OBJECTIVE: To observe the effect of Sancaijiangtang powders on plasma nitric oxide and endothelin-1 levels. We sought to identify the common pathological link and mechanism of action for Traditional Chinese medicine i...OBJECTIVE: To observe the effect of Sancaijiangtang powders on plasma nitric oxide and endothelin-1 levels. We sought to identify the common pathological link and mechanism of action for Traditional Chinese medicine in type 2 diabetes mellitus and vascular dementia,and to explicate the material basis for treating the different diseases with the same method in Traditional Chinese Medicine.METHODS: In total,168 patients with type 2 diabetes mellitus and vascular dementia were enrolled in the study,and randomly divided into two groups by simple randomization. Patients in the treatment group received oral Sancaijiangtang powders with pioglitazone hydrochloride three times daily,while patients in the control group received pioglitazone hydrochloride alone. The treatment course was for12 weeks. Mini-mental state examinations(Chinese version) and Montreal Cognitive Assessments(Beijing version) were performed,and fasting plasma glucose,fasting insulin,hemoglobin A1 c,homeostasis model assessment of insulin resistance,plasma nitric oxide and endothelin-1 levels were measured before and after the treatment.RESULTS: The post-treatment levels for all measurements in both groups were better than pre-treatment levels(P < 0.05). The post-treatment levels for all measurements in the treatment group were better than the levels measured in the control group(P < 0.05).CONCLUSION: Type 2 diabetes mellitus and vascular dementia have common pathological mechanisms for insulin resistance and endothelium dysfunction. Sancaijiangtang powders could improve the release of nitric oxide and inhibit the secretion of endothelin-1. Therefore,the material basis exists for treating the different diseases with the same method in Traditional Chinese Medicine.展开更多
In this paper, the author analyses the wooden drum dance from thesacrificial activity of Miao Slanghtering cattle to "eat gu zang" by the princi-ple and method of "dance ecology", On the other hand...In this paper, the author analyses the wooden drum dance from thesacrificial activity of Miao Slanghtering cattle to "eat gu zang" by the princi-ple and method of "dance ecology", On the other hand, he expounds the im-pact of modern culture on the dance.展开更多
That more than 82 percent of proved sandstone-type uranium deposits coexist with proved oil-gas or coalfields in the world reflects the fact of coexistence and accumulation of multi-energy minerals including oil,gas,c...That more than 82 percent of proved sandstone-type uranium deposits coexist with proved oil-gas or coalfields in the world reflects the fact of coexistence and accumulation of multi-energy minerals including oil,gas,coal and uranium in the same basin.Especially,this phenomenon is most typical in the Central-east Asia energy basins.Across China,Mongolia and some central Asian countries,the giant Central-east Asia metallogenetic domain(CEAMD)stretches more than 6,000 km from Songliao Basin of China in the east to the Caspian Sea in the west.The multi-energy minerals distribution characteristics of the domain include:their spatial distribution is complicated and ordered;the ore-bearing horizon relates closely to the geographical region;the accumulation/mineralization and localization time is the same or close;the occurrence setting and accumulation/mineralization have close correlation;and they have rich provenance for all the minerals.All of these imply that they have close relations between each other under a unified geodynamic background.The exogenetic uranium mineralization process in CEAMD can be divided into five phases using time limits of 100 Ma,(50±2)Ma,20±(2―4)Ma,8―5 Ma.The major mineralization periods and their differences in each primary uranium-bearing basin are identical to the oil-gas accumulation and localization periods and phases in the same basin,and are also in response to regional tectonics and controlled in general by the regional geodynamic environment.For industrial application and commercial exploitation,it is suggested that an important period for coexistence,accumulation and localization of oil,gas,coal and uranium and their interaction mainly occur in the late/last and post basin evolution.Through generalized analysis and comparison of accumulation/mineralization environment of the energy basins in CEAMD,the authors propose that the relatively stable regional tectonic background and moderate(weaker)structural deformation probably are necessary for formation,coexistence and preservat展开更多
