【目的】研究柴胡疏肝散加味方治疗不宁腿综合征(restless legs syndrome,RLS)抑郁情绪的临床疗效。【方法】将64例肝郁血虚型RLS抑郁情绪患者随机分为对照组和观察组,每组各32例。对照组给予口服普拉克索缓释片治疗,观察组在对照组的...【目的】研究柴胡疏肝散加味方治疗不宁腿综合征(restless legs syndrome,RLS)抑郁情绪的临床疗效。【方法】将64例肝郁血虚型RLS抑郁情绪患者随机分为对照组和观察组,每组各32例。对照组给予口服普拉克索缓释片治疗,观察组在对照组的基础上给予柴胡舒肝散加味方治疗,疗程为4周。观察2组患者治疗前后国际不宁腿综合征严重程度评定量表(IRLS)、24项汉密尔顿抑郁量表(HAMD-24)、匹兹堡睡眠质量指数(PSQI)、中医证候积分量表评分及血清白细胞介素6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)含量变化,以评估2组患者治疗后RLS严重程度、抑郁程度、睡眠质量及炎症因子表达水平。【结果】(1)治疗4周后,观察组的总有效率为93.75%(30/32),对照组为87.50%(28/32);组间比较(秩和检验),观察组的临床疗效明显优于对照组(P<0.05)。(2)治疗后,2组患者的IRLS、HAMD及PSQI评分均较治疗前明显降低(P<0.01),且观察组对IRLS、HAMD及PSQI评分的降低幅度均明显优于对照组(P<0.05)。(3)治疗后,2组患者的中医证候积分均较治疗前明显降低(P<0.01),且观察组对中医证候积分的降低幅度明显优于对照组(P<0.01)。(4)治疗后,2组患者的血清IL-6、CRP、TNF-α水平均较治疗前明显降低(P<0.01),且观察组对血清IL-6、CRP、TNF-α水平的降低幅度均明显优于对照组(P<0.01)。【结论】柴胡疏肝散加味方联合普拉克索缓释片治疗肝郁血虚型RLS抑郁情绪患者疗效确切,相比单纯口服普拉克索缓释片更有助于改善患者RLS的严重程度、抑郁程度及睡眠质量,有效抑制炎症因子表达,改善患者生活质量。展开更多
芍药甘草汤具有解痉镇痛、抗感染、保肝、双向性调节等作用,可通过缓解肌肉痉挛、保护多巴胺能神经元等相关机制来达到治疗不宁腿综合征(restless legs syndrome,RLS)的目的。目前,关于芍药甘草汤治疗RLS具体机制的报道相对较少,缺乏基...芍药甘草汤具有解痉镇痛、抗感染、保肝、双向性调节等作用,可通过缓解肌肉痉挛、保护多巴胺能神经元等相关机制来达到治疗不宁腿综合征(restless legs syndrome,RLS)的目的。目前,关于芍药甘草汤治疗RLS具体机制的报道相对较少,缺乏基础实验研究,探究其分子机制难度较大,也缺乏多中心、大样本的临床研究及统一的疗效评价标准。因此,在今后的研究中应进行多中心、大样本的临床研究,逐步形成RLS治疗指南或专家共识,并制定疗效评价标准等;也可通过网络药理学等研究方式,通过多成分、多靶点的研究进一步分析RLS的相关分子机制。展开更多
Background: The prevalence of restless legs syndrome (RLS) is approximately 10% in general population. This condition is more prevalent in certain diseases and we previously reported the prevalence of RLS in chronic l...Background: The prevalence of restless legs syndrome (RLS) is approximately 10% in general population. This condition is more prevalent in certain diseases and we previously reported the prevalence of RLS in chronic liver disease population to be 62%. Objectives: Our aim was to assess the self-reported prevalence of RLS using an RLS symptom specific questionnaire in liver transplant patients. Methods: Subjects were a convenience sample in transplant clinic. They completed a validated survey for core RLS symptoms and if positive went on to completed a telephone survey using the validated International RLS Severity Scale Questionnaire (IRLS) and the Johns Hopkins RLS QoL survey to measure the effect of RLS symptoms on daily activities. Results: 40 patients surveyed, RLS was found in 16 subjects (40%) with moderate severity {17 (SD + 7.2, high score 31)}. Hepatitis C as indication for liver transplant was more likely associated with RLS (p = 0.05). Calcium channel blockers were protective (p = 0.032) while antidopaminergic agent use was statistically significant for RLS symptom (p = 0.005). On multiple linear regression analysis, diabetes (p = 0.024) and use of antidepressants/antihistamines (p = 0.049) were associated with RLS. Quality of Life (QoL) surveys specific to RLS suggested RLS symptoms resulted in significantly diminished QoL, with an average QoL score of 80 (SD + 11.7). Conclusion: There was a very high prevalence of RLS in our liver transplant patients with majority experiencing moderate or severe symptoms. The explanation for this higher prevalence is likely due to combination of comorbidites as well as medications that can trigger RLS.展开更多
