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青蒿素和槲皮素抑制新冠病毒刺突蛋白介导的细胞因子风暴 被引量:1
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作者 吴伟 吴俊汐 +3 位作者 纪旭旭 刘戟 刘彬 耿福昌 《云南中医药大学学报》 2023年第4期16-24,共9页
目的研究青蒿素和槲皮素的单独或联合治疗是否能改善新冠病毒(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)的棘突蛋白(spike protein,S蛋白)介导的细胞因子风暴。方法进行细胞活力测定,而后检测青蒿素或槲皮素单独或... 目的研究青蒿素和槲皮素的单独或联合治疗是否能改善新冠病毒(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)的棘突蛋白(spike protein,S蛋白)介导的细胞因子风暴。方法进行细胞活力测定,而后检测青蒿素或槲皮素单独或联合处理对SARS-CoV-2的S蛋白介导的细胞因子风暴的改善作用。结果在SARS-CoV-2 S蛋白刺激下,青蒿素或槲皮素的单独或联合治疗可以通过抑制NFKB的过度激活来显著减轻细胞因子风暴。结论单独和联合使用青蒿素和槲皮素均能有效地抑制SARS-CoV-2 S蛋白介导的细胞因子风暴。 展开更多
关键词 青蒿素 槲皮素 sas-cov-2 刺突蛋白 细胞因子风暴 彝族药物
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通过通风系统感染新冠病毒的风险评估模型 被引量:3
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作者 王昕 杨敏 +2 位作者 卜震 张倩茹 孙志成 《暖通空调》 2022年第2期108-112,40,共6页
为评估在通风系统中可能出现的危险事件对室内病毒浓度或室内人群感染病毒概率的影响,根据新冠病毒传播机理,基于空气传染病概率模型和风险矩阵法,提出了通过通风系统感染新冠病毒的风险评估模型,该模型包含对病毒传播有重要影响的危险... 为评估在通风系统中可能出现的危险事件对室内病毒浓度或室内人群感染病毒概率的影响,根据新冠病毒传播机理,基于空气传染病概率模型和风险矩阵法,提出了通过通风系统感染新冠病毒的风险评估模型,该模型包含对病毒传播有重要影响的危险事件发生概率、新风量、呼吸通风量、暴露时间等主要参数。以室内人群感染病毒概率作为后果的量化指标进行算例分析,结果表明,室内人群感染病毒概率受危险事件发生概率和其后果严重程度共同影响,危险事件发生可能性和对通风系统中关键参数新风量和消杀效率的影响越大,易感人群的平均感染概率越大。 展开更多
关键词 通风系统 新冠病毒 风险评估模型 感染概率 风险因子 新风量 消杀效率 病毒浓度
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Practical Mitigation Strategies for Countering the Spread of Aerosolized COVID-19 Virus (SARS-CoV-2) Using Ventilation and HEPA Air Purifiers: A Literature Review 被引量:1
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作者 Panayiotis Polyzois Shirley Thompson 《Journal of Geoscience and Environment Protection》 2021年第9期166-197,共32页
This paper assesses, through an extensive literature review, the use of ventilation and High-Efficiency Particulate Air (HEPA) purifiers as practical mitigation strategies for reducing the spread of aerosolized COVID-... This paper assesses, through an extensive literature review, the use of ventilation and High-Efficiency Particulate Air (HEPA) purifiers as practical mitigation strategies for reducing the spread of aerosolized COVID-19<sup>1</sup> virus. HEPA is a well-defined standard by the U.S. Department of Energy for filters. The focus of the literature review was on indoor air quality (IAQ) and COVID-19, with a particular emphasis on classroom settings. The start of the review, January 2020, was chosen to coincide with the first cases of COVID-19 in North America. Although children under the age of 12 are currently not yet vaccinated, there is mounting pressure for a return to normal by the start of the new school year, 2021. Also, many classrooms lack pre-installed mechanical ventilation systems (<a href="#ref79">Olsiewski et al., 2021</a>);therefore, mitigation in classrooms often falls solely in the hands of teachers and students. Research shows that ventilation and air purification are essential tools to counter aerosolized transmission (<5 μm) of the COVID-19 virus. According to <a href="#ref25">Curtius et al. (2020)</a>, the inhaled dose of particles containing virus RNA is six times lower when using air purifiers with an ACH (air changes per hour) of 5.7. However, ventilation and air purifiers are not replacements for masks, which remain vital for countering droplet (>5 μm) transmission. In addition, occupancy (i.e., number and proximity of people present in a given area) and group activity levels (e.g., talking, shouting, singing) play a critical role in viral transmission. Although natural ventilation by opening windows can be an essential strategy to help counter the spread of the virus, the level of ventilation offered by opening windows is largely uncontrollable as it is subject to weather <span style="font-family:Verdana;">conditions and building design. One must also consider the energy implications (i.e., loss of heat) that this strategy carries. Scientific evidence shows that varying levels of continuous 展开更多
关键词 covID-19 sas-cov-2 Aerosolized Ventilation HEPA Air Purifier(s)
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