AIM： To describe retinal findings of various imaging modalities in acute retinal ischemia. METHODS： Fluorescein angiography（FA）, spectral domain optical coherence tomography（SD-OCT）, OCTangiography（OCT-A） and ...AIM： To describe retinal findings of various imaging modalities in acute retinal ischemia. METHODS： Fluorescein angiography（FA）, spectral domain optical coherence tomography（SD-OCT）, OCTangiography（OCT-A） and fundus autofluorescence（FAF） images of 13 patients（mean age 64y, range 28-86y） with acute retinal ischemia were evaluated. Six suffered from branch arterial occlusion, 2 had a central retinal artery occlusion, 2 had a combined arteriovenous occlusions, 1 patient had a retrobulbar arterial compression by an orbital haemangioma and 2 patients showed an ocular ischemic syndrome.RESULTS： All patients showed increased reflectivity and thickening of the ischemic retinal tissue. In 10 out of 13 patients SD-OCT revealed an additional highly reflective band located within or above the outer plexiform layer. Morphological characteristics were a decreasing intensity with distance from the fovea, partially segmental occurrence and manifestation limited in time. OCT-A showed a loss of flow signal in the superficial and deep capillary plexus at the affected areas. Reduced flow signal was detected underneath the regions with retinal edema. FAF showed areas of altered signal intensity at the posterior pole. The regions of decreased FAF signal corresponded to peri-venous regions. CONCLUSION： Multimodal imaging modalities in retinal ischemia yield characteristic findings and valuable diagnostic information. Conventional OCT identifies hyperreflectivity and thickening and a mid-retinal hyperreflective band is frequently observed. OCT-A examination reveals demarcation of the ischemic retinal area on the vascular level. FAF shows decreased fluorescence signal in areas of retinal edema often corresponding to peri-venous regions.展开更多
In this study, rabbit models of optic nerve injury were reproduced by the clamp method. After modeling, rabbit models were given one injection of 50 ng recombinant human ciliary neurotrophic factor into the vitreous b...In this study, rabbit models of optic nerve injury were reproduced by the clamp method. After modeling, rabbit models were given one injection of 50 ng recombinant human ciliary neurotrophic factor into the vitreous body and/or intragastric injection of 4 g/kg compound light granules containing Radix Angelicae Sinensis and Raidix Paeoniae Alba at 4 days after modeling, once per day for 30 consecutive days. After administration, the animals were sacrificed and the intraorbital optic nerve was harvested. Hematoxylin-eosin staining revealed that the injured optic nerve was thinner and optic nerve fibers were irregular. After treatment with recombinant human ciliary neurotrophic factor, the arrangement of optic nerve fibers was disordered but they were not markedly thinner. After treatment with compound light granules, the arrangement of optic nerve fibers was slightly disordered and their structure was intact. After combined treatment with recombinant human ciliary neurotrophic factor and compound light granules, the arrangement of optic nerve fibers was slightly disordered and the degree of injury was less than after either treatment alone. Results of tensile mechanical testing of the optic nerve showed that the tensile elastic limit strain, elastic limit stress, maximum stress and maximum strain of the injured optic nerve were significantly lower than the normal optic nerve. After treatment with recombinant human ciliary neurotrophic factor and/or compound light granules, the tensile elastic limit strain, elastic limit stress, maximum stress and maximum strain of the injured optic nerve were significantly increased, especially after the combined treatment. These experimental findings indicate that compound light granules and ciliary neurotrophic factor can alleviate optic nerve injury at the histological and biochemical levels, and the combined treatment is more effective than either treatment alone.展开更多
