OBJECTIVE: To investigate the dynamic changes and relationship of inducible nitric oxide synthase (iNOS) and apoptosis in endotoxin shock rats, as well as the effects of Sini injection. METHODS: In total, 102 Sprague-...OBJECTIVE: To investigate the dynamic changes and relationship of inducible nitric oxide synthase (iNOS) and apoptosis in endotoxin shock rats, as well as the effects of Sini injection. METHODS: In total, 102 Sprague-Dawley (SD) rats were randomly divided into a normal group (n=6, NG), sham operation group (n=24, OG), model group (n=24, MG), dexamethasone group (n=24, DG), and Sini group (n=24, SG). The endotoxin shock model was induced by an intravenous injection of lipopolysaccharide (LPS) (8 mg/kg). Rats in the OG, MG, DG, and SG groups were further divided into 4 groups: 1, 2, 3 and 6 h after shock groups (n=6 per group). iNOS expression was detected by immunohistochemistry. Terminal Deoxynucleotidyl Transferase Mediated Deoxyuridine Triphosphate-biotin Nick End Labeling was employed to measure apoptosis. RESULTS: No iNOS expression was found in the OG group. Compared with the OG group, iNOS expres-sion in the MG group was markedly elevated, reached a peak at 1 h (P<0.01), decreased at 2 and 3 h, and rebounded at 6 h. Compared with the MG group, iNOS expression decreased significantly in both the DG (P<0.05) and SG (P<0.01) groups at 6 h. Thenumberofapoptoticcellsin the MG group was markedly increased than that in the NG and OG (P<0.01) groups, and reached a peak at 6 h. The number of apoptotic cells in the DG group at 1 and 2 h (P<0.01) and SG group at 2, 3 and 6 h (P<0.01) decreased when compared with the MG group. CONCLUSION: Sini injection can significantly inhibit NO generation, which decreases apoptosis and subsequently protects the brain from endotoxic shock.展开更多
Objectives To assess the prognostic value of B-type natriuretic peptide （BNP） in severe AMI patients treated with intra-aortic ballon counterpulsation（IABP）. Methods A total of 42 AMI patients with cardiogenic sho...Objectives To assess the prognostic value of B-type natriuretic peptide （BNP） in severe AMI patients treated with intra-aortic ballon counterpulsation（IABP）. Methods A total of 42 AMI patients with cardiogenic shock were retrospectively studied. BNP plasma level was recorded in the 24th hour and 4th day after myocardial infarction. The different mortality were compared among patients with different BNP levels. Results With aggressive treatment, 20 patients survived short term hospitalization. Plasma concentration of BNP in dying patients is much higher than in survivals（1369 ± 353 vs 651 ± 302 pg/ml. P〈 0.01）.Patients with BNP higher than 1474 pg/mL had a mortality of 92.9 %. Conclusions Elevated BNP level in AMI patients with cardiogenic shock treated with IABP is highly associated with poor prognosis.展开更多
In this paper we discuss the seismogenic structures of the two earthquakes occurring in the Beibu Gulf waters,based on the investigation of geological structure,faults,geophysical fields,seismicity and earthquake foca...In this paper we discuss the seismogenic structures of the two earthquakes occurring in the Beibu Gulf waters,based on the investigation of geological structure,faults,geophysical fields,seismicity and earthquake focal mechanism.The results show that the NEE trending faults along the boundary of the Wushi depression are the dominating seismogenic structures,and the NW trending faults are the key factors of stress concentration.The results also show that high seismicity has a significant relationship with the late Cenozoic deposition center in the Beibu Gulf,and their NE-NEE trending boundary faults are important to the identification of seismogenic structures.The special arcuate fault segment or the intersection point of the NW trending faults and NE-NEE trending boundary faults is a possible location of future earthquakes.展开更多
When an upstream steady uniform supersonic flow impinges onto a symmetric straight-sided wedge,governed by the Euler equations,there are two possible steady oblique shock configurations if the wedge angle is less than...When an upstream steady uniform supersonic flow impinges onto a symmetric straight-sided wedge,governed by the Euler equations,there are two possible steady oblique shock configurations if the wedge angle is less than the detachment angle—the steady weak shock with supersonic or subsonic downstream flow(determined by the wedge angle that is less than or greater than the sonic angle)and the steady strong shock with subsonic downstream flow,both of which satisfy the entropy condition.The fundamental issue—whether one or both of the steady weak and strong shocks are physically admissible solutions—has been vigorously debated over the past eight decades.In this paper,we survey some recent developments on the stability analysis of the steady shock solutions in both the steady and dynamic regimes.For the static stability,we first show how the stability problem can be formulated as an initial-boundary value type problem and then reformulate it into a free boundary problem when the perturbation of both the upstream steady supersonic flow and the wedge boundary are suitably regular and small,and we finally present some recent results on the static stability of the steady supersonic and transonic shocks.For the dynamic stability for potential flow,we first show how the stability problem can be formulated as an initial-boundary value problem and then use the self-similarity of the problem to reduce it into a boundary value problem and further reformulate it into a free boundary problem,and we finally survey some recent developments in solving this free boundary problem for the existence of the PrandtlMeyer configurations that tend to the steady weak supersonic or transonic oblique shock solutions as time goes to infinity.Some further developments and mathematical challenges in this direction are also discussed.展开更多
