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基于“肾脑相关”研究熟地黄对ADHD模型SHR大鼠前额叶、纹状体BDNF/TrkB及NRG-3的调控作用 被引量:20
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作者 袁海霞 倪新强 +4 位作者 吴正治 韩新民 胥丹桂 宋宇尘 陈天翼 《中国中药杂志》 CAS CSCD 北大核心 2018年第17期3539-3544,共6页
研究熟地黄对注意缺陷多动障碍(ADHD)大鼠行为学及前额叶、纹状体组织中脑源性神经营养因子(BDNF)、酪氨酸蛋白激酶受体B(TrkB)以及神经调节蛋白-3(NRG-3)的影响.将30只4周龄SHR大鼠随机分为模型组、盐酸哌甲酯(MPH)组(2 mg·kg-1 &... 研究熟地黄对注意缺陷多动障碍(ADHD)大鼠行为学及前额叶、纹状体组织中脑源性神经营养因子(BDNF)、酪氨酸蛋白激酶受体B(TrkB)以及神经调节蛋白-3(NRG-3)的影响.将30只4周龄SHR大鼠随机分为模型组、盐酸哌甲酯(MPH)组(2 mg·kg-1 ·d-1)、熟地黄组(2.4g·kg-1·d-1),另设WKY大鼠为正常组,每组10只.正常组与模型组均予相应体积的0.5% CMC-Na溶液.在给药前、给药2周、给药4周时分别进行开场实验以评估大鼠自发性行为.RT-qPCR,West-ern blot法检测各组大鼠前额叶及纹状体中BDNF,TrkB,NRG-3 mRNA及蛋白表达水平.开场实验结果显示,给药4周时,与模型组相比,MPH组及熟地黄组总运动距离、平均速度、中心区域运动距离均显著降低(p<0.05),且熟地黄组中心区域运动距离显著低于MPH组(P<0.05).RT-qPCR,Western blot结果显示,给药前模型组大鼠前额叶、纹状体中BDNF,TrkB,NRG-3 mR-NA和蛋白表达水平均明显低于正常组(P<0.05);给药4周后,与模型组比较,MPH组及熟地黄组前额叶、纹状体中上述mRNA和蛋白表达水平均显著提高(P<0.05).结果表明BDNF,TrkB,NRG-3介导的神经元发育障碍与SHR大鼠的行为表现密切相关,熟地黄可能通过增加BDNF,TrkB,NRG-3的表达来促进神经元生长、发育、成熟,从而起到控制ADHD多动、冲动的作用. 展开更多
关键词 熟地黄 注意缺陷多动障碍 脑源性神经营养因子 酪氨酸激酶受体B 神经调节蛋白-3 自发性高血压大鼠
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Si-Al-Ir Oxidation Resistant Coating for Carbon/Carbon Composites by Slurry Dipping 被引量:2
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作者 Min Huang Kezhi Li +2 位作者 Hejun Li Qiangang Fu Yu Wang 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2009年第3期344-346,共3页
A Si-Al-lr oxidation resistant coating was prepared for SiC coated carbon/carbon composites by slurry dipping. The phase composition, microstructure and oxidation resistance of the as-prepared Si-Al-lr coating were st... A Si-Al-lr oxidation resistant coating was prepared for SiC coated carbon/carbon composites by slurry dipping. The phase composition, microstructure and oxidation resistance of the as-prepared Si-Al-lr coating were studied by XRD (X-ray diffraction), SEM (scanning electron microscopy), and isothermal oxidation test at 1773 K in air, respectively. The surface of the as-prepared Si-Al-lr coating was dense and the thickness was approximately 100 um. Its anti-oxidation property was superior to that of the inner SiC coating. The weight loss of SiC/Si- Al-lr coated carbon/carbon composites was less than 5 wt. pct after oxidation at 1773 K in air for 79 h. The local oxidation defects in the coating may result in the failure of the SiC/Si-Al-Ir coating. 展开更多
关键词 Carbon/carbon composites COATINGS OXIDATION si-Al-ir
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