Based on the model of the same degree of all nodes we proposed before, a new algorithm, the so-called “spread all over vertices” （SAV） algorithm, is proposed for generating small-world properties from a regular ri...Based on the model of the same degree of all nodes we proposed before, a new algorithm, the so-called “spread all over vertices” （SAV） algorithm, is proposed for generating small-world properties from a regular ring lattices. During randomly rewiring connections the SAV is used to keep the unchanged number of links. Comparing the SAV algorithm with the Watts-Strogatz model and the “spread all over boundaries” algorithm, three methods can have the same topological properties of the small world networks. These results offer diverse formation of small world networks. It is helpful to the research of some applications for dynamics of mutual oscillator inside nodes and interacting automata associated with networks.展开更多
Objective: "Same treatment for different diseases" is a unique treatment strategy under the guidance of traditional Chinese medicine(TCM) theory.Codonopsis Radix(Codonopsis pilosula,Dangshen in Chinese)with ...Objective: "Same treatment for different diseases" is a unique treatment strategy under the guidance of traditional Chinese medicine(TCM) theory.Codonopsis Radix(Codonopsis pilosula,Dangshen in Chinese)with spleen-fortifying effect was employed to understand the strategy of "Same treatment for different diseases",based on its common mechanism in the treatment of gastric diseases including gastric ulcer,gastritis and gastric cancer via network pharmacology research.Methods:Network pharmacology research methods were used to analyze the interaction network and potential mechanisms of Dangshen in treating gastric ulcer,gastritis and gastric cancer.The active components and their target proteins of Dangshen were integrated from TCMSP,BATMAN-TCM databases.The targets of gastric ulcer,gastritis and gastric cancer were collected through GeneCards,PubMed,TDD and DisGeNET Database.Through screening,the key components and the key targets of Dangshen in treating gastric ulcer,gastritis and gastric cancer were obtained.After KEGG pathway analysis and GO analysis,the important pathways and biological processes were analyzed.Results:Through data and literature mining,the common and specific pharmaceutical effects and mechanism of Dangshen were summarized in these three gastric lesions.It was shown that Dangshen mainly acted on gastric ulcer,gastritis and gastric cancer through the overall regulation of the PI3K-AkT signaling pathway.With the development of the disease,it will gradually increase the control of inflammation through TNF,NF-κB and other inflammation-related signaling pathways to reduce inflammatory damage.For tumorigenesis,it pays more attention to inhibiting the ErbB signaling pathways to reduce the proliferation and migration of tumor cells.In addition,Dangshen's regulation of HIF-1 signaling pathway may also be beneficial for the treatment of gastric ulcer,gastritis and gastric cancer.Conclusion:Dangshen achieves spleen-fortifying effect on gastric diseases including gastric ulcer,gastritis and gastric cancer t展开更多
Objective： To identify the commonalities between rheumatoid arthritis （RA） and diabetes mellitus （DM） to understand the mechanisms of Chinese medicine （CM） in different diseases with the same treatment. Methods...Objective： To identify the commonalities between rheumatoid arthritis （RA） and diabetes mellitus （DM） to understand the mechanisms of Chinese medicine （CM） in different diseases with the same treatment. Methods： A text mining approach was adopted to analyze the commonalities between RA and DM according to CM and biological elements. The major commonalities were subsequently verified in RA and DM rat models, in which herbal formula for the treatment of both RA and DM identified via text mining was used as the intervention. Results： Similarities were identified between RA and DM regarding the CM approach used for diagnosis and treatment, as well as the networks of biological activities affected by each disease, including the involvement of adhesion molecules, oxidative stress, cytokines, T-lymphocytes, apoptosis, and inflammation. The Ramulus Cinnamomi-Radix Paeoniae Alba-Rhizoma Anemarrhenae is an herbal combination used to treat RA and DM. This formula demonstrated similar effects on oxidative stress and inflammation in rats with collagen-induced arthritis, which supports the text mining results regarding the commonalities between RA and DM. Conclusion： Commonalities between the biological activities involved in RA and DM were identified through text mining, and both RA and DM might be responsive to the same intervention at a specific stage.展开更多
基金Supported by Research Project for Practice Development of National Traditional Chinese Medicine Clinical Research Bases(No.JDZX2012128)