目的研究健康受试者口服0.125mg和0.25mg普拉克索片的药动学过程,并评价该制剂的安全性,为注册治疗不宁腿综合征(restless leg syndrome,RLS)提供药动学依据。方法采用随机、开放、双向交叉试验设计,12名健康受试者(男女各半)分两个阶...目的研究健康受试者口服0.125mg和0.25mg普拉克索片的药动学过程,并评价该制剂的安全性,为注册治疗不宁腿综合征(restless leg syndrome,RLS)提供药动学依据。方法采用随机、开放、双向交叉试验设计,12名健康受试者(男女各半)分两个阶段分别进行单次口服普拉克索片0.125mg和0.25mg的药动学试验,两次给药间隔13天,每次给药前及给药后采集血样,采用液相色谱-串联质谱联用法(LC-MS/MS)测定健康受试者给药后血浆中普拉克索的浓度。采用WinNonlin(R)6.0版软件计算普拉克索片的药动学参数(AUC0-t、AUC0-∞﹑ρmax﹑tmax﹑t1/2﹑CL/F等)。整个试验过程进行全面安全性评估。结果单次口服普拉克索片0.125mg和0.25mg后,ρmax分别为(237±83)μg/L和(493±155)μg/L,tmax分别为(1.71±1.64)h和(1.21±1.01)h,t1/2分别为(6.12±2.21)h和(7.27±2.17)h,AUC0-∞分别为(1 791±765)μg·h·L-1和(4 419±1 932)μg·h·L-1,不同性别的药动学参数差异无统计学意义(P>0.05).试验过程无严重不良事件发生。结论单次口服0.125mg或0.25mg普拉克索吸收很快,吸收程度随剂量增加而增加,药动学过程不受性别影响.本研究制剂安全性较好,可按试验剂量给药治疗RLS。展开更多
文摘【目的】研究柴胡疏肝散加味方治疗不宁腿综合征(restless legs syndrome,RLS)抑郁情绪的临床疗效。【方法】将64例肝郁血虚型RLS抑郁情绪患者随机分为对照组和观察组,每组各32例。对照组给予口服普拉克索缓释片治疗,观察组在对照组的基础上给予柴胡舒肝散加味方治疗,疗程为4周。观察2组患者治疗前后国际不宁腿综合征严重程度评定量表(IRLS)、24项汉密尔顿抑郁量表(HAMD-24)、匹兹堡睡眠质量指数(PSQI)、中医证候积分量表评分及血清白细胞介素6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)含量变化,以评估2组患者治疗后RLS严重程度、抑郁程度、睡眠质量及炎症因子表达水平。【结果】(1)治疗4周后,观察组的总有效率为93.75%(30/32),对照组为87.50%(28/32);组间比较(秩和检验),观察组的临床疗效明显优于对照组(P<0.05)。(2)治疗后,2组患者的IRLS、HAMD及PSQI评分均较治疗前明显降低(P<0.01),且观察组对IRLS、HAMD及PSQI评分的降低幅度均明显优于对照组(P<0.05)。(3)治疗后,2组患者的中医证候积分均较治疗前明显降低(P<0.01),且观察组对中医证候积分的降低幅度明显优于对照组(P<0.01)。(4)治疗后,2组患者的血清IL-6、CRP、TNF-α水平均较治疗前明显降低(P<0.01),且观察组对血清IL-6、CRP、TNF-α水平的降低幅度均明显优于对照组(P<0.01)。【结论】柴胡疏肝散加味方联合普拉克索缓释片治疗肝郁血虚型RLS抑郁情绪患者疗效确切,相比单纯口服普拉克索缓释片更有助于改善患者RLS的严重程度、抑郁程度及睡眠质量,有效抑制炎症因子表达,改善患者生活质量。
文摘芍药甘草汤具有解痉镇痛、抗感染、保肝、双向性调节等作用,可通过缓解肌肉痉挛、保护多巴胺能神经元等相关机制来达到治疗不宁腿综合征(restless legs syndrome,RLS)的目的。目前,关于芍药甘草汤治疗RLS具体机制的报道相对较少,缺乏基础实验研究,探究其分子机制难度较大,也缺乏多中心、大样本的临床研究及统一的疗效评价标准。因此,在今后的研究中应进行多中心、大样本的临床研究,逐步形成RLS治疗指南或专家共识,并制定疗效评价标准等;也可通过网络药理学等研究方式,通过多成分、多靶点的研究进一步分析RLS的相关分子机制。
文摘Background: The prevalence of restless legs syndrome (RLS) is approximately 10% in general population. This condition is more prevalent in certain diseases and we previously reported the prevalence of RLS in chronic liver disease population to be 62%. Objectives: Our aim was to assess the self-reported prevalence of RLS using an RLS symptom specific questionnaire in liver transplant patients. Methods: Subjects were a convenience sample in transplant clinic. They completed a validated survey for core RLS symptoms and if positive went on to completed a telephone survey using the validated International RLS Severity Scale Questionnaire (IRLS) and the Johns Hopkins RLS QoL survey to measure the effect of RLS symptoms on daily activities. Results: 40 patients surveyed, RLS was found in 16 subjects (40%) with moderate severity {17 (SD + 7.2, high score 31)}. Hepatitis C as indication for liver transplant was more likely associated with RLS (p = 0.05). Calcium channel blockers were protective (p = 0.032) while antidopaminergic agent use was statistically significant for RLS symptom (p = 0.005). On multiple linear regression analysis, diabetes (p = 0.024) and use of antidepressants/antihistamines (p = 0.049) were associated with RLS. Quality of Life (QoL) surveys specific to RLS suggested RLS symptoms resulted in significantly diminished QoL, with an average QoL score of 80 (SD + 11.7). Conclusion: There was a very high prevalence of RLS in our liver transplant patients with majority experiencing moderate or severe symptoms. The explanation for this higher prevalence is likely due to combination of comorbidites as well as medications that can trigger RLS.
