Dexmedetomidine has sedative, anxiolytic, analgesic, anti-sympathetic, and anti-shivering effects. Dexmedetomidine might be effective in combination with sevoflurane for anesthesia, but prospective randomized controll...Dexmedetomidine has sedative, anxiolytic, analgesic, anti-sympathetic, and anti-shivering effects. Dexmedetomidine might be effective in combination with sevoflurane for anesthesia, but prospective randomized controlled clinical trials with which to verify this hypothesis are lacking. In total, 120 patients who underwent embolization of an intracranial aneurysm were recruited from Anhui Provincial Hospital and Renmin Hospital of Wuhan University of China and randomly allocated to two groups. After intraoperative administration of 2% to 3% sevoflurane inhalation, one group of patients received pump-controlled intravenous injection of 1.0 ~tg/kg dexmedetomidine for 15 minutes followed by maintenance with 0.3 ~tg/kg/h until the end of surgery; the other group of patients only underwent pump-controlled infusion of saline. Bispectral index monitoring revealed that dexmedetomidine-assisted anesthesia can shorten the recovery time of spon- taneous breathing, time to eye opening, and time to laryngeal mask removal. Before anesthetic induction and immediately after laryngeal mask airway removal, the glucose and lactate levels were low, the S100~ and neuron-specific enolase levels were low, the perioperative blood pressure and heart rate were stable, and postoperative delirium was minimal. These findings indicate that dexmedetomidine can effectively assist sevoflurane for anesthesia during surgical embolization of intracranial aneurysms, shorten the time to consciousness and extubation, reduce the stress response and energy metabolism, stabilize hemodynamic parameters, and reduce adverse reactions, thereby reducing the damage to the central nervous system. This trial was registered at the Chinese Clinical Trial Registry （http：//www.chictr.org. cn/） （registration number： ChiCTR-IPR- 16008113）.展开更多
如何对实施需求响应(demand response,DR)的成本效益进行有效评判是智能配电网(smart distribution network,SDN)规划中必须考虑的重要问题。为此,提出了一种综合评价模型。首先,通过分析当前电力市场环境下SDN参与主体及其利益需求,构...如何对实施需求响应(demand response,DR)的成本效益进行有效评判是智能配电网(smart distribution network,SDN)规划中必须考虑的重要问题。为此,提出了一种综合评价模型。首先,通过分析当前电力市场环境下SDN参与主体及其利益需求,构建了涵盖技术、经济、环境等多方面在内的DR效益综合评价指标体系。该体系通过引入区间型数据指标,能够有效计及各类不确定因素对DR效益的影响作用。在此基础上,根据问题特点,进一步提出了一种可适应上述不确定性条件下决策的区间灰色关联理想点分析方法。该方法采用专家打分和区间中心点距离法相结合的混合赋权策略,以实现对决策者主观意愿及评价指标自身信息价值的合理兼顾;此外,为避免分析过程中分辨系数选择不当对评价结果造成的不良影响,还提出了一种针对分辨系数的动态调整策略,以提高模型在实际应用中的鲁棒性及判别能力。算例结果验证了所提方法的有效性。展开更多
AIM:To determine the glycemic index(GI),glycemic load(GL)and insulinemic index(Ⅱ)of five starchy foods that are commonly used in Chinese diets.METHODS:Ten healthy subjects aged between 20-30 years were recruited.Each...AIM:To determine the glycemic index(GI),glycemic load(GL)and insulinemic index(Ⅱ)of five starchy foods that are commonly used in Chinese diets.METHODS:Ten healthy subjects aged between 20-30 years were recruited.Each subject was asked to consume 50 g of available carbohydrate portions of test foods and reference food.Finger capillary blood samples were collected at the start of eating and 15,30,45,60,90 and 120 min after consumption.The GI and Ⅱ of foods were calculated from the ratio of incremental area under the glucose/insulin response curves of test and reference foods.The GL for each test food was determined from its GI value and carbohydrate content.RESULTS:The results showed that brown rice elicited the highest postprandial glucose and insulin responses,followed by taro,adlay,yam and mung bean noodles,which produced the lowest.Among the five starchy foods,brown rice evoked the highest GI and GL at 82±0.2 and 18±0.2,followed by taro(69±0.4,12±0.2),adlay(55±0.4,10±0.2),yam(52±0.3,9±0.0)and mung bean noodles(28±0.5,7±0.2),respectively.The Ⅱ values of the test foods corresponded with GI values.Similarly,brown rice gave the highest Ⅱ at 81±0.1,followed by taro(73±0.3),adlay(67±0.3),yam(64±0.5) and mung bean noodles(38±0.3).All five starchy foods had lower GI,GL and Ⅱ than reference bread(P<0.05).CONCLUSION:The GI,GL and Ⅱ values of starchy foods provide important information for the public to manage their diet and could be useful for the prevention of lifestyle-related diseases such as diabetes mellitus.展开更多
A timely and accurate damage identification for bridge structures is essential to prevent sudden failures/collapses and other catastrophic accidents.Based on response surface model(RSM)updating and element modal strai...A timely and accurate damage identification for bridge structures is essential to prevent sudden failures/collapses and other catastrophic accidents.Based on response surface model(RSM)updating and element modal strain energy(EMSE)damage index,this paper proposes a novel damage identification method for girder bridge structures.The effectiveness of the proposed damage identification method is investigated using experiments on four simply supported steel beams.With Xiabaishi Bridge,a prestressed continuous rigid frame bridge with large span,as the engineering background,the proposed damage identification method is validated by using numerical simulation to generate different bearing damage scenarios.Finally,the efficiency of the method is justified by considering its application to identifying cracking damage for a real continuous beam bridge called Xinyihe Bridge.It is concluded that the EMSE damage index is sensitive to the cracking damage and the bearing damage.The locations and levels of multiple cracking damages and bearing damages can be also identified.The results illuminate a great potential of the proposed method in identifying damages of real bridge structures.展开更多