文摘OBJECTIVE: To observe the effect of Sancaijiangtang powders on plasma nitric oxide and endothelin-1 levels. We sought to identify the common pathological link and mechanism of action for Traditional Chinese medicine in type 2 diabetes mellitus and vascular dementia,and to explicate the material basis for treating the different diseases with the same method in Traditional Chinese Medicine.METHODS: In total,168 patients with type 2 diabetes mellitus and vascular dementia were enrolled in the study,and randomly divided into two groups by simple randomization. Patients in the treatment group received oral Sancaijiangtang powders with pioglitazone hydrochloride three times daily,while patients in the control group received pioglitazone hydrochloride alone. The treatment course was for12 weeks. Mini-mental state examinations(Chinese version) and Montreal Cognitive Assessments(Beijing version) were performed,and fasting plasma glucose,fasting insulin,hemoglobin A1 c,homeostasis model assessment of insulin resistance,plasma nitric oxide and endothelin-1 levels were measured before and after the treatment.RESULTS: The post-treatment levels for all measurements in both groups were better than pre-treatment levels(P < 0.05). The post-treatment levels for all measurements in the treatment group were better than the levels measured in the control group(P < 0.05).CONCLUSION: Type 2 diabetes mellitus and vascular dementia have common pathological mechanisms for insulin resistance and endothelium dysfunction. Sancaijiangtang powders could improve the release of nitric oxide and inhibit the secretion of endothelin-1. Therefore,the material basis exists for treating the different diseases with the same method in Traditional Chinese Medicine.
文摘In this paper, the author analyses the wooden drum dance from thesacrificial activity of Miao Slanghtering cattle to "eat gu zang" by the princi-ple and method of "dance ecology", On the other hand, he expounds the im-pact of modern culture on the dance.
基金Jointly supported by the National Important Basic Research Program of China(Grant No.2003CB214607)Program for Changjiang Scholars and Innovative Research Team in University(Grant No.IRT0559)the National Natural Science Foundation of China(Grant No.40372096)
文摘That more than 82 percent of proved sandstone-type uranium deposits coexist with proved oil-gas or coalfields in the world reflects the fact of coexistence and accumulation of multi-energy minerals including oil,gas,coal and uranium in the same basin.Especially,this phenomenon is most typical in the Central-east Asia energy basins.Across China,Mongolia and some central Asian countries,the giant Central-east Asia metallogenetic domain(CEAMD)stretches more than 6,000 km from Songliao Basin of China in the east to the Caspian Sea in the west.The multi-energy minerals distribution characteristics of the domain include:their spatial distribution is complicated and ordered;the ore-bearing horizon relates closely to the geographical region;the accumulation/mineralization and localization time is the same or close;the occurrence setting and accumulation/mineralization have close correlation;and they have rich provenance for all the minerals.All of these imply that they have close relations between each other under a unified geodynamic background.The exogenetic uranium mineralization process in CEAMD can be divided into five phases using time limits of 100 Ma,(50±2)Ma,20±(2―4)Ma,8―5 Ma.The major mineralization periods and their differences in each primary uranium-bearing basin are identical to the oil-gas accumulation and localization periods and phases in the same basin,and are also in response to regional tectonics and controlled in general by the regional geodynamic environment.For industrial application and commercial exploitation,it is suggested that an important period for coexistence,accumulation and localization of oil,gas,coal and uranium and their interaction mainly occur in the late/last and post basin evolution.Through generalized analysis and comparison of accumulation/mineralization environment of the energy basins in CEAMD,the authors propose that the relatively stable regional tectonic background and moderate(weaker)structural deformation probably are necessary for formation,coexistence and preservat
基金The project supported by the Key Project5 of National Natural Science Foundation of China under Grant No 70431002, and National Natural Science Foundation of China under Grant Nos. 70371068 and 10247005
文摘Based on the model of the same degree of all nodes we proposed before, a new algorithm, the so-called “spread all over vertices” （SAV） algorithm, is proposed for generating small-world properties from a regular ring lattices. During randomly rewiring connections the SAV is used to keep the unchanged number of links. Comparing the SAV algorithm with the Watts-Strogatz model and the “spread all over boundaries” algorithm, three methods can have the same topological properties of the small world networks. These results offer diverse formation of small world networks. It is helpful to the research of some applications for dynamics of mutual oscillator inside nodes and interacting automata associated with networks.
