OBJECTIVE:To investigate the correlation between changes in brain activity associated with working memory and assessment scales of memory scores in amnestic mild cognitive impairment(aMCI)before and after moxibustion ...OBJECTIVE:To investigate the correlation between changes in brain activity associated with working memory and assessment scales of memory scores in amnestic mild cognitive impairment(aMCI)before and after moxibustion therapy.METHODS:aMCI patients were randomized into the moxibustion treatment(MT)group and the placebo moxibustion(PM)group.Each group received either moxibustion therapy or a placebo moxibustion for eight weeks.Neuropsychological performance and functional brain responses to a working memory task were assessed at baseline and at the end of treatment.Memory function was evaluated individually by the Rivermead behavioral memory test(RBMT),and working memory was assessed by the N-back task.RESULTS:Compared with the PM group,RBMT score changes were significant(P<0.05).In the MT group,the accuracy of the N-back texts increased compared with those before the intervention.After moxibustion intervention,the right insula,postcentral gyrus,precentral gyrus,superior temporal gyrus,thalamus,lingual gyrus,calcarine sulcus,posterior cingulate gyrus,middle frontal gyrus and anterior frontal gyrus were significantly activated(P=0.01,Cluster-level Family-Wise Error=0.05).Pearson correlation analysis showed that the insula,lingual gyrus and posterior cingulate gyrus were associated with changes in N-back score.Spearman correlation analysis showed that the postcentral gyrus,superior temporal gyrus,thalamus,lingual gyrus,and posterior cingulate gyrus were correlated with RBMT score changes.CONCLUSION:Moxibustion treatment improved memory in aMCI patients and was associated with the activation of the brain region of the insula,lingual gyrus,posterior cingulate gyrus,postcentral gyrus,superior temporal gyrus,and thalamus,which may be an important mechanism by which moxibustion improves the memory function.展开更多
Wet-cupping therapy(WCT)is one of the oldest known medical techniques,used as a traditional and complementary therapy with a wide application all around the world for general health.Research on the effects of WCT on s...Wet-cupping therapy(WCT)is one of the oldest known medical techniques,used as a traditional and complementary therapy with a wide application all around the world for general health.Research on the effects of WCT on sports performance are sparse and inconsistent.Thus,we aimed to explore the effects of WCT on repeated sprint ability,wellness,and exertion in young active males.Forty-nine active adult males(age:[28±5]years;body height[177±8]cm;body mass:[79±7]kg;body mass index:[25.4±1.8]kg/m^(2))were selected for the study.The participants performed a running-based sprint test on two separate occasions(Control and Post-WCT).WCT was performed 24 h before the testing session.They completed the Hooper questionnaire to assess their well-being(i.e.,sleep,stress,fatigue,and soreness)before each session.The rating of perceived exertion(RPE)was collected after each testing session.A higher maximum power(p<0.05,effect size[ES]=0.6),mean power(p<0.01,ES=0.5)and minimum power(p<0.01,ES=0.6)were recorded post-WCT as compared to Control session along with a better perceived sleep(p<0.01,ES=0.85).Perceived stress(p<0.01,ES=0.6)and RPE(p<0.001;ES=1.1)were lower during the post-WCT compared to the Control session.The present findings demonstrated that WCT moderately enhanced repeated sprint ability and had positive effects on perceived sleep,stress,and exertion.WCT may be an effective ergogenic aid to improve repeated sprint ability and general wellbeing in young adult males.Future large-scale multicentric clinical studies are paramount to confirm the results of our study.展开更多
