目的观察太极拳锻炼对慢性失眠障碍(CID)患者睡眠质量的影响,并探讨其作用机制。方法收集2015年1月至2017年12月在睡眠障碍门诊就诊的CID患者31例。太极拳锻炼24周前后,采用匹兹堡睡眠质量指数(PSQI)评估患者睡眠质量;采用蛋白芯片检测...目的观察太极拳锻炼对慢性失眠障碍(CID)患者睡眠质量的影响,并探讨其作用机制。方法收集2015年1月至2017年12月在睡眠障碍门诊就诊的CID患者31例。太极拳锻炼24周前后,采用匹兹堡睡眠质量指数(PSQI)评估患者睡眠质量;采用蛋白芯片检测患者血清肿瘤坏死因子(TNF)-α、TNF-β和可溶性肿瘤坏死因子受体(sTNF-R)1、sTNF-R2水平,并分析锻炼后PSQI评分与之相关性。结果太极拳锻炼24周后,CID患者PSQI各因子(睡眠质量、入睡时间、睡眠时间、睡眠效率、睡眠障碍、日间功能)评分及PSQI总分均较锻炼前降低(t> 4.080, P <0.05);血清TNF-α、TNF-β水平明显下降(t>13.580, P <0.01),血清sTNF-R1、sTNF-R2水平显著上升(t> 160.189, P <0.001);血清TNF-α、TNF-β水平与PSQI评分呈显著正相关(r> 0.638, P <0.001),而血清sTNF-R1、sTNF-R2水平与PSQI评分呈显著负相关(r <-0.532, P <0.001)。结论 CID患者太极拳锻炼后睡眠质量改善,可能与降低血清TNF-α、TNF-β水平,上调血清sTNF-R1、sTNFR2水平有关。展开更多
The course and severity of periodontitis can be significantly affected by bacterial virulence as well as host immunity dysfunction. Periodontal tissue destruction has been proved to result from cascade of cytokines sy...The course and severity of periodontitis can be significantly affected by bacterial virulence as well as host immunity dysfunction. Periodontal tissue destruction has been proved to result from cascade of cytokines synthesized by reactive cells upon stimulation by pathogenic bacteria and lipopolysaccharides within their cell membranes. The clinical use of genetically programmed cells, producing substances blocking IL-1, based on recombinant IL-1 antagonist, as well as cytokines activating fibroblasts and osteoblasts to regenerate the destroyed periodontal tissue could prove alternative to the conventional treatment. Another cytokine of interest in respect to periodontitis ethiopathogenesis is soluble tumor necrosis factor receptor I (sTNF RI). Observation of soluble TNF receptors as physiologic inhibitors of TNF led to its administration in therapeutic process as well as in therapy selected cases of aggressive periodontitis.展开更多
文摘目的观察太极拳锻炼对慢性失眠障碍(CID)患者睡眠质量的影响,并探讨其作用机制。方法收集2015年1月至2017年12月在睡眠障碍门诊就诊的CID患者31例。太极拳锻炼24周前后,采用匹兹堡睡眠质量指数(PSQI)评估患者睡眠质量;采用蛋白芯片检测患者血清肿瘤坏死因子(TNF)-α、TNF-β和可溶性肿瘤坏死因子受体(sTNF-R)1、sTNF-R2水平,并分析锻炼后PSQI评分与之相关性。结果太极拳锻炼24周后,CID患者PSQI各因子(睡眠质量、入睡时间、睡眠时间、睡眠效率、睡眠障碍、日间功能)评分及PSQI总分均较锻炼前降低(t> 4.080, P <0.05);血清TNF-α、TNF-β水平明显下降(t>13.580, P <0.01),血清sTNF-R1、sTNF-R2水平显著上升(t> 160.189, P <0.001);血清TNF-α、TNF-β水平与PSQI评分呈显著正相关(r> 0.638, P <0.001),而血清sTNF-R1、sTNF-R2水平与PSQI评分呈显著负相关(r <-0.532, P <0.001)。结论 CID患者太极拳锻炼后睡眠质量改善,可能与降低血清TNF-α、TNF-β水平,上调血清sTNF-R1、sTNFR2水平有关。
文摘The course and severity of periodontitis can be significantly affected by bacterial virulence as well as host immunity dysfunction. Periodontal tissue destruction has been proved to result from cascade of cytokines synthesized by reactive cells upon stimulation by pathogenic bacteria and lipopolysaccharides within their cell membranes. The clinical use of genetically programmed cells, producing substances blocking IL-1, based on recombinant IL-1 antagonist, as well as cytokines activating fibroblasts and osteoblasts to regenerate the destroyed periodontal tissue could prove alternative to the conventional treatment. Another cytokine of interest in respect to periodontitis ethiopathogenesis is soluble tumor necrosis factor receptor I (sTNF RI). Observation of soluble TNF receptors as physiologic inhibitors of TNF led to its administration in therapeutic process as well as in therapy selected cases of aggressive periodontitis.
