Objective: To observe the short￣term efficacy and safety of Shenqi mixture (参芪合剂, SQM) combined with microwave coagulation in treating primary hepatocellular carcinoma (HCC).Methods: Seventy-two patients with pri...Objective: To observe the short￣term efficacy and safety of Shenqi mixture (参芪合剂, SQM) combined with microwave coagulation in treating primary hepatocellular carcinoma (HCC).Methods: Seventy-two patients with primary HCC of stage Ⅱ-Ⅲ, Karnofsky scoring ≥50 scores and predicted survival period ≥3 months were selected and randomly assigned into two groups, the treated group and the control group, 36 in each. Microwave therapy was applied to both groups by double leads, 60 W, 800 sec once a week for two weeks. To the treated group, SQM was given additionally through oral intake of 20 ml, three times a day for 1 month. The changes in tumor size, main symptoms, serum level of alpha-fetoprotein (AFP), immune function and adverse reaction were observed after treatment and the immune parameters of the patients were compared with 30 healthy persons in the normal control group. Results: (1) In the SQM treated group, after treatment 3 patients got completely remitted (CR), 24 partial remitted (PR), 4 unchanged (NC) and 5 progressively deteriorated (PD), the effective rate being 75.00%; while in the control group, 1 got CR, 19 PR, 9 NC and 7 PD, the effective rate being 55.56%. Comparison of the effective rate between the two groups showed significant difference (P<0.05). (2) AFP level decreased after treatment in both groups, but the decrement in the treated group was significantly higher than that in the control group (P<0.01). (3) After treatment, in the treated group, CD3+, CD4+, CD4+/CD8+ and NK activity were improved, Karnofsky scores increased and liver function bettered, with these improvements significantly superior to those in the control group (P<0.01). (4) The improvement in symptoms such as hepatic region pain, fever, weakness, poor appetite and jaundice in the treated group after treatment was also superior to that in the control group (P<0.01). (5)The 12-month, 18-month and 24-month survival rates were higher and the recurrence rate was lower in the treated group than those in the control gro展开更多
目的观察参芪柔脉合剂治疗颈动脉粥样硬化的临床疗效。方法将确诊为颈动脉粥样硬化的98例患者随机分为治疗组50例和对照组48例。治疗组给予参芪柔脉合剂(100 m L/次,2次/d)及辛伐他汀胶囊(20 mg/次,1次/晚)口服,对照组仅给予辛伐他汀胶...目的观察参芪柔脉合剂治疗颈动脉粥样硬化的临床疗效。方法将确诊为颈动脉粥样硬化的98例患者随机分为治疗组50例和对照组48例。治疗组给予参芪柔脉合剂(100 m L/次,2次/d)及辛伐他汀胶囊(20 mg/次,1次/晚)口服,对照组仅给予辛伐他汀胶囊(20 mg/次,1次/晚)口服,2组均持续用药24周。观察2组治疗前后颈动脉IMT、Crouse积分、中医证候积分及血脂、血清白细胞介素(IL-6)水平变化情况,统计2组临床疗效及不良反应发生情况。结果治疗组颈动脉斑块Crouse积分、中医证候积分、血脂、血清IL-6水平改善情况均明显优于对照组(P均<0.05),临床总有效率明显高于对照组(P<0.05)。2组均无明显不良反应发生。结论参芪柔脉合剂能有效改善颈动脉粥样硬化患者的症状体征,降低血脂水平及炎症因子水平,提高临床疗效,值得推广应用。展开更多
基金Fund for Young Researchers Set by Ministry of Health of Fujian Province(No.2002-2-20)
文摘Objective: To observe the short￣term efficacy and safety of Shenqi mixture (参芪合剂, SQM) combined with microwave coagulation in treating primary hepatocellular carcinoma (HCC).Methods: Seventy-two patients with primary HCC of stage Ⅱ-Ⅲ, Karnofsky scoring ≥50 scores and predicted survival period ≥3 months were selected and randomly assigned into two groups, the treated group and the control group, 36 in each. Microwave therapy was applied to both groups by double leads, 60 W, 800 sec once a week for two weeks. To the treated group, SQM was given additionally through oral intake of 20 ml, three times a day for 1 month. The changes in tumor size, main symptoms, serum level of alpha-fetoprotein (AFP), immune function and adverse reaction were observed after treatment and the immune parameters of the patients were compared with 30 healthy persons in the normal control group. Results: (1) In the SQM treated group, after treatment 3 patients got completely remitted (CR), 24 partial remitted (PR), 4 unchanged (NC) and 5 progressively deteriorated (PD), the effective rate being 75.00%; while in the control group, 1 got CR, 19 PR, 9 NC and 7 PD, the effective rate being 55.56%. Comparison of the effective rate between the two groups showed significant difference (P<0.05). (2) AFP level decreased after treatment in both groups, but the decrement in the treated group was significantly higher than that in the control group (P<0.01). (3) After treatment, in the treated group, CD3+, CD4+, CD4+/CD8+ and NK activity were improved, Karnofsky scores increased and liver function bettered, with these improvements significantly superior to those in the control group (P<0.01). (4) The improvement in symptoms such as hepatic region pain, fever, weakness, poor appetite and jaundice in the treated group after treatment was also superior to that in the control group (P<0.01). (5)The 12-month, 18-month and 24-month survival rates were higher and the recurrence rate was lower in the treated group than those in the control gro
文摘目的观察参芪柔脉合剂治疗颈动脉粥样硬化的临床疗效。方法将确诊为颈动脉粥样硬化的98例患者随机分为治疗组50例和对照组48例。治疗组给予参芪柔脉合剂(100 m L/次,2次/d)及辛伐他汀胶囊(20 mg/次,1次/晚)口服,对照组仅给予辛伐他汀胶囊(20 mg/次,1次/晚)口服,2组均持续用药24周。观察2组治疗前后颈动脉IMT、Crouse积分、中医证候积分及血脂、血清白细胞介素(IL-6)水平变化情况,统计2组临床疗效及不良反应发生情况。结果治疗组颈动脉斑块Crouse积分、中医证候积分、血脂、血清IL-6水平改善情况均明显优于对照组(P均<0.05),临床总有效率明显高于对照组(P<0.05)。2组均无明显不良反应发生。结论参芪柔脉合剂能有效改善颈动脉粥样硬化患者的症状体征,降低血脂水平及炎症因子水平,提高临床疗效,值得推广应用。
