This paper proposed a reliability design model for composite materials under the mixture of random and interval variables. Together with the inverse reliability analysis technique, the sequential single-loop optimizat...This paper proposed a reliability design model for composite materials under the mixture of random and interval variables. Together with the inverse reliability analysis technique, the sequential single-loop optimization method is applied to the reliability-based design of composites. In the sequential single-loop optimization, the optimization and the reliability analysis are decoupled to improve the computational efficiency. As shown in examples, the minimum weight problems under the constraint of structural reliability are solved for laminated composites. The Particle Swarm Optimization （PSO） algorithm is utilized to search for the optimal solutions. The design results indicate that, under the mixture of random and interval variables, the method that combines the sequential single-loop optimization and the PSO algorithm can deal effectively with the reliability-based design of composites.展开更多
In renewable power generation systems,ensuring the synchronization of the inverter and the power grid is crucial for the stable operation of grid-connected inverters.Nowadays,the phase-locked loop(PLL)technology has b...In renewable power generation systems,ensuring the synchronization of the inverter and the power grid is crucial for the stable operation of grid-connected inverters.Nowadays,the phase-locked loop(PLL)technology has become a widely used grid synchronization method because of its simple implementation and robustness under various grid conditions.Even though a lot of PLLs have been proposed,an overview and comparative analysis of multiple PLLs can be helpful for practical applications.In addition,the weak grid condition is a great challenge for the system.Therefore,this study first presents an overview of the existing PLLs together with their general structures and basic working principles.Depending on the implementation of the phase detector,the PLL can be divided into three categories:power-based PLL(pPLL),orthogonal-signalgenerator-based PLL(OSG-PLL)and adaptive-filter-based PLL(AF-PLL).Then,from the above classification,seven typical single-phase PLLs are selected for further study.Finally,some test results are given,and a comprehensive evaluation of the selected PLLs under different grid conditions is conducted.展开更多
Peptide nucleic acids (PNAs) are synthetic oligonucleotides with chemically modified backbones. PNAs can bind to both DNA and RNA targets in a sequence-specific manner to form PNA/DNA and PNA/RNA duplex structures. Wh...Peptide nucleic acids (PNAs) are synthetic oligonucleotides with chemically modified backbones. PNAs can bind to both DNA and RNA targets in a sequence-specific manner to form PNA/DNA and PNA/RNA duplex structures. When bound to double-stranded DNA (dsDNA) targets, the PNA molecule replaces one DNA strand in the duplex by strand invasion to form a PNA/DNA/PNA [or (PNA)2/DNA] triplex structure and the displaced DNA strand exists as a singlestranded D-loop. PNA has been used in many studies as research tools for gene regulation and gene targeting. The Dloops generated from the PNA binding have also been demonstrated for its potential in initiating transcription and inducing gene expression. PNA provides a powerful tool to study the mechanism of transcription and an innovative strategy to regulate target gene expression. An understanding of the PNA-mediated gene regulation will have important clinical implications in treatment of many human diseases including genetic, cancerous, and age-related diseases.展开更多
基金the National Natural Science Foundation of China(No.10772070)Ph.D Programs Foundation of Ministry of Education of China(No.20070487064).
文摘This paper proposed a reliability design model for composite materials under the mixture of random and interval variables. Together with the inverse reliability analysis technique, the sequential single-loop optimization method is applied to the reliability-based design of composites. In the sequential single-loop optimization, the optimization and the reliability analysis are decoupled to improve the computational efficiency. As shown in examples, the minimum weight problems under the constraint of structural reliability are solved for laminated composites. The Particle Swarm Optimization （PSO） algorithm is utilized to search for the optimal solutions. The design results indicate that, under the mixture of random and interval variables, the method that combines the sequential single-loop optimization and the PSO algorithm can deal effectively with the reliability-based design of composites.
基金This work is supported in part by the National Natural Science Foundation of China(No.51807089,51877104)in part by the Natural Science Foundation of Jiangsu Province(No.BK20180432).
文摘In renewable power generation systems,ensuring the synchronization of the inverter and the power grid is crucial for the stable operation of grid-connected inverters.Nowadays,the phase-locked loop(PLL)technology has become a widely used grid synchronization method because of its simple implementation and robustness under various grid conditions.Even though a lot of PLLs have been proposed,an overview and comparative analysis of multiple PLLs can be helpful for practical applications.In addition,the weak grid condition is a great challenge for the system.Therefore,this study first presents an overview of the existing PLLs together with their general structures and basic working principles.Depending on the implementation of the phase detector,the PLL can be divided into three categories:power-based PLL(pPLL),orthogonal-signalgenerator-based PLL(OSG-PLL)and adaptive-filter-based PLL(AF-PLL).Then,from the above classification,seven typical single-phase PLLs are selected for further study.Finally,some test results are given,and a comprehensive evaluation of the selected PLLs under different grid conditions is conducted.
文摘Peptide nucleic acids (PNAs) are synthetic oligonucleotides with chemically modified backbones. PNAs can bind to both DNA and RNA targets in a sequence-specific manner to form PNA/DNA and PNA/RNA duplex structures. When bound to double-stranded DNA (dsDNA) targets, the PNA molecule replaces one DNA strand in the duplex by strand invasion to form a PNA/DNA/PNA [or (PNA)2/DNA] triplex structure and the displaced DNA strand exists as a singlestranded D-loop. PNA has been used in many studies as research tools for gene regulation and gene targeting. The Dloops generated from the PNA binding have also been demonstrated for its potential in initiating transcription and inducing gene expression. PNA provides a powerful tool to study the mechanism of transcription and an innovative strategy to regulate target gene expression. An understanding of the PNA-mediated gene regulation will have important clinical implications in treatment of many human diseases including genetic, cancerous, and age-related diseases.
