背景:目前,自体髂骨移植被广泛认为是治疗骨缺损的"金标准";然而,髂嵴供骨区常出现并发症,限制了其在临床上的推广使用。目的:采用循证医学研究方法,对已发表相关文献进行汇总分析,总结自体髂骨植骨后供骨区并发症的种类及发...背景:目前,自体髂骨移植被广泛认为是治疗骨缺损的"金标准";然而,髂嵴供骨区常出现并发症,限制了其在临床上的推广使用。目的:采用循证医学研究方法,对已发表相关文献进行汇总分析,总结自体髂骨植骨后供骨区并发症的种类及发生率。方法:检索Pub Med Medline、Ovid Medline、Cochrane Database、Embase Database等数据库,检索时间范围:2002年1月至2011年12月,以"Iliac crest bone graft"或"autologous bone graft"或"bone graft donor site"或"complication"或"Morbidity"为检索词,共检索到174篇文献。根据检索条件及评价标准,最终筛选出30篇临床研究报道进行Meta分析,共计2476例患者。采用SPSS13.0和R软件及其Meta程序包对检索结果进行统计分析。结果与结论:自体髂骨植骨后供骨区主要并发症包括供骨区≥6个月长期疼痛(发生率=7.88%,95%可信区间4.76%-12.79%)、供骨区感染(发生率=4.26%,95%可信区间2.95%-6.12%)、血肿及血清肿(发生率=6.55%,95%可信区间4.90%-8.70%)、神经损伤(发生率=5.85%,95%可信区间3.46%-9.71%)、感觉障碍(发生率=10.1%,95%可信区间6.07%-16.23%)。可见髂骨取骨后并发症发生率较高,临床医师应予以重视。展开更多
The primary purpose of this article was to review the current literature regarding the clinical consequences of centipede envenomation in humans,in order to determine whether the bite of these arthropods is neurotoxic...The primary purpose of this article was to review the current literature regarding the clinical consequences of centipede envenomation in humans,in order to determine whether the bite of these arthropods is neurotoxic to humans or not. A thorough search of the literature regarding the clinical consequences of centipede bites in humans was applied,with great respect to neurological symptoms potentially caused by such bites. Centipede bite commonly causes only local reactions,which usually resolve within a few days without sequelae. The patients in the majority of centipede envenomations describe a painful but benign syndrome. However,mild constitutional symptoms are relatively frequent. Remarkably,centipedes can rarely cause severe systematic reactions such as anaphylaxis or even hypotension and myocardial ischemia. Factors such as patient age,comorbidity,anatomic site of envenomation,and size/species of centipede should be considered when evaluating a centipede envenomation victim. According to the current literature,the centipede bite does not seem to be neurotoxic to humans. However,it commonly causes symptoms mediated by the nervous system. These include local and generalized symptoms,with the first dominated by sensory disturbances and the second by non-specific symptoms such as headache,anxiety and presyncope. Based on our results,the answer to our study's question is negative. The centipede bite is not neurotoxic to humans. However,it commonly causes symptoms mediated by the nervous system,which include primarily local pain and sensory disturbances,as well as generalized non-specific symptoms such as headache,anxiety and vagotonia.展开更多
文摘背景:目前,自体髂骨移植被广泛认为是治疗骨缺损的"金标准";然而,髂嵴供骨区常出现并发症,限制了其在临床上的推广使用。目的:采用循证医学研究方法,对已发表相关文献进行汇总分析,总结自体髂骨植骨后供骨区并发症的种类及发生率。方法:检索Pub Med Medline、Ovid Medline、Cochrane Database、Embase Database等数据库,检索时间范围:2002年1月至2011年12月,以"Iliac crest bone graft"或"autologous bone graft"或"bone graft donor site"或"complication"或"Morbidity"为检索词,共检索到174篇文献。根据检索条件及评价标准,最终筛选出30篇临床研究报道进行Meta分析,共计2476例患者。采用SPSS13.0和R软件及其Meta程序包对检索结果进行统计分析。结果与结论:自体髂骨植骨后供骨区主要并发症包括供骨区≥6个月长期疼痛(发生率=7.88%,95%可信区间4.76%-12.79%)、供骨区感染(发生率=4.26%,95%可信区间2.95%-6.12%)、血肿及血清肿(发生率=6.55%,95%可信区间4.90%-8.70%)、神经损伤(发生率=5.85%,95%可信区间3.46%-9.71%)、感觉障碍(发生率=10.1%,95%可信区间6.07%-16.23%)。可见髂骨取骨后并发症发生率较高,临床医师应予以重视。
文摘The primary purpose of this article was to review the current literature regarding the clinical consequences of centipede envenomation in humans,in order to determine whether the bite of these arthropods is neurotoxic to humans or not. A thorough search of the literature regarding the clinical consequences of centipede bites in humans was applied,with great respect to neurological symptoms potentially caused by such bites. Centipede bite commonly causes only local reactions,which usually resolve within a few days without sequelae. The patients in the majority of centipede envenomations describe a painful but benign syndrome. However,mild constitutional symptoms are relatively frequent. Remarkably,centipedes can rarely cause severe systematic reactions such as anaphylaxis or even hypotension and myocardial ischemia. Factors such as patient age,comorbidity,anatomic site of envenomation,and size/species of centipede should be considered when evaluating a centipede envenomation victim. According to the current literature,the centipede bite does not seem to be neurotoxic to humans. However,it commonly causes symptoms mediated by the nervous system. These include local and generalized symptoms,with the first dominated by sensory disturbances and the second by non-specific symptoms such as headache,anxiety and presyncope. Based on our results,the answer to our study's question is negative. The centipede bite is not neurotoxic to humans. However,it commonly causes symptoms mediated by the nervous system,which include primarily local pain and sensory disturbances,as well as generalized non-specific symptoms such as headache,anxiety and vagotonia.
