AIM To provide a quantitative assessment of theassociation between type 2 diabetes mellitus （T2DM）and the risk of colorectal cancer （CRC）.METHODS： Systematic review was conductedthorough MEDLINE, EMBASE, Cochrane...AIM To provide a quantitative assessment of theassociation between type 2 diabetes mellitus （T2DM）and the risk of colorectal cancer （CRC）.METHODS： Systematic review was conductedthorough MEDLINE, EMBASE, Cochrane Library, and ISI Web of knowledge databases till 31st January 2014.This meta-analysis included the cohort studies thatillustrated relative risk （RR） or odds ratio estimateswith 95%CI for the predictive risk of CRC by T2DM.Summary relative risks with 95%CI were analyzed byusing an effects summary ratio model. Heterogeneityamong studies was assessed by the Cochran＇s Q and I 2statistics.RESULTS： The meta analysis of 8 finally selectedstudies showed a positive correlation of T2DM withthe risk of CRC as depicted by effects summary RRof 1.21 （95%CI： 1.02-1.42）. Diabetic women showedgreater risk of developing CRC as their effect summaryRR of 1.22 （95%CI： 1.01-49） with significant overallZ test at 5% level of significance was higher than theeffect summary RR of 1.17 （95%CI： 1.00-1.37） of menshowing insignificant Z test. The effect summary RRof 1.19 with 95%CI of 1.07-1.33 indicate a positiverelationship between DM and increased risk of CRCwith significant heterogeneity （I 2 = 92% and P -value 〈0.05）.CONCLUSION： Results from this systematic reviewand meta-analysis report that diabetic people have anincreased risk of CRC as compared to non-diabetics.展开更多
文摘AIM To provide a quantitative assessment of theassociation between type 2 diabetes mellitus （T2DM）and the risk of colorectal cancer （CRC）.METHODS： Systematic review was conductedthorough MEDLINE, EMBASE, Cochrane Library, and ISI Web of knowledge databases till 31st January 2014.This meta-analysis included the cohort studies thatillustrated relative risk （RR） or odds ratio estimateswith 95%CI for the predictive risk of CRC by T2DM.Summary relative risks with 95%CI were analyzed byusing an effects summary ratio model. Heterogeneityamong studies was assessed by the Cochran＇s Q and I 2statistics.RESULTS： The meta analysis of 8 finally selectedstudies showed a positive correlation of T2DM withthe risk of CRC as depicted by effects summary RRof 1.21 （95%CI： 1.02-1.42）. Diabetic women showedgreater risk of developing CRC as their effect summaryRR of 1.22 （95%CI： 1.01-49） with significant overallZ test at 5% level of significance was higher than theeffect summary RR of 1.17 （95%CI： 1.00-1.37） of menshowing insignificant Z test. The effect summary RRof 1.19 with 95%CI of 1.07-1.33 indicate a positiverelationship between DM and increased risk of CRCwith significant heterogeneity （I 2 = 92% and P -value 〈0.05）.CONCLUSION： Results from this systematic reviewand meta-analysis report that diabetic people have anincreased risk of CRC as compared to non-diabetics.
