本实验对比研究了中药巴戟天、鄂西巴戟天和川巴戟的某些补虚扶正和助阳的作用及其毒性,口服巴戟天和鄂西巴戟天水煎液能显著增加小白鼠体重、延长持续游泳时间、抑制幼年小鼠胸腺萎缩、升高其血中白细胞数,并能增加甲状腺功能低下(甲减...本实验对比研究了中药巴戟天、鄂西巴戟天和川巴戟的某些补虚扶正和助阳的作用及其毒性,口服巴戟天和鄂西巴戟天水煎液能显著增加小白鼠体重、延长持续游泳时间、抑制幼年小鼠胸腺萎缩、升高其血中白细胞数,并能增加甲状腺功能低下(甲减)小鼠的耗氧量,使甲减小鼠脑中升高的 M 受体最大结合容量恢复正常。作用强度以巴戟天尤佳,川巴戟水煎剂效果不明显。大白鼠口服三种巴戟天水煎剂未见雄性激素样作用;经小鼠口服给药未见急性毒性;经大肠杆菌体外 SOS 比色分析亦未见有致诱变作用。展开更多
Eight dibenzocyclooctadiene lignans were isolated from the stems of Schisandra propinqua(Wall.)Hook. f. et Thoms. Their structures were elucidated as acetylgomisin R(1), angeloylgomisin R(2), gomisins A(3), B(4), N(5)...Eight dibenzocyclooctadiene lignans were isolated from the stems of Schisandra propinqua(Wall.)Hook. f. et Thoms. Their structures were elucidated as acetylgomisin R(1), angeloylgomisin R(2), gomisins A(3), B(4), N(5) and O(6), 6 O benzoylgomosin O(7) and schisantherin A(8) by spectral studies. Among them, compound 1 was a new one, compound 2 was discovered in the genus Schisandra for the first time and the others were originally isolated from Schisandra propinqua .展开更多
In the course of our study of bioactive natural products from Schisandra plants, we isolated a neolignan from an EtOAc extract of the stems of Schisandra propinqua （Wall.） Baill. The structure of the new com- pound ...In the course of our study of bioactive natural products from Schisandra plants, we isolated a neolignan from an EtOAc extract of the stems of Schisandra propinqua （Wall.） Baill. The structure of the new com- pound was determined to be 4, 4-di （4-hydroxy-3-methoxyphenly）-2, 3-dimethylbutanol （compound 1） on the basis of 1H- and 13C-NMR spectra and 2D NMR methods. Eight known compounds, compounds 2-9, were also isolated and identified, of which compounds 3, 4, 6 and 9 were isolated for the first time from this plant. In addition, compounds 1-4 were evaluated for cytotoxicity by an 3-（4,5-dimethyl-2 thiazoyl）-2,5-diphenyl-2H- tetrazolium bromide （MTT） assay. Compound 1 showed significant potential cytotoxic ability in the bioassay.展开更多
A new cinnamic acid monoterpenoid ester, intermedin C （1）, was isolated from the aerial parts of Schisandra propinqua var. interthedia. The structure of 1 was elucidated by spectroscopic methods including extensive ...A new cinnamic acid monoterpenoid ester, intermedin C （1）, was isolated from the aerial parts of Schisandra propinqua var. interthedia. The structure of 1 was elucidated by spectroscopic methods including extensive ^1D and 2D NMR techniques.展开更多
文摘本实验对比研究了中药巴戟天、鄂西巴戟天和川巴戟的某些补虚扶正和助阳的作用及其毒性,口服巴戟天和鄂西巴戟天水煎液能显著增加小白鼠体重、延长持续游泳时间、抑制幼年小鼠胸腺萎缩、升高其血中白细胞数,并能增加甲状腺功能低下(甲减)小鼠的耗氧量,使甲减小鼠脑中升高的 M 受体最大结合容量恢复正常。作用强度以巴戟天尤佳,川巴戟水煎剂效果不明显。大白鼠口服三种巴戟天水煎剂未见雄性激素样作用;经小鼠口服给药未见急性毒性;经大肠杆菌体外 SOS 比色分析亦未见有致诱变作用。
文摘Eight dibenzocyclooctadiene lignans were isolated from the stems of Schisandra propinqua(Wall.)Hook. f. et Thoms. Their structures were elucidated as acetylgomisin R(1), angeloylgomisin R(2), gomisins A(3), B(4), N(5) and O(6), 6 O benzoylgomosin O(7) and schisantherin A(8) by spectral studies. Among them, compound 1 was a new one, compound 2 was discovered in the genus Schisandra for the first time and the others were originally isolated from Schisandra propinqua .
文摘In the course of our study of bioactive natural products from Schisandra plants, we isolated a neolignan from an EtOAc extract of the stems of Schisandra propinqua （Wall.） Baill. The structure of the new com- pound was determined to be 4, 4-di （4-hydroxy-3-methoxyphenly）-2, 3-dimethylbutanol （compound 1） on the basis of 1H- and 13C-NMR spectra and 2D NMR methods. Eight known compounds, compounds 2-9, were also isolated and identified, of which compounds 3, 4, 6 and 9 were isolated for the first time from this plant. In addition, compounds 1-4 were evaluated for cytotoxicity by an 3-（4,5-dimethyl-2 thiazoyl）-2,5-diphenyl-2H- tetrazolium bromide （MTT） assay. Compound 1 showed significant potential cytotoxic ability in the bioassay.
基金supported by the National Natural Science Foundation of China (No.20402016)a Foundation for the Author of National Excellent Doctoral Dissertation of PR China (No.200780)+2 种基金a Foundation for the Author of Excellent Doctoral Dissertation of Chinese Academy of Sciences (No.00602551221)the Program for New Century Excellent Talents on University (No.NCET-06-0824)the Young Academic and Technical Leader Raising Foundation of Yunnan Province (No.2005py01-32).
文摘A new cinnamic acid monoterpenoid ester, intermedin C （1）, was isolated from the aerial parts of Schisandra propinqua var. interthedia. The structure of 1 was elucidated by spectroscopic methods including extensive ^1D and 2D NMR techniques.
