核苷酸替代和indels(插入、缺失统称)发生是进化的重要动力。以茄科植物为研究对象,探讨茄属中番茄和马铃薯、烟草属中绒毛状烟草和普通烟草分化时叶绿体基因组indels和核苷酸替代的发生方式,以及这两种突变对基因组造成的影响。结果显...核苷酸替代和indels(插入、缺失统称)发生是进化的重要动力。以茄科植物为研究对象,探讨茄属中番茄和马铃薯、烟草属中绒毛状烟草和普通烟草分化时叶绿体基因组indels和核苷酸替代的发生方式,以及这两种突变对基因组造成的影响。结果显示:indels和核苷酸替代的发生都不是随意的。indels发生在A+T丰富的区域,1 bp indels占据总数的30%以上,大部分indels都为低于10bp的较短片段。核苷酸替代表现出Ts(转换)/Tv(颠换)偏差,但T→G,A→C颠换频率却明显增加。Ts/Tv比值出现种属特异性,番茄和马铃薯比较时替代的Ts/Tv比值低于绒毛状烟草和普通烟草比较时Ts/Tv比值。不同物种替代的(A+T)/(G+C)比值有一定差异,从而影响基因组的(G+C)%,此比值的差异与形成物种的生长习性有一定的关系。展开更多
Two new sesquiterpenoids,attributable to eudesmane-type（1 and 2,named solajiangxins F and G）,were isolated from the whole plant of Solanum lyratum.Their structures were elucidated on the basis of integrated spectros...Two new sesquiterpenoids,attributable to eudesmane-type（1 and 2,named solajiangxins F and G）,were isolated from the whole plant of Solanum lyratum.Their structures were elucidated on the basis of integrated spectroscopic techniques.In vitro,compounds 1 and 2 were found to show signifcant cytotoxic activity against selected cancer cells,including P-388,HONE-1 and HT-29.展开更多
文摘核苷酸替代和indels(插入、缺失统称)发生是进化的重要动力。以茄科植物为研究对象,探讨茄属中番茄和马铃薯、烟草属中绒毛状烟草和普通烟草分化时叶绿体基因组indels和核苷酸替代的发生方式,以及这两种突变对基因组造成的影响。结果显示:indels和核苷酸替代的发生都不是随意的。indels发生在A+T丰富的区域,1 bp indels占据总数的30%以上,大部分indels都为低于10bp的较短片段。核苷酸替代表现出Ts(转换)/Tv(颠换)偏差,但T→G,A→C颠换频率却明显增加。Ts/Tv比值出现种属特异性,番茄和马铃薯比较时替代的Ts/Tv比值低于绒毛状烟草和普通烟草比较时Ts/Tv比值。不同物种替代的(A+T)/(G+C)比值有一定差异,从而影响基因组的(G+C)%,此比值的差异与形成物种的生长习性有一定的关系。
基金financially supported by the Natural Science Foundation of Shandong Province (No. ZR2009CZ004)
文摘Two new sesquiterpenoids,attributable to eudesmane-type（1 and 2,named solajiangxins F and G）,were isolated from the whole plant of Solanum lyratum.Their structures were elucidated on the basis of integrated spectroscopic techniques.In vitro,compounds 1 and 2 were found to show signifcant cytotoxic activity against selected cancer cells,including P-388,HONE-1 and HT-29.