目的定量描述北京市40岁及以上人群视网膜血管直径及其年龄、性别分布。设计横断面研究。研究对象"北京眼病研究"基线人群。方法采用定量测量软件(Singapore I Vessel Assessment,SIVA3.2)对3901例受检者随机一眼的彩色眼底...目的定量描述北京市40岁及以上人群视网膜血管直径及其年龄、性别分布。设计横断面研究。研究对象"北京眼病研究"基线人群。方法采用定量测量软件(Singapore I Vessel Assessment,SIVA3.2)对3901例受检者随机一眼的彩色眼底照片中距视盘边缘0.5~1 PD之间的环形区域(B区)以及距视盘边缘0.5~2 PD之间环形区域(C区)的视网膜血管直径进行测量。主要指标视网膜中央动脉当量(CRAE)、视网膜中央静脉当量(CRVE)、视网膜动静脉直径比(AVR)、视网膜动脉平均直径(MWa)、视网膜静脉平均直径(MWv)、视网膜动脉直径的标准偏差(STDWa)和视网膜静脉直径的标准偏差(STDWv)、视网膜动脉长度直径比(LDRa)和视网膜静脉长度直径比(LDRv)。结果 3901例40岁以上中老年人的B区平均CRAE、CRVE和AVR分别为(165.45±12.80)μm、(238.66±18.68)μm和0.70±0.06;C区平均CRAE、CRVE和AVR分别为(165.53±11.98)μm、(241.54±17.83)μm和0.69±0.05。不同年龄组间的CRAE和CRVE有明显差异,随年龄增长逐渐变小(P均<0.05),但各年龄组的AVR并无明显差异(P均>0.05)。男性的CRAE均比女性窄(P均<0.05),C区CRVE明显较宽(P=0.002),AVR均较小(P均=0.000)。C区MWa及STDWa分别为(89.83±6.55)μm和5.04±0.61,B区MWa及STDWa分别为(89.72±6.82)μm和4.93±0.61;C区MWv及STDWv分别为(102.31±8.23)μm和4.90±0.54,B区MWv及STDWv分别为(101.24±8.20)μm和4.89±0.58。各年龄组间MWa、MWv均无明显差异(P均>0.05),但各年龄组间STDWa和STDWv则差异明显(P均<0.05)。男性的MWa,以及C区的STDWa、STDWv均比女性窄(P均<0.05)。40岁以上中老年人的LDRa和LDRv分别为13.246±7.510和11.798±7.071,不同年龄、性别组间LDRa和LDRv均无明显差异(P均>0.05)。结论北京市40岁以上人群中,视网膜血管动静脉比约为0.69(接近于2:3),随年龄增长视网膜中央动静脉均逐渐变细,视网膜动静脉直径比、平均动静脉直径以及动静脉长度直径比均较稳定,但个体间展开更多
目的观察北京市40岁及以上中老年人视网膜血管直径的5年变化及其相关因素。设计队列研究。研究对象"北京眼病研究"5年随访人群中随机选取506人。方法采用定量测量软件(Singapore I Vessel Assessment,SIVA3.2)对506例受检者...目的观察北京市40岁及以上中老年人视网膜血管直径的5年变化及其相关因素。设计队列研究。研究对象"北京眼病研究"5年随访人群中随机选取506人。方法采用定量测量软件(Singapore I Vessel Assessment,SIVA3.2)对506例受检者随机一眼的彩色眼底照片中的视网膜血管直径进行测量。测量分区:距视盘边缘0.5～1 PD之间的环形区域为B区,距视盘边缘0.5～2 PD之间环形区域为C区。比较受检者基线与5年随访时各指标的变化情况,并分析其变化的相关因素。主要指标B区和C区的视网膜中央动脉当量(CRAE)、视网膜中央静脉当量(CRVE)、视网膜动静脉直径比(AVR)、视网膜动脉平均直径(MWa)、视网膜静脉平均直径(MWv)、视网膜动脉直径的标准偏差(STDWa)和视网膜静脉直径的标准偏差(STDWv)、视网膜动脉长度直径比(length–diameter ratio arteriole,LDRa)和视网膜静脉长度直径比(length–diameter ratio venule,LDRv)。结果 506例受检者中348例(68.9%)基线和5年随访时均获得了可评价的眼底照片。与基线时相比,5年后的B区CRAE、CRVE均无明显变化(P均>0.05);C区CRAE、CRVE均明显增大(P均=0.001);5年后的B区和C区AVR均无明显变化(P均>0.05)。5年后的视网膜B区和C区MWa、MWv均明显减小(P均=0.000);B区STDWa、STDWv明显增大(P均<0.05);C区STDWa、STDWv无明显变化(P均>0.05)。5年后的视网膜LDRa、LDRv均明显增加(P均=0.000)。多因素分析表明,MWa的变化与年龄相关(r=0.105,P=0.041);CRVE(r=5.733,P=0.029)、MWv(r=3.210,P=0.020)的变化与吸烟相关;STDWv的变化与高血脂相关(r=-0.204,P=0.023);LDRv的变化与冠心病相关(r=5.088,P=0.044)。结论 40岁以上中老年人5年后视网膜动静脉均逐渐变细,动静脉比值相对稳定。视网膜血管直径的变化与吸烟、高血脂、冠心病等全身因素相关。展开更多
文摘AIM： To describe retinal findings of various imaging modalities in acute retinal ischemia. METHODS： Fluorescein angiography（FA）, spectral domain optical coherence tomography（SD-OCT）, OCTangiography（OCT-A） and fundus autofluorescence（FAF） images of 13 patients（mean age 64y, range 28-86y） with acute retinal ischemia were evaluated. Six suffered from branch arterial occlusion, 2 had a central retinal artery occlusion, 2 had a combined arteriovenous occlusions, 1 patient had a retrobulbar arterial compression by an orbital haemangioma and 2 patients showed an ocular ischemic syndrome.RESULTS： All patients showed increased reflectivity and thickening of the ischemic retinal tissue. In 10 out of 13 patients SD-OCT revealed an additional highly reflective band located within or above the outer plexiform layer. Morphological characteristics were a decreasing intensity with distance from the fovea, partially segmental occurrence and manifestation limited in time. OCT-A showed a loss of flow signal in the superficial and deep capillary plexus at the affected areas. Reduced flow signal was detected underneath the regions with retinal edema. FAF showed areas of altered signal intensity at the posterior pole. The regions of decreased FAF signal corresponded to peri-venous regions. CONCLUSION： Multimodal imaging modalities in retinal ischemia yield characteristic findings and valuable diagnostic information. Conventional OCT identifies hyperreflectivity and thickening and a mid-retinal hyperreflective band is frequently observed. OCT-A examination reveals demarcation of the ischemic retinal area on the vascular level. FAF shows decreased fluorescence signal in areas of retinal edema often corresponding to peri-venous regions.
