The peritoneum is the most common site of recurrence of gastric cancer(GC).Early occult peritoneal metastasis is difficult to detect by imaging examination.Stratifying the risk of peritoneal metastasis in patients wit...The peritoneum is the most common site of recurrence of gastric cancer(GC).Early occult peritoneal metastasis is difficult to detect by imaging examination.Stratifying the risk of peritoneal metastasis in patients with different Lauren subtypes is of great clinical value.We performed a univariate Cox regression to identify those genes with prognostic value of overall survival(OS)and peritoneal-specified disease-free survival(psDFS)from the Gene Expression Omnibus database.The candidate genes were screened by the Subpopulation Treatment Effect Pattern Plot(STEPP)method.Propensity score matching(PSM)analysis was used to reduce the interference of confounders on the results.Based on the optimal cut-off values determined by the STEPP method,we found overexpression of three genes(HAND2-AS1,PRKAA2,and VLDLR)was correlated with shorter 1-year psDFS among patients with diffuse-type than that of patients with intestinal-type GC,and it is highly significant.Gene Set Enrichment Analysis(GSEA)potentially suggested that the three genes promote the early occurrence of peritoneal metastasis in patients with diffuse-type GC through glucose metabolism-related pathways.These three genes may be potential biomarkers.They can be used to assess the risk of peritoneal metastases to guide treatment decisions and follow-up strategies.展开更多
Soil salinization and degradation of the vegetation cover is a problem of international topicality, that arises particularly in arid and semi arid regions, of where part of our study sites, and for know their floristi...Soil salinization and degradation of the vegetation cover is a problem of international topicality, that arises particularly in arid and semi arid regions, of where part of our study sites, and for know their floristic diversity, we attempted achieve a floristic inventory in stations undergoing a dry climate and intense anthropic action particularly in the north-west of Algeria. A protected station was considered as controls. In the Mediterranean region, the reading surface varies from 100 m^2 to 300 m^2 in forest, and 50 m^2 to 100 m^2 in matorrals and a few square meters in lawns [1], and for our case, we used the readings method by transect with the plots （100 m^2）. The interpretation of the vegetation has been done using a multidimensional treatment AFC. The results prove that the flora of study sites shows a floristic richness, although human action and rigor of the Mediterranean climate seem to have a negative effect on vegetation by the proliferation of xeric species and halophytes and sometimes toxic. The results show that the flora of the study sites shows a rich flora formed by the combination of annual and perennial communities where Therophytes dominate other life forms and in terms biogeographic Mediterranean species take the first place of all identified species, while endemic species are poorly re-presented. The Protected Station of Dam Hammam Boughrara presents no significant difference compared to other stations which are not put in defending.展开更多
基金This research was approved by National Natural Science Foundation of China(No.81972331)National Science and Technology Major Project of the Ministry of Science and Technology of China(No.2017ZX09304025).
文摘The peritoneum is the most common site of recurrence of gastric cancer(GC).Early occult peritoneal metastasis is difficult to detect by imaging examination.Stratifying the risk of peritoneal metastasis in patients with different Lauren subtypes is of great clinical value.We performed a univariate Cox regression to identify those genes with prognostic value of overall survival(OS)and peritoneal-specified disease-free survival(psDFS)from the Gene Expression Omnibus database.The candidate genes were screened by the Subpopulation Treatment Effect Pattern Plot(STEPP)method.Propensity score matching(PSM)analysis was used to reduce the interference of confounders on the results.Based on the optimal cut-off values determined by the STEPP method,we found overexpression of three genes(HAND2-AS1,PRKAA2,and VLDLR)was correlated with shorter 1-year psDFS among patients with diffuse-type than that of patients with intestinal-type GC,and it is highly significant.Gene Set Enrichment Analysis(GSEA)potentially suggested that the three genes promote the early occurrence of peritoneal metastasis in patients with diffuse-type GC through glucose metabolism-related pathways.These three genes may be potential biomarkers.They can be used to assess the risk of peritoneal metastases to guide treatment decisions and follow-up strategies.
文摘Soil salinization and degradation of the vegetation cover is a problem of international topicality, that arises particularly in arid and semi arid regions, of where part of our study sites, and for know their floristic diversity, we attempted achieve a floristic inventory in stations undergoing a dry climate and intense anthropic action particularly in the north-west of Algeria. A protected station was considered as controls. In the Mediterranean region, the reading surface varies from 100 m^2 to 300 m^2 in forest, and 50 m^2 to 100 m^2 in matorrals and a few square meters in lawns [1], and for our case, we used the readings method by transect with the plots （100 m^2）. The interpretation of the vegetation has been done using a multidimensional treatment AFC. The results prove that the flora of study sites shows a floristic richness, although human action and rigor of the Mediterranean climate seem to have a negative effect on vegetation by the proliferation of xeric species and halophytes and sometimes toxic. The results show that the flora of the study sites shows a rich flora formed by the combination of annual and perennial communities where Therophytes dominate other life forms and in terms biogeographic Mediterranean species take the first place of all identified species, while endemic species are poorly re-presented. The Protected Station of Dam Hammam Boughrara presents no significant difference compared to other stations which are not put in defending.
