Technological advancements are continuously changing the paradigm of human existence.Human beings are constantly engaging in various measures to reduce the extent of sensory and motor impairment.This has been in the f...Technological advancements are continuously changing the paradigm of human existence.Human beings are constantly engaging in various measures to reduce the extent of sensory and motor impairment.This has been in the form of various devices,e.g.orthopedic prosthesis,visual aids (spectacles) and hearing aids.Countless attempts throughout the centuries have been made in an effort to improve sound amplification in patients.This article seeks to highlights the technological journey of one such implant,the middle ear implant,from its inception to the more technological advanced futuristic proposals.While there are many amplification devices available presently,there still remains a group of patients who have not experienced adequate amplification for their hearing loss and this subset may gain the greatest benefit from middle ear implants.展开更多
Purpose:To observe the clinical and imaging characteristics of radiation-induced optic neuropathy(RION).Methods:We retrospectively reviewed the clinical data of 43 patients(69 eyes)who were diagnosed with RION at the ...Purpose:To observe the clinical and imaging characteristics of radiation-induced optic neuropathy(RION).Methods:We retrospectively reviewed the clinical data of 43 patients(69 eyes)who were diagnosed with RION at the Chinese PLA General Hospital from 2010 to 2021.Results:The latency from radiotherapy to onset of visual loss ranged from 1 to 132(36.33±30.48)months.Optic disc pallor and optic disc edema were found in 27.0%(10/37)and 8.1%(3/37)of the eyes,respectively,within 2 months.After treatment,the best corrected visual acuity(BCVA)was restored in 24.6%(17/69)of the eyes and the final BCVA improved in 13.0%(9/69)of the eyes.An 82.5%(33/40)of the eyes with magnetic resonance imaging(MRI)showed enhancement of the affected optic nerve,mostly(69.7%)in the intracranial segment,and 36.4%(12/33)of the eyes with expansion and T2-high signals also showed enhancement of the affected optic nerve.The superior retinal nerve fiber layer(RNFL)and the outer circle superior quadrant(OS)of the inner limiting membrane to retinal pigment epithelium(ILM-RPE)layer thinned significantly during the first month.The center of the ILM-RPE layer thickened significantly during the first two months and the inner circle temporal quadrant(IT)of the ILM-RPE layer thickened significantly from the third to sixth month.The RNFL thinned significantly after 6 months except for the temporal quadrant,and the average inner circle superior quadrant(IS)and outer circle of the ILM-RPE layer thinned significantly after 6 months.There was no significant difference between hyperbaric oxygen therapy(HBOT)and high-dose intravenous methylprednisolone(IVMP)therapy in improving BCVA recovery or final BCVA(P>0.05).Conclusions:The structural damage of the RNFL and ILM-RPE layer occurred during the first month,the RNFL showed progressive thinning during the follow-up period,while the ILM-RPE layer showed thinning during the first month,thickening from the third to sixth month,and thinning after 6 months.There was a discrete region of enhancement of the optic nerve展开更多
针对软测量方法实际应用中查询样本可能出现奇异点这一问题,提出一种带奇异点检测和补偿的高斯过程回归(Gaussian process regression,GPR)在线软测量方法。该方法首先对训练样本利用高斯过程回归方法进行建模,得到软测量模型;然后对新...针对软测量方法实际应用中查询样本可能出现奇异点这一问题,提出一种带奇异点检测和补偿的高斯过程回归(Gaussian process regression,GPR)在线软测量方法。该方法首先对训练样本利用高斯过程回归方法进行建模,得到软测量模型;然后对新来查询样本采用改进拉依达准则进行奇异点检测,当新来查询样本被确定为奇异点时,利用辅助模型进行修补,然后再利用软测量模型对修补后查询样本点进行预测;否则,直接对新来查询样本点使用软测量模型进行预测,此方法能够有效确保新来查询样本点的有效性。通过对实际硫回收过程的数据进行实验仿真,进一步验证了所提方法的有效性。展开更多
To exploit the effect of modulation schemes on the best relay selection,a novel Jointing Modulation schemes max-min criterion(JM-max-min) is proposed firstly for Two-Way De-Noise-and-Forward(DNF) Opportunistic Relayin...To exploit the effect of modulation schemes on the best relay selection,a novel Jointing Modulation schemes max-min criterion(JM-max-min) is proposed firstly for Two-Way De-Noise-and-Forward(DNF) Opportunistic Relaying systems(TW-DNF-OR) by aiming at minimizing the Pairwise Error Probability(PEP) of Multi-Access(MA) phase which dominates the error per-formance of TW-DNF-OR due to the presence of MA interference.The proposed JM-max-min criterion integrates perfectly the minimum distances of constellations and the relay links gains.Then,with the proposed JM-max-min criterion,we analyze the Symbol Error Probabilities(SEPs) of MA phase and BroadCast(BC) phase by using the approximated mathematics analysis,and present the corresponding closed-form expressions to SEPs.The numerical analysis shows,for a given modulations combination at both sources,the TW-DNF-OR systems with the proposed JM-max-min criterion outperform the one with the conventional max-min criterion.展开更多
The nucleocapsid of vesicular stomatitis virus serves as the genomic template for transcription and replication. The viral genomic RNA is sequestered in the nucleocapsid in every step of the virus replication cycle. T...The nucleocapsid of vesicular stomatitis virus serves as the genomic template for transcription and replication. The viral genomic RNA is sequestered in the nucleocapsid in every step of the virus replication cycle. The structure of the nucleocapsid and the entire virion revealed how the viral genomic RNA is encapsidated and packaged in the virus. A unique mechanism for viral RNA synthesis is derived from the structure of the nuleocapsid and its interactions with the viral RNA-dependent RNA polymerase.展开更多
文摘Technological advancements are continuously changing the paradigm of human existence.Human beings are constantly engaging in various measures to reduce the extent of sensory and motor impairment.This has been in the form of various devices,e.g.orthopedic prosthesis,visual aids (spectacles) and hearing aids.Countless attempts throughout the centuries have been made in an effort to improve sound amplification in patients.This article seeks to highlights the technological journey of one such implant,the middle ear implant,from its inception to the more technological advanced futuristic proposals.While there are many amplification devices available presently,there still remains a group of patients who have not experienced adequate amplification for their hearing loss and this subset may gain the greatest benefit from middle ear implants.