基金Supported by the National Natural Science Foundation of China(No. 30672737)
文摘OBJECTIVE: To investigate the dynamic changes and relationship of inducible nitric oxide synthase (iNOS) and apoptosis in endotoxin shock rats, as well as the effects of Sini injection. METHODS: In total, 102 Sprague-Dawley (SD) rats were randomly divided into a normal group (n=6, NG), sham operation group (n=24, OG), model group (n=24, MG), dexamethasone group (n=24, DG), and Sini group (n=24, SG). The endotoxin shock model was induced by an intravenous injection of lipopolysaccharide (LPS) (8 mg/kg). Rats in the OG, MG, DG, and SG groups were further divided into 4 groups: 1, 2, 3 and 6 h after shock groups (n=6 per group). iNOS expression was detected by immunohistochemistry. Terminal Deoxynucleotidyl Transferase Mediated Deoxyuridine Triphosphate-biotin Nick End Labeling was employed to measure apoptosis. RESULTS: No iNOS expression was found in the OG group. Compared with the OG group, iNOS expres-sion in the MG group was markedly elevated, reached a peak at 1 h (P<0.01), decreased at 2 and 3 h, and rebounded at 6 h. Compared with the MG group, iNOS expression decreased significantly in both the DG (P<0.05) and SG (P<0.01) groups at 6 h. Thenumberofapoptoticcellsin the MG group was markedly increased than that in the NG and OG (P<0.01) groups, and reached a peak at 6 h. The number of apoptotic cells in the DG group at 1 and 2 h (P<0.01) and SG group at 2, 3 and 6 h (P<0.01) decreased when compared with the MG group. CONCLUSION: Sini injection can significantly inhibit NO generation, which decreases apoptosis and subsequently protects the brain from endotoxic shock.
文摘Objectives To assess the prognostic value of B-type natriuretic peptide （BNP） in severe AMI patients treated with intra-aortic ballon counterpulsation（IABP）. Methods A total of 42 AMI patients with cardiogenic shock were retrospectively studied. BNP plasma level was recorded in the 24th hour and 4th day after myocardial infarction. The different mortality were compared among patients with different BNP levels. Results With aggressive treatment, 20 patients survived short term hospitalization. Plasma concentration of BNP in dying patients is much higher than in survivals（1369 ± 353 vs 651 ± 302 pg/ml. P〈 0.01）.Patients with BNP higher than 1474 pg/mL had a mortality of 92.9 %. Conclusions Elevated BNP level in AMI patients with cardiogenic shock treated with IABP is highly associated with poor prognosis.
基金funded under the special project of earthquake study(200708003) under the National Key Technology R&D Program (2006BAC13B01),China
文摘In this paper we discuss the seismogenic structures of the two earthquakes occurring in the Beibu Gulf waters,based on the investigation of geological structure,faults,geophysical fields,seismicity and earthquake focal mechanism.The results show that the NEE trending faults along the boundary of the Wushi depression are the dominating seismogenic structures,and the NW trending faults are the key factors of stress concentration.The results also show that high seismicity has a significant relationship with the late Cenozoic deposition center in the Beibu Gulf,and their NE-NEE trending boundary faults are important to the identification of seismogenic structures.The special arcuate fault segment or the intersection point of the NW trending faults and NE-NEE trending boundary faults is a possible location of future earthquakes.
基金supported by the US National Science Foundation (Grant Nos. DMS0935967 and DMS-0807551)the UK Engineering and Physical Sciences Research Council (Grant Nos. EP/E035027/1 and EP/L015811/1)+1 种基金National Natural Science Foundation of China (Grant No. 10728101)the Royal Society-Wolfson Research Merit Award (UK)
文摘When an upstream steady uniform supersonic flow impinges onto a symmetric straight-sided wedge,governed by the Euler equations,there are two possible steady oblique shock configurations if the wedge angle is less than the detachment angle—the steady weak shock with supersonic or subsonic downstream flow(determined by the wedge angle that is less than or greater than the sonic angle)and the steady strong shock with subsonic downstream flow,both of which satisfy the entropy condition.The fundamental issue—whether one or both of the steady weak and strong shocks are physically admissible solutions—has been vigorously debated over the past eight decades.In this paper,we survey some recent developments on the stability analysis of the steady shock solutions in both the steady and dynamic regimes.For the static stability,we first show how the stability problem can be formulated as an initial-boundary value type problem and then reformulate it into a free boundary problem when the perturbation of both the upstream steady supersonic flow and the wedge boundary are suitably regular and small,and we finally present some recent results on the static stability of the steady supersonic and transonic shocks.For the dynamic stability for potential flow,we first show how the stability problem can be formulated as an initial-boundary value problem and then use the self-similarity of the problem to reduce it into a boundary value problem and further reformulate it into a free boundary problem,and we finally survey some recent developments in solving this free boundary problem for the existence of the PrandtlMeyer configurations that tend to the steady weak supersonic or transonic oblique shock solutions as time goes to infinity.Some further developments and mathematical challenges in this direction are also discussed.
