Retinal vein occlusion (RVO) is the most common visually disabling disease affecting the retina after diabetic retinopathy. Although the disease entity has long been known, its management is still controversial. Macul...Retinal vein occlusion (RVO) is the most common visually disabling disease affecting the retina after diabetic retinopathy. Although the disease entity has long been known, its management is still controversial. Macular edema is the main reason for decreased visual acuity (VA) in this retinal vascular disorder. Recently the vitreous cavity has increasingly been used as a reservoir of drugs for the direct treatment of macular edema through intravitreal injection route. The most widely injected drugs so far have been triamcinolone acetonide (TA) and bevacizumab. The objective of this review is to evaluate the evidence and discuss the rationale behind the recent suggestions that intravitreal pharmacotherapy by corticosteroids and anti-vascular endothelial growth factors may be useful in the treatment of retinal vein occlusion.展开更多
目的测量健康人群视网膜血管形态学几何参数(弯曲度、管径、分形维数),并探讨这些参数随年龄、性别、体质量指数(body mass index,BMI)的变化特征。方法观察性横断面研究。纳入147名健康人,拍摄眼底彩照,测量血管分形维数,测量距离视盘...目的测量健康人群视网膜血管形态学几何参数(弯曲度、管径、分形维数),并探讨这些参数随年龄、性别、体质量指数(body mass index,BMI)的变化特征。方法观察性横断面研究。纳入147名健康人,拍摄眼底彩照,测量血管分形维数,测量距离视盘中心1.5~3.0个视盘直径的视网膜动脉、静脉血管弯曲度和血管管径。按眼别、视网膜象限、性别、年龄、BMI分组,比较各组视网膜血管的分形维数、弯曲度、管径值。结果左右眼视网膜血管几何参数比较差异均无统计学意义(均为P>0.05)。颞侧与鼻侧象限视网膜动脉弯曲度、动静脉管径比较差异均有统计学意义(均为P<0.05)。男性与女性视网膜动静脉弯曲度、动静脉管径比较差异均无统计学意义(均为P>0.05),分形维数比较差异有统计学意义(P<0.05)。不同年龄亚组视网膜血管几何参数比较差异均有统计学意义(均为P<0.05),随年龄增大,视网膜动静脉弯曲度增加,视网膜动静脉管径、血管分形维数变小。不同BMI亚组视网膜动静脉管径比较差异有统计学意义(P<0.05);视网膜动静脉弯曲度、分形维数比较差异均无统计学意义(均为P>0.05);动静脉管径随BMI增高而减小。结论正常人群视网膜血管几何参数是微循环状态的潜在新生物标记,其随性别、年龄、BMI的不同而变化,且具有象限差异。展开更多
文摘Retinal vein occlusion (RVO) is the most common visually disabling disease affecting the retina after diabetic retinopathy. Although the disease entity has long been known, its management is still controversial. Macular edema is the main reason for decreased visual acuity (VA) in this retinal vascular disorder. Recently the vitreous cavity has increasingly been used as a reservoir of drugs for the direct treatment of macular edema through intravitreal injection route. The most widely injected drugs so far have been triamcinolone acetonide (TA) and bevacizumab. The objective of this review is to evaluate the evidence and discuss the rationale behind the recent suggestions that intravitreal pharmacotherapy by corticosteroids and anti-vascular endothelial growth factors may be useful in the treatment of retinal vein occlusion.
文摘目的测量健康人群视网膜血管形态学几何参数(弯曲度、管径、分形维数),并探讨这些参数随年龄、性别、体质量指数(body mass index,BMI)的变化特征。方法观察性横断面研究。纳入147名健康人,拍摄眼底彩照,测量血管分形维数,测量距离视盘中心1.5~3.0个视盘直径的视网膜动脉、静脉血管弯曲度和血管管径。按眼别、视网膜象限、性别、年龄、BMI分组,比较各组视网膜血管的分形维数、弯曲度、管径值。结果左右眼视网膜血管几何参数比较差异均无统计学意义(均为P>0.05)。颞侧与鼻侧象限视网膜动脉弯曲度、动静脉管径比较差异均有统计学意义(均为P<0.05)。男性与女性视网膜动静脉弯曲度、动静脉管径比较差异均无统计学意义(均为P>0.05),分形维数比较差异有统计学意义(P<0.05)。不同年龄亚组视网膜血管几何参数比较差异均有统计学意义(均为P<0.05),随年龄增大,视网膜动静脉弯曲度增加,视网膜动静脉管径、血管分形维数变小。不同BMI亚组视网膜动静脉管径比较差异有统计学意义(P<0.05);视网膜动静脉弯曲度、分形维数比较差异均无统计学意义(均为P>0.05);动静脉管径随BMI增高而减小。结论正常人群视网膜血管几何参数是微循环状态的潜在新生物标记,其随性别、年龄、BMI的不同而变化,且具有象限差异。