基金supported by the National Key Research and Development Program. (Project code:2018YFE0113900 to S⋅W.)the National Natural Science Foundation of China (Project code:81870662 to S⋅W.)on the study.
文摘Purpose:To observe the clinical and imaging characteristics of radiation-induced optic neuropathy(RION).Methods:We retrospectively reviewed the clinical data of 43 patients(69 eyes)who were diagnosed with RION at the Chinese PLA General Hospital from 2010 to 2021.Results:The latency from radiotherapy to onset of visual loss ranged from 1 to 132(36.33±30.48)months.Optic disc pallor and optic disc edema were found in 27.0%(10/37)and 8.1%(3/37)of the eyes,respectively,within 2 months.After treatment,the best corrected visual acuity(BCVA)was restored in 24.6%(17/69)of the eyes and the final BCVA improved in 13.0%(9/69)of the eyes.An 82.5%(33/40)of the eyes with magnetic resonance imaging(MRI)showed enhancement of the affected optic nerve,mostly(69.7%)in the intracranial segment,and 36.4%(12/33)of the eyes with expansion and T2-high signals also showed enhancement of the affected optic nerve.The superior retinal nerve fiber layer(RNFL)and the outer circle superior quadrant(OS)of the inner limiting membrane to retinal pigment epithelium(ILM-RPE)layer thinned significantly during the first month.The center of the ILM-RPE layer thickened significantly during the first two months and the inner circle temporal quadrant(IT)of the ILM-RPE layer thickened significantly from the third to sixth month.The RNFL thinned significantly after 6 months except for the temporal quadrant,and the average inner circle superior quadrant(IS)and outer circle of the ILM-RPE layer thinned significantly after 6 months.There was no significant difference between hyperbaric oxygen therapy(HBOT)and high-dose intravenous methylprednisolone(IVMP)therapy in improving BCVA recovery or final BCVA(P>0.05).Conclusions:The structural damage of the RNFL and ILM-RPE layer occurred during the first month,the RNFL showed progressive thinning during the follow-up period,while the ILM-RPE layer showed thinning during the first month,thickening from the third to sixth month,and thinning after 6 months.There was a discrete region of enhancement of the optic nerve
文摘针对软测量方法实际应用中查询样本可能出现奇异点这一问题,提出一种带奇异点检测和补偿的高斯过程回归(Gaussian process regression,GPR)在线软测量方法。该方法首先对训练样本利用高斯过程回归方法进行建模,得到软测量模型;然后对新来查询样本采用改进拉依达准则进行奇异点检测,当新来查询样本被确定为奇异点时,利用辅助模型进行修补,然后再利用软测量模型对修补后查询样本点进行预测;否则,直接对新来查询样本点使用软测量模型进行预测,此方法能够有效确保新来查询样本点的有效性。通过对实际硫回收过程的数据进行实验仿真,进一步验证了所提方法的有效性。
基金Supported by the National Natural Science Foundations of China (No. 61071090,No. 61171093)the Postgraduate Innovation Programs of Scientific Research of Jiangsu Province (CX10B-184Z,CXZZ11_0388)the Project 11KJA510001 and PAPD
文摘To exploit the effect of modulation schemes on the best relay selection,a novel Jointing Modulation schemes max-min criterion(JM-max-min) is proposed firstly for Two-Way De-Noise-and-Forward(DNF) Opportunistic Relaying systems(TW-DNF-OR) by aiming at minimizing the Pairwise Error Probability(PEP) of Multi-Access(MA) phase which dominates the error per-formance of TW-DNF-OR due to the presence of MA interference.The proposed JM-max-min criterion integrates perfectly the minimum distances of constellations and the relay links gains.Then,with the proposed JM-max-min criterion,we analyze the Symbol Error Probabilities(SEPs) of MA phase and BroadCast(BC) phase by using the approximated mathematics analysis,and present the corresponding closed-form expressions to SEPs.The numerical analysis shows,for a given modulations combination at both sources,the TW-DNF-OR systems with the proposed JM-max-min criterion outperform the one with the conventional max-min criterion.
基金supported by the National Institutes of Health (Grant No. AI050066)
文摘The nucleocapsid of vesicular stomatitis virus serves as the genomic template for transcription and replication. The viral genomic RNA is sequestered in the nucleocapsid in every step of the virus replication cycle. The structure of the nucleocapsid and the entire virion revealed how the viral genomic RNA is encapsidated and packaged in the virus. A unique mechanism for viral RNA synthesis is derived from the structure of the nuleocapsid and its interactions with the viral RNA-dependent RNA polymerase.
