AIM: To evaluate the ability of the time-signal intensity curve (TIC) of the pancreas obtained from dynamic contrast-enhanced magnetic resonance imaging (MRI) for differentiation of focal pancreatic masses, especially...AIM: To evaluate the ability of the time-signal intensity curve (TIC) of the pancreas obtained from dynamic contrast-enhanced magnetic resonance imaging (MRI) for differentiation of focal pancreatic masses, especially pancreatic carcinoma coexisting with chronic pancreatitis and tumor-forming pancreatitis. METHODS: Forty-eight consecutive patients who underwent surgery for a focal pancreatic mass, including pancreatic ductal carcinoma (n = 33), tumor-forming pancreatitis (n = 8), and islet cell tumor (n = 7), were reviewed. Five pancreatic carcinomas coexisted with longstanding chronic pancreatitis. The pancreatic TICs were obtained from the pancreatic mass and the pancreatic parenchyma both proximal and distal to the mass lesion in each patient, prior to surgery, and were classified into 4 types according to the time to a peak: 25 s and 1, 2, and 3 min after the bolus injection of contrast material, namely, type-Ⅰ, Ⅱ, Ⅲ, and Ⅳ, respectively, and were then compared to the corresponding histological pancreatic conditions. RESULTS: Pancreatic carcinomas demonstrated type-Ⅲ (n = 13) or Ⅳ (n = 20) TIC. Tumor-forming pancreatitis showed type-Ⅱ (n = 5) or Ⅲ (n = 3) TIC. All islet cell tumors revealed type-Ⅰ. The type-Ⅳ TIC was only recognized in pancreatic carcinoma, and the TIC of carcinoma always depicted the slowest rise to a peak among the 3 pancreatic TICs measured in each patient, even in patients with chronic pancreatitis.CONCLUSION: Pancreatic TIC from dynamic MRI provides reliable information for distinguishing pancreatic carcinoma from other pancreatic masses, and may enable us to avoid unnecessary pancreatic surgery and delays in making a correct diagnosis of pancreatic carcinoma, especially, in patients with longstanding chronic pancreatitis.展开更多
In this paper,we reported an integrated method to generate ultra-wideband(UWB)pulses of different orders based on a reconfigurable silicon micro-ring resonator-coupled Mach–Zehnder interferometer.Under proper operati...In this paper,we reported an integrated method to generate ultra-wideband(UWB)pulses of different orders based on a reconfigurable silicon micro-ring resonator-coupled Mach–Zehnder interferometer.Under proper operating conditions,the device can produce Fano resonances with a peak-to-valley extinction ratio of above 20 dB.UWB monocycle and doublet signals with picosecond pulse widths are produced when the microring resonator is modulated by square and Gaussian electrical pulses,respectively.With our Fano resonance modulator on silicon photonics,it is promising to foresee versatile on-chip microwave signal generation.展开更多
To investigate the evaluation value of intravoxel incoherent motion diffusion-weighted imaging(IVIM-DWI)on the early efficacy of magnetic resonance-guided high-intensity focused ultrasound(MRgFUS)ablation for uterine ...To investigate the evaluation value of intravoxel incoherent motion diffusion-weighted imaging(IVIM-DWI)on the early efficacy of magnetic resonance-guided high-intensity focused ultrasound(MRgFUS)ablation for uterine adenomyoma.The clinical and magnetic resonance imaging(MRI)data of 36 patients with uterine adenomyoma before and after MRgFUS treatment in our hospital from January 2018 to December 2018 were retrospectively analyzed.All the 36 patients underwent MRI examination one day before operation and immediately after operation using GE Discovery MR7503.0T MRI,including conventional sequences(T1WI,T2WI,and T2 fat suppression sequences)plain scan,IVIM-DWI sequences with 9 b values,and contrast enhanced-MRI sequences.The IVIