Background Anxiety symptoms are common in mental diseases and a variety of physical disorders, especially in disorders related to stress. More and more basic studies have indicated that gut microbiota can regulate bra...Background Anxiety symptoms are common in mental diseases and a variety of physical disorders, especially in disorders related to stress. More and more basic studies have indicated that gut microbiota can regulate brain function through the gut-brain axis, and dysbiosis of intestinal microbiota was related to anxiety. However, there is no specific evidence to support treatment of anxiety by regulating intestinal microbiota. Aims To find evidence sup porting improvement of anxiety symptoms by regulation of intestinal microbiota. Methods This systematic review of randomised controlled trials was searched based on the following databases: PubMed, EMBASE, the Cochrane Library, OVID, Web of Knowledge, China National Knowledge Infrastructure (CNKI), Wanfang Data, VIP databases and SinoMed. The retrieval time dated back to 25 July 2018. Then we screened research literatures based on established inclusion and exclusion criteria. Quality evaluation for each included study was done using the Cochrane risk of bias and the Jadad scale. Results A total of 3334 articles were retrieved and 21 studies were included which contained 1503 subjects. In the 21 studies, 15 chose probiotics as interventions to regulate intestinal microbiota and six chose non-probiotic ways such as adjusting daily diets. Probiotic supplements in seven studies contained only one kind of probiotic, two studies used a product that contained two kinds of probiotics and the supplements used in the other five studies included at least three kinds of probiotics. In the studies that used treatment as usual plus interventions regulating intestinal flora (IRIF) as interventions (five studies), only non-probiotic ways were effective (two studies), which means 40% of studies were effective;in the studies that used IRIF alone (16 studies, 11 studies used probiotic ways and 5 studies used non-probiotic ways), 56% of studies could improve anxiety symptoms, and 80% of studies that conducted the non-probiotic interventions were effective, while 45% of studies that used 展开更多
In order to find the roles of knowledge-intensive business services （KIBS） in the innovation activities, This paper focus on three perspectives. First, we find that KIBS possess good prerequisites to function as veh...In order to find the roles of knowledge-intensive business services （KIBS） in the innovation activities, This paper focus on three perspectives. First, we find that KIBS possess good prerequisites to function as vehicles in innovation distribution, the sources of innovation and the facilitators of innovation in their client firms. Second, we further discuss KIBS as the knowledge and innovation infrastructure of society in parallel with the research, educational and other public institutions. Third, we present some research policies and agenda to promote the development of KIBS. It is regarded that much remains to be studied both in the use of KIBS and in their own activities, including integrating and networking the knowledge-intensive services into the client companies, the convergence of various services and closer connection with the client companies＇ strategy, and the national policies to connect the KIBS to the different sectors.展开更多
The paper aims at providing a computerized design environment to support product design practically. The authors solved this problem by taking the product life-cycle issues into consideration as more as possible durin...The paper aims at providing a computerized design environment to support product design practically. The authors solved this problem by taking the product life-cycle issues into consideration as more as possible during the design process from the designer-oriented perspective of view. Design for X-abilities (DFX) is an effective approach to this philosophy. So the paper mainly presents the infrastructure of an intelligent DFX mechanism which is the essential part of the developed product design environment. At first the designer-oriented computer environment DesignerSpace is introduced for understanding the designer how to implement design activities and DFX method better. In order to integrate design knowledge from downstream aspects for the optimization and the design decision-making, an intelligent DFX mechanism is developed to incorporate knowledge base, algorithm-base and monitoring/debugging tools. DesignerSpace is implemented with DFX abilities and applied to the blisk design of aircraft engine and the further development is strongly intended.展开更多
This paper examines the current state of three of the key areas of geospatial science in Australia:positioning;earth observation(EO);and spatial infrastructures.The paper discusses the limitations and challenges that ...This paper examines the current state of three of the key areas of geospatial science in Australia:positioning;earth observation(EO);and spatial infrastructures.The paper discusses the limitations and challenges that will shape the development of these three areas of geospatial science over the next decade and then profiles what each may look like in about 2026.Australia’s national positioning infrastructure plan is guiding the development of a nation-wide,sub decimeter,real-time,outdoor positioning capability based on multi-GNSS and in particular the emerging precise point positioning−real-time kinematic(PPP-RTK)capability.Additional positioning systems including the ground-based Locata system,location-based indoor systems,and beacons,among others are also discussed.The importance of the underpinning role of a next generation dynamic datum is considered.The development of Australia’s first EO strategy is described along with the key national needs of the products of remote sensing.The development of massive on-line multi-decadal geospatial imagery data stores and processing engines for co-registered stacks of continuous base-line satellite imagery are explored.Finally,perspectives on the evolution of a future spatial knowledge infrastructure(SKI)emerging from today’s traditional spatial data infrastructures(SDIs)are provided together with discussion of the growing importance of geospatial analytics for transforming whole supply chains.展开更多
基金National Natural Science Foundation of China (81571326,81501153)National Key R&D Program of China (2017YFC0909200).
文摘Background Anxiety symptoms are common in mental diseases and a variety of physical disorders, especially in disorders related to stress. More and more basic studies have indicated that gut microbiota can regulate brain function through the gut-brain axis, and dysbiosis of intestinal microbiota was related to anxiety. However, there is no specific evidence to support treatment of anxiety by regulating intestinal microbiota. Aims To find evidence sup porting improvement of anxiety symptoms by regulation of intestinal microbiota. Methods This systematic review of randomised controlled trials was searched based on the following databases: PubMed, EMBASE, the Cochrane Library, OVID, Web of Knowledge, China National Knowledge Infrastructure (CNKI), Wanfang Data, VIP databases and SinoMed. The retrieval time dated back to 25 July 2018. Then we screened research literatures based on established inclusion and exclusion criteria. Quality evaluation for each included study was done using the Cochrane risk of bias and the Jadad scale. Results A total of 3334 articles were retrieved and 21 studies were included which contained 1503 subjects. In the 21 studies, 15 chose probiotics as interventions to regulate intestinal microbiota and six chose non-probiotic ways such as adjusting daily diets. Probiotic supplements in seven studies contained only one kind of probiotic, two studies used a product that contained two kinds of probiotics and the supplements used in the other five studies included at least three kinds of probiotics. In the studies that used treatment as usual plus interventions regulating intestinal flora (IRIF) as interventions (five studies), only non-probiotic ways were effective (two studies), which means 40% of studies were effective;in the studies that used IRIF alone (16 studies, 11 studies used probiotic ways and 5 studies used non-probiotic ways), 56% of studies could improve anxiety symptoms, and 80% of studies that conducted the non-probiotic interventions were effective, while 45% of studies that used
文摘In order to find the roles of knowledge-intensive business services （KIBS） in the innovation activities, This paper focus on three perspectives. First, we find that KIBS possess good prerequisites to function as vehicles in innovation distribution, the sources of innovation and the facilitators of innovation in their client firms. Second, we further discuss KIBS as the knowledge and innovation infrastructure of society in parallel with the research, educational and other public institutions. Third, we present some research policies and agenda to promote the development of KIBS. It is regarded that much remains to be studied both in the use of KIBS and in their own activities, including integrating and networking the knowledge-intensive services into the client companies, the convergence of various services and closer connection with the client companies＇ strategy, and the national policies to connect the KIBS to the different sectors.
文摘The paper aims at providing a computerized design environment to support product design practically. The authors solved this problem by taking the product life-cycle issues into consideration as more as possible during the design process from the designer-oriented perspective of view. Design for X-abilities (DFX) is an effective approach to this philosophy. So the paper mainly presents the infrastructure of an intelligent DFX mechanism which is the essential part of the developed product design environment. At first the designer-oriented computer environment DesignerSpace is introduced for understanding the designer how to implement design activities and DFX method better. In order to integrate design knowledge from downstream aspects for the optimization and the design decision-making, an intelligent DFX mechanism is developed to incorporate knowledge base, algorithm-base and monitoring/debugging tools. DesignerSpace is implemented with DFX abilities and applied to the blisk design of aircraft engine and the further development is strongly intended.
文摘This paper examines the current state of three of the key areas of geospatial science in Australia:positioning;earth observation(EO);and spatial infrastructures.The paper discusses the limitations and challenges that will shape the development of these three areas of geospatial science over the next decade and then profiles what each may look like in about 2026.Australia’s national positioning infrastructure plan is guiding the development of a nation-wide,sub decimeter,real-time,outdoor positioning capability based on multi-GNSS and in particular the emerging precise point positioning−real-time kinematic(PPP-RTK)capability.Additional positioning systems including the ground-based Locata system,location-based indoor systems,and beacons,among others are also discussed.The importance of the underpinning role of a next generation dynamic datum is considered.The development of Australia’s first EO strategy is described along with the key national needs of the products of remote sensing.The development of massive on-line multi-decadal geospatial imagery data stores and processing engines for co-registered stacks of continuous base-line satellite imagery are explored.Finally,perspectives on the evolution of a future spatial knowledge infrastructure(SKI)emerging from today’s traditional spatial data infrastructures(SDIs)are provided together with discussion of the growing importance of geospatial analytics for transforming whole supply chains.
