Tumor angiogenesis is closely related to tumor development,immune escape,and drug resistance.Therefore,the development of effective anti-tumor angiogenesis drugs is of great research significance.Although the current ...Tumor angiogenesis is closely related to tumor development,immune escape,and drug resistance.Therefore,the development of effective anti-tumor angiogenesis drugs is of great research significance.Although the current clinical angiogenesis inhibitors have achieved certain efficacy,they also pose the problems of limited and short duration of efficacy,drug resistance,and intrinsic toxicity.Anti-tumor angiogenesis strategies targeting endothelial cells(ECs)have attracted widespread attention in the development of highly effective and low toxicity anti-angiogenesis inhibitors.Studies have verified that the trace element selenium(Se)can inhibit tumor growth by inhibiting tumor angiogenesis through different mechanisms.Nevertheless,it is unclear whether Se speciation has different effects on anti-tumor angiogenesis.Herein,we found that Se exhibited effective anti-angiogenic activity,and its mechanisms of activity were determined by its chemical speciation.Organic Se can significantly inhibit tumor angiogenesis by targeting thioredoxin reductase(TrxR)to trigger cell apoptosis and cell cycle arrest and by increasing reactive oxygen species(ROS)production in ECs.Inorganic Se can induce cell cycle arrest and increase ROS production in ECs,showing promising anti-angiogenic effects.Se nanoparticles(SeNPs)slightly inhibit tumor angiogenesis by inducing apoptosis and cell cycle arrest and by increasing the production of ROS.In summary,this study elucidates the anti-angiogenic activity of Se speciation control with a view to providing a scientific reference for the design and development of novel Se-based highly effective and low toxicity angiogenesis inhibitors.展开更多
Two species of Minooa are revised from China and Southeast Asia,and one of these,Minooa carinata Qi,Bae&Li,sp.nov.is described as new to science,and M.acantha Qi,2016 is newly recorded from Vietnam.Photographs of ...Two species of Minooa are revised from China and Southeast Asia,and one of these,Minooa carinata Qi,Bae&Li,sp.nov.is described as new to science,and M.acantha Qi,2016 is newly recorded from Vietnam.Photographs of adults,male and female genitalia are provided,along with a key for all species of Minooa.展开更多
Selenium （Se） is an important element from the environmental and biological point of view. In the world, deficiency of Se in a diet occurs more often and nutritional supplements are recommended.The ability of severa...Selenium （Se） is an important element from the environmental and biological point of view. In the world, deficiency of Se in a diet occurs more often and nutritional supplements are recommended.The ability of several plants to accumulate and transform inorganic Se forms into its bioactive organic compounds has important implications for human nutrition and health. This work gives a brief overview of the study carried out to characterize Se species produced by different enriched edible plants which were grown in the presence of different Se species.展开更多
基金funded by Science and Technology Projects in Guangzhou(No.202102010083)National Natural Science Foundation of China(No.32201062)Guangzhou Basic and Applied Basic Research Foundation(No.202201010339).
文摘Tumor angiogenesis is closely related to tumor development,immune escape,and drug resistance.Therefore,the development of effective anti-tumor angiogenesis drugs is of great research significance.Although the current clinical angiogenesis inhibitors have achieved certain efficacy,they also pose the problems of limited and short duration of efficacy,drug resistance,and intrinsic toxicity.Anti-tumor angiogenesis strategies targeting endothelial cells(ECs)have attracted widespread attention in the development of highly effective and low toxicity anti-angiogenesis inhibitors.Studies have verified that the trace element selenium(Se)can inhibit tumor growth by inhibiting tumor angiogenesis through different mechanisms.Nevertheless,it is unclear whether Se speciation has different effects on anti-tumor angiogenesis.Herein,we found that Se exhibited effective anti-angiogenic activity,and its mechanisms of activity were determined by its chemical speciation.Organic Se can significantly inhibit tumor angiogenesis by targeting thioredoxin reductase(TrxR)to trigger cell apoptosis and cell cycle arrest and by increasing reactive oxygen species(ROS)production in ECs.Inorganic Se can induce cell cycle arrest and increase ROS production in ECs,showing promising anti-angiogenic effects.Se nanoparticles(SeNPs)slightly inhibit tumor angiogenesis by inducing apoptosis and cell cycle arrest and by increasing the production of ROS.In summary,this study elucidates the anti-angiogenic activity of Se speciation control with a view to providing a scientific reference for the design and development of novel Se-based highly effective and low toxicity angiogenesis inhibitors.
文摘Two species of Minooa are revised from China and Southeast Asia,and one of these,Minooa carinata Qi,Bae&Li,sp.nov.is described as new to science,and M.acantha Qi,2016 is newly recorded from Vietnam.Photographs of adults,male and female genitalia are provided,along with a key for all species of Minooa.
文摘Selenium （Se） is an important element from the environmental and biological point of view. In the world, deficiency of Se in a diet occurs more often and nutritional supplements are recommended.The ability of several plants to accumulate and transform inorganic Se forms into its bioactive organic compounds has important implications for human nutrition and health. This work gives a brief overview of the study carried out to characterize Se species produced by different enriched edible plants which were grown in the presence of different Se species.
