Background: The transmission and fatal risk of severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease first discovered in China in 2009, still needed further quantification. This research a...Background: The transmission and fatal risk of severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease first discovered in China in 2009, still needed further quantification. This research aimed to analyze the SFTS clusters and assess the transmission and mortality risk for SFTS.Methods: Both epidemiological investigation and case reports regarding SFTS clusters in China during 2011-2021 were obtained from the Public Health Emergency Information Management System of the Chinese Center for Disease Control and Prevention Information System. The transmission risk was evaluated by using the secondary attack rate (SAR) and relative risk (RR). Mortality risk factors were analyzed using a logistic regression model.Results: There were 35 SFTS clusters during 2011-2021 involving 118 patients with a fatality rate of 22.0%. The number of clusters annually increased seasonally from April to September. The clusters mainly occurred in Anhui (16 clusters) and Shandong provinces (8 clusters). The SAR through contact with blood or bloody fluids was much higher than that through contact with non-bloody fluids (50.6% vs 3.0%;χ^(2) = 210.97,P < 0.05), with anRR of 16.61 [95% confidence interval (CI): 10.23-26.97]. There was a statistically significant difference in the SAR between exposure to the blood of a deceased person during burial preparation and exposure to the living patients’ blood (66.7% vs 34.5%;χ^(2)= 6.40,P < 0.05), with anRR of 1.93 (95%CI: 1.11-3.37). The mortality risk factors were a long interval from onset to diagnosis [odds ratio (OR)= 1.385), 95%CI: 1.083-1.772,P= 0.009) and advanced age (OR: 1.095, 95%CI: 1.031-1.163,P= 0.01).Conclusions: The SFTS clusters showed a high mortality rate and resulted in a high SAR. Contact with a bleeding corpse was associated with a higher infection risk, compared with contacting the blood from living patients. It is important to promote early detection and appropriate case management of patients with SFTS, as well as improved handling of their corps展开更多
目的:探究中重度支气管哮喘急性发作期患儿呼出气一氧化氮(Fe NO)表达水平与肺功能的相关性。方法:选择2016年3月-2019年3月来我院就诊的中重度支气管哮喘急性发作期患儿69例为观察组,其中,中度支气管哮喘急性发作期患儿58例,重度支气...目的:探究中重度支气管哮喘急性发作期患儿呼出气一氧化氮(Fe NO)表达水平与肺功能的相关性。方法:选择2016年3月-2019年3月来我院就诊的中重度支气管哮喘急性发作期患儿69例为观察组,其中,中度支气管哮喘急性发作期患儿58例,重度支气管哮喘急性发作期患儿11例;另选取同期来我院体检的69例正常健康儿童作为对照组,对比观察组中中度、重度支气管哮喘急性发作期患儿Fe NO表达水平、用力肺活量(forced vital capacity,FVC)、最大呼气流量占预计值百分比(Maximum expiratory flow as a percentage of expected value,PEF%)、第一秒用力呼气容积占预计值的百分比(Forced expiratory volume as a percentage of expected value in the first second,FEV1%)与对照组健康儿童的差异,并对观察组患儿Fe NO表达水平与肺功能的相关性进行分析。结果:观察组患儿的Fe NO表达水平均高于对照组,且重度组患儿的Fe NO表达水平明显高于中度组(P<0.05);观察组患儿的PEF%、FEV1%、FVC水平均高于对照组,且重度组患儿的PEF%、FEV1%、FVC水平均高于中度组(P<0.05);观察组患儿Fe NO表达水平与FVC、PEF%、FEV1%指标均呈负相关关系(r=-0.503、-0.551、-0.532,P均<0.05)。结论:中重度支气管哮喘急性发作期患儿Fe NO表达水平与肺功能成负相关,可通过监测Fe NO水平间接判断炎症程度。展开更多
基金QC acknowledges the support provided by the National Science and Technology Major Project of China(2018ZX10101002-003-002)YZ and ZYS acknowledge the support provided by the Public Health Emergency Response Mechanism Operation Program of Chinese Center for Disease Control and Prevention(131031001000210001).