文摘In this study, rabbit models of optic nerve injury were reproduced by the clamp method. After modeling, rabbit models were given one injection of 50 ng recombinant human ciliary neurotrophic factor into the vitreous body and/or intragastric injection of 4 g/kg compound light granules containing Radix Angelicae Sinensis and Raidix Paeoniae Alba at 4 days after modeling, once per day for 30 consecutive days. After administration, the animals were sacrificed and the intraorbital optic nerve was harvested. Hematoxylin-eosin staining revealed that the injured optic nerve was thinner and optic nerve fibers were irregular. After treatment with recombinant human ciliary neurotrophic factor, the arrangement of optic nerve fibers was disordered but they were not markedly thinner. After treatment with compound light granules, the arrangement of optic nerve fibers was slightly disordered and their structure was intact. After combined treatment with recombinant human ciliary neurotrophic factor and compound light granules, the arrangement of optic nerve fibers was slightly disordered and the degree of injury was less than after either treatment alone. Results of tensile mechanical testing of the optic nerve showed that the tensile elastic limit strain, elastic limit stress, maximum stress and maximum strain of the injured optic nerve were significantly lower than the normal optic nerve. After treatment with recombinant human ciliary neurotrophic factor and/or compound light granules, the tensile elastic limit strain, elastic limit stress, maximum stress and maximum strain of the injured optic nerve were significantly increased, especially after the combined treatment. These experimental findings indicate that compound light granules and ciliary neurotrophic factor can alleviate optic nerve injury at the histological and biochemical levels, and the combined treatment is more effective than either treatment alone.
文摘目的观察北京市40岁及以上中老年人视网膜血管直径的5年变化及其相关因素。设计队列研究。研究对象"北京眼病研究"5年随访人群中随机选取506人。方法采用定量测量软件(Singapore I Vessel Assessment,SIVA3.2)对506例受检者随机一眼的彩色眼底照片中的视网膜血管直径进行测量。测量分区:距视盘边缘0.5～1 PD之间的环形区域为B区,距视盘边缘0.5～2 PD之间环形区域为C区。比较受检者基线与5年随访时各指标的变化情况,并分析其变化的相关因素。主要指标B区和C区的视网膜中央动脉当量(CRAE)、视网膜中央静脉当量(CRVE)、视网膜动静脉直径比(AVR)、视网膜动脉平均直径(MWa)、视网膜静脉平均直径(MWv)、视网膜动脉直径的标准偏差(STDWa)和视网膜静脉直径的标准偏差(STDWv)、视网膜动脉长度直径比(length–diameter ratio arteriole,LDRa)和视网膜静脉长度直径比(length–diameter ratio venule,LDRv)。结果 506例受检者中348例(68.9%)基线和5年随访时均获得了可评价的眼底照片。与基线时相比,5年后的B区CRAE、CRVE均无明显变化(P均>0.05);C区CRAE、CRVE均明显增大(P均=0.001);5年后的B区和C区AVR均无明显变化(P均>0.05)。5年后的视网膜B区和C区MWa、MWv均明显减小(P均=0.000);B区STDWa、STDWv明显增大(P均<0.05);C区STDWa、STDWv无明显变化(P均>0.05)。5年后的视网膜LDRa、LDRv均明显增加(P均=0.000)。多因素分析表明,MWa的变化与年龄相关(r=0.105,P=0.041);CRVE(r=5.733,P=0.029)、MWv(r=3.210,P=0.020)的变化与吸烟相关;STDWv的变化与高血脂相关(r=-0.204,P=0.023);LDRv的变化与冠心病相关(r=5.088,P=0.044)。结论 40岁以上中老年人5年后视网膜动静脉均逐渐变细,动静脉比值相对稳定。视网膜血管直径的变化与吸烟、高血脂、冠心病等全身因素相关。