基金financially supported by the National Key Research and Development Program of China (2018YFC1706300 and 2018YFC17063005)the Fundamental Research Funds for the Central Universities (lzujbky-2019-92, lzujbky-2020-sp13)+2 种基金the Project for Longyuan Youth Innovation and Entrepreneurship TalentScience the Special funds for Innovation and Guidance of Gansu (2017ZX-02)the Science-Technology Plan Project from Lanzhou Science and Technology Bureau (2017-RC115)。
文摘Objective: "Same treatment for different diseases" is a unique treatment strategy under the guidance of traditional Chinese medicine(TCM) theory.Codonopsis Radix(Codonopsis pilosula,Dangshen in Chinese)with spleen-fortifying effect was employed to understand the strategy of "Same treatment for different diseases",based on its common mechanism in the treatment of gastric diseases including gastric ulcer,gastritis and gastric cancer via network pharmacology research.Methods:Network pharmacology research methods were used to analyze the interaction network and potential mechanisms of Dangshen in treating gastric ulcer,gastritis and gastric cancer.The active components and their target proteins of Dangshen were integrated from TCMSP,BATMAN-TCM databases.The targets of gastric ulcer,gastritis and gastric cancer were collected through GeneCards,PubMed,TDD and DisGeNET Database.Through screening,the key components and the key targets of Dangshen in treating gastric ulcer,gastritis and gastric cancer were obtained.After KEGG pathway analysis and GO analysis,the important pathways and biological processes were analyzed.Results:Through data and literature mining,the common and specific pharmaceutical effects and mechanism of Dangshen were summarized in these three gastric lesions.It was shown that Dangshen mainly acted on gastric ulcer,gastritis and gastric cancer through the overall regulation of the PI3K-AkT signaling pathway.With the development of the disease,it will gradually increase the control of inflammation through TNF,NF-κB and other inflammation-related signaling pathways to reduce inflammatory damage.For tumorigenesis,it pays more attention to inhibiting the ErbB signaling pathways to reduce the proliferation and migration of tumor cells.In addition,Dangshen's regulation of HIF-1 signaling pathway may also be beneficial for the treatment of gastric ulcer,gastritis and gastric cancer.Conclusion:Dangshen achieves spleen-fortifying effect on gastric diseases including gastric ulcer,gastritis and gastric cancer t
基金Supported by the National Natural Science Foundation of China(No.81573845,81473367,81403209,30825047)China Academy of Chinese Medical Sciences Project(No.Z0412)Beijing Nova Program(No.xx2014B073)
文摘Objective： To identify the commonalities between rheumatoid arthritis （RA） and diabetes mellitus （DM） to understand the mechanisms of Chinese medicine （CM） in different diseases with the same treatment. Methods： A text mining approach was adopted to analyze the commonalities between RA and DM according to CM and biological elements. The major commonalities were subsequently verified in RA and DM rat models, in which herbal formula for the treatment of both RA and DM identified via text mining was used as the intervention. Results： Similarities were identified between RA and DM regarding the CM approach used for diagnosis and treatment, as well as the networks of biological activities affected by each disease, including the involvement of adhesion molecules, oxidative stress, cytokines, T-lymphocytes, apoptosis, and inflammation. The Ramulus Cinnamomi-Radix Paeoniae Alba-Rhizoma Anemarrhenae is an herbal combination used to treat RA and DM. This formula demonstrated similar effects on oxidative stress and inflammation in rats with collagen-induced arthritis, which supports the text mining results regarding the commonalities between RA and DM. Conclusion： Commonalities between the biological activities involved in RA and DM were identified through text mining, and both RA and DM might be responsive to the same intervention at a specific stage.
