their structures were characterized by ^1H NMR, ^13C NMR, and HRMS.
基金supported by the Prospective Research Funds of Jiangsu Provincial Department of Science and Technology (No. BY2015049-02)the Open-end Funds of Jiangsu Key Laboratory of Marine Biotechnology, Huaihai Institute of Technology, (No. 2014HS005)the Funds of Technology Research of Lianyungang (No. CG1301)
文摘Intermolecular Stetter reaction of aromatic aldehydes with（E）-（2-nitrovinyl）cyclohexane catalyzed by thiazolium A has been developed.The reaction rate and efficiency are profoundly impacted by the presence of thiourea B.The reaction affords moderate to good yields of the Stetter product.Some factors influencing yield were discussed.