基金the National Natural Science Foundation of China:to Study the Mechanism of Acupuncture Intervention for Amnestic Mild Cognitive Impairment Based on Episodic Memory Related Large-Scale Network(No.81973922)the Shenzhen Science and Technology Plan:to Explore the Effect of Tiaoshen Yizhi Acupuncture on Episodic Memory Effect Network in Patients with Amnestic Mild Cognitive Impairment Based on fMRI and EEG(No.JCYJ20190809151013581)+3 种基金Mechanism of Acupuncture Intervention for Amnestic Mild Cognitive Impairment Combined with Insomnia Based on Large-Scale Network(No.JCYJ20210324110809025)to Explore the Effect Mechanism of Baduanjin Training on Cognitive Impairment after Stroke Based on Attention Lateralization(No.JCYJ20220530142806014)Guangdong Basic and Applied Basic Research Foundation:to Explore the Mechanism of Baduanjin in Reducing the Risk of Falls in the Elderly with MCI Based on Vestibular Network Functional Connectivity(No.2021A1515110764)Shenzhen Baoan District Science and Technology Program:Effects of Repetitive Magnetic Stimulation on Brain Electrical Activity and Functional Network in Patients with Type 2 Diabetes Mellitus and Mild Cognitive Impairment(No.20210507221914001)。
文摘OBJECTIVE:To investigate the correlation between changes in brain activity associated with working memory and assessment scales of memory scores in amnestic mild cognitive impairment(aMCI)before and after moxibustion therapy.METHODS:aMCI patients were randomized into the moxibustion treatment(MT)group and the placebo moxibustion(PM)group.Each group received either moxibustion therapy or a placebo moxibustion for eight weeks.Neuropsychological performance and functional brain responses to a working memory task were assessed at baseline and at the end of treatment.Memory function was evaluated individually by the Rivermead behavioral memory test(RBMT),and working memory was assessed by the N-back task.RESULTS:Compared with the PM group,RBMT score changes were significant(P<0.05).In the MT group,the accuracy of the N-back texts increased compared with those before the intervention.After moxibustion intervention,the right insula,postcentral gyrus,precentral gyrus,superior temporal gyrus,thalamus,lingual gyrus,calcarine sulcus,posterior cingulate gyrus,middle frontal gyrus and anterior frontal gyrus were significantly activated(P=0.01,Cluster-level Family-Wise Error=0.05).Pearson correlation analysis showed that the insula,lingual gyrus and posterior cingulate gyrus were associated with changes in N-back score.Spearman correlation analysis showed that the postcentral gyrus,superior temporal gyrus,thalamus,lingual gyrus,and posterior cingulate gyrus were correlated with RBMT score changes.CONCLUSION:Moxibustion treatment improved memory in aMCI patients and was associated with the activation of the brain region of the insula,lingual gyrus,posterior cingulate gyrus,postcentral gyrus,superior temporal gyrus,and thalamus,which may be an important mechanism by which moxibustion improves the memory function.
文摘Wet-cupping therapy(WCT)is one of the oldest known medical techniques,used as a traditional and complementary therapy with a wide application all around the world for general health.Research on the effects of WCT on sports performance are sparse and inconsistent.Thus,we aimed to explore the effects of WCT on repeated sprint ability,wellness,and exertion in young active males.Forty-nine active adult males(age:[28±5]years;body height[177±8]cm;body mass:[79±7]kg;body mass index:[25.4±1.8]kg/m^(2))were selected for the study.The participants performed a running-based sprint test on two separate occasions(Control and Post-WCT).WCT was performed 24 h before the testing session.They completed the Hooper questionnaire to assess their well-being(i.e.,sleep,stress,fatigue,and soreness)before each session.The rating of perceived exertion(RPE)was collected after each testing session.A higher maximum power(p<0.05,effect size[ES]=0.6),mean power(p<0.01,ES=0.5)and minimum power(p<0.01,ES=0.6)were recorded post-WCT as compared to Control session along with a better perceived sleep(p<0.01,ES=0.85).Perceived stress(p<0.01,ES=0.6)and RPE(p<0.001;ES=1.1)were lower during the post-WCT compared to the Control session.The present findings demonstrated that WCT moderately enhanced repeated sprint ability and had positive effects on perceived sleep,stress,and exertion.WCT may be an effective ergogenic aid to improve repeated sprint ability and general wellbeing in young adult males.Future large-scale multicentric clinical studies are paramount to confirm the results of our study.