基金supported by the National Natural Science Foundation of China,No.81671891
文摘Dexmedetomidine has sedative, anxiolytic, analgesic, anti-sympathetic, and anti-shivering effects. Dexmedetomidine might be effective in combination with sevoflurane for anesthesia, but prospective randomized controlled clinical trials with which to verify this hypothesis are lacking. In total, 120 patients who underwent embolization of an intracranial aneurysm were recruited from Anhui Provincial Hospital and Renmin Hospital of Wuhan University of China and randomly allocated to two groups. After intraoperative administration of 2% to 3% sevoflurane inhalation, one group of patients received pump-controlled intravenous injection of 1.0 ~tg/kg dexmedetomidine for 15 minutes followed by maintenance with 0.3 ~tg/kg/h until the end of surgery; the other group of patients only underwent pump-controlled infusion of saline. Bispectral index monitoring revealed that dexmedetomidine-assisted anesthesia can shorten the recovery time of spon- taneous breathing, time to eye opening, and time to laryngeal mask removal. Before anesthetic induction and immediately after laryngeal mask airway removal, the glucose and lactate levels were low, the S100~ and neuron-specific enolase levels were low, the perioperative blood pressure and heart rate were stable, and postoperative delirium was minimal. These findings indicate that dexmedetomidine can effectively assist sevoflurane for anesthesia during surgical embolization of intracranial aneurysms, shorten the time to consciousness and extubation, reduce the stress response and energy metabolism, stabilize hemodynamic parameters, and reduce adverse reactions, thereby reducing the damage to the central nervous system. This trial was registered at the Chinese Clinical Trial Registry （http：//www.chictr.org. cn/） （registration number： ChiCTR-IPR- 16008113）.
文摘如何对实施需求响应(demand response,DR)的成本效益进行有效评判是智能配电网(smart distribution network,SDN)规划中必须考虑的重要问题。为此,提出了一种综合评价模型。首先,通过分析当前电力市场环境下SDN参与主体及其利益需求,构建了涵盖技术、经济、环境等多方面在内的DR效益综合评价指标体系。该体系通过引入区间型数据指标,能够有效计及各类不确定因素对DR效益的影响作用。在此基础上,根据问题特点,进一步提出了一种可适应上述不确定性条件下决策的区间灰色关联理想点分析方法。该方法采用专家打分和区间中心点距离法相结合的混合赋权策略,以实现对决策者主观意愿及评价指标自身信息价值的合理兼顾;此外,为避免分析过程中分辨系数选择不当对评价结果造成的不良影响,还提出了一种针对分辨系数的动态调整策略,以提高模型在实际应用中的鲁棒性及判别能力。算例结果验证了所提方法的有效性。
文摘AIM:To determine the glycemic index(GI),glycemic load(GL)and insulinemic index(Ⅱ)of five starchy foods that are commonly used in Chinese diets.METHODS:Ten healthy subjects aged between 20-30 years were recruited.Each subject was asked to consume 50 g of available carbohydrate portions of test foods and reference food.Finger capillary blood samples were collected at the start of eating and 15,30,45,60,90 and 120 min after consumption.The GI and Ⅱ of foods were calculated from the ratio of incremental area under the glucose/insulin response curves of test and reference foods.The GL for each test food was determined from its GI value and carbohydrate content.RESULTS:The results showed that brown rice elicited the highest postprandial glucose and insulin responses,followed by taro,adlay,yam and mung bean noodles,which produced the lowest.Among the five starchy foods,brown rice evoked the highest GI and GL at 82±0.2 and 18±0.2,followed by taro(69±0.4,12±0.2),adlay(55±0.4,10±0.2),yam(52±0.3,9±0.0)and mung bean noodles(28±0.5,7±0.2),respectively.The Ⅱ values of the test foods corresponded with GI values.Similarly,brown rice gave the highest Ⅱ at 81±0.1,followed by taro(73±0.3),adlay(67±0.3),yam(64±0.5) and mung bean noodles(38±0.3).All five starchy foods had lower GI,GL and Ⅱ than reference bread(P<0.05).CONCLUSION:The GI,GL and Ⅱ values of starchy foods provide important information for the public to manage their diet and could be useful for the prevention of lifestyle-related diseases such as diabetes mellitus.
基金The National Natural Science Foundation of China(Grant Nos.51178101 and 51378112)The University Graduate Student Scientific Research Innovation Plan of Jiangsu Province(Grant No.CXZZ13_0109)China Scholarship Council under Program for Graduate Student Overseas Study Scholarship
文摘A timely and accurate damage identification for bridge structures is essential to prevent sudden failures/collapses and other catastrophic accidents.Based on response surface model(RSM)updating and element modal strain energy(EMSE)damage index,this paper proposes a novel damage identification method for girder bridge structures.The effectiveness of the proposed damage identification method is investigated using experiments on four simply supported steel beams.With Xiabaishi Bridge,a prestressed continuous rigid frame bridge with large span,as the engineering background,the proposed damage identification method is validated by using numerical simulation to generate different bearing damage scenarios.Finally,the efficiency of the method is justified by considering its application to identifying cracking damage for a real continuous beam bridge called Xinyihe Bridge.It is concluded that the EMSE damage index is sensitive to the cracking damage and the bearing damage.The locations and levels of multiple cracking damages and bearing damages can be also identified.The results illuminate a great potential of the proposed method in identifying damages of real bridge structures.