文摘Background: The transmission and fatal risk of severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease first discovered in China in 2009, still needed further quantification. This research aimed to analyze the SFTS clusters and assess the transmission and mortality risk for SFTS.Methods: Both epidemiological investigation and case reports regarding SFTS clusters in China during 2011-2021 were obtained from the Public Health Emergency Information Management System of the Chinese Center for Disease Control and Prevention Information System. The transmission risk was evaluated by using the secondary attack rate (SAR) and relative risk (RR). Mortality risk factors were analyzed using a logistic regression model.Results: There were 35 SFTS clusters during 2011-2021 involving 118 patients with a fatality rate of 22.0%. The number of clusters annually increased seasonally from April to September. The clusters mainly occurred in Anhui (16 clusters) and Shandong provinces (8 clusters). The SAR through contact with blood or bloody fluids was much higher than that through contact with non-bloody fluids (50.6% vs 3.0%;χ^(2) = 210.97,P < 0.05), with anRR of 16.61 [95% confidence interval (CI): 10.23-26.97]. There was a statistically significant difference in the SAR between exposure to the blood of a deceased person during burial preparation and exposure to the living patients’ blood (66.7% vs 34.5%;χ^(2)= 6.40,P < 0.05), with anRR of 1.93 (95%CI: 1.11-3.37). The mortality risk factors were a long interval from onset to diagnosis [odds ratio (OR)= 1.385), 95%CI: 1.083-1.772,P= 0.009) and advanced age (OR: 1.095, 95%CI: 1.031-1.163,P= 0.01).Conclusions: The SFTS clusters showed a high mortality rate and resulted in a high SAR. Contact with a bleeding corpse was associated with a higher infection risk, compared with contacting the blood from living patients. It is important to promote early detection and appropriate case management of patients with SFTS, as well as improved handling of their corps
文摘目的:探究中重度支气管哮喘急性发作期患儿呼出气一氧化氮(Fe NO)表达水平与肺功能的相关性。方法:选择2016年3月-2019年3月来我院就诊的中重度支气管哮喘急性发作期患儿69例为观察组,其中,中度支气管哮喘急性发作期患儿58例,重度支气管哮喘急性发作期患儿11例;另选取同期来我院体检的69例正常健康儿童作为对照组,对比观察组中中度、重度支气管哮喘急性发作期患儿Fe NO表达水平、用力肺活量(forced vital capacity,FVC)、最大呼气流量占预计值百分比(Maximum expiratory flow as a percentage of expected value,PEF%)、第一秒用力呼气容积占预计值的百分比(Forced expiratory volume as a percentage of expected value in the first second,FEV1%)与对照组健康儿童的差异,并对观察组患儿Fe NO表达水平与肺功能的相关性进行分析。结果:观察组患儿的Fe NO表达水平均高于对照组,且重度组患儿的Fe NO表达水平明显高于中度组(P<0.05);观察组患儿的PEF%、FEV1%、FVC水平均高于对照组,且重度组患儿的PEF%、FEV1%、FVC水平均高于中度组(P<0.05);观察组患儿Fe NO表达水平与FVC、PEF%、FEV1%指标均呈负相关关系(r=-0.503、-0.551、-0.532,P均<0.05)。结论:中重度支气管哮喘急性发作期患儿Fe NO表达水平与肺功能成负相关,可通过监测Fe NO水平间接判断炎症程度。
文摘目的探究及观察白葡奈氏菌片联合吸入糖皮质激素+长效β2受体激动剂(inhaled corticosteroid+long-acting β_(2)-agonist,ICS+LABA)治疗中重度慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)急性发作的疗效及对生活质量的影响。方法将2020年6月—2021年12月山东第一医科大学附属省立医院的80例中重度COPD急性发作患者根据随机数字表法分为2组。对照组的40例采用ICS+LABA进行治疗,观察组的40例则在对照组的基础上加用白葡奈氏菌片。比较2组的COPD治疗总有效率、不良反应发生率、治疗前后的症状体征积分、疾病状态[慢性阻塞性肺疾病评分(COPD assessment test,CAT评分)]及生活质量[世界卫生组织生存质量测定量表简表(World Health Organization on quality of life brief scale,WHOQOL-BREF评分)]。结果治疗1、2周后观察组的COPD治疗总有效率显著高于对照组,差异有统计学意义(P<0.05),2组的不良反应发生率比较,差异无统计学意义(P>0.05),治疗1、2周后观察组的COPD相关症状体征积分显著低于对照组,CAT评分构成则显著优于对照组,WHOQOL-BREF评分显著高于对照组,差异有统计学意义(P<0.05)。结论白葡奈氏菌片联合ICS+LABA治疗中重度COPD急性发作的疗效较好,且可显著改善患者的生活质量。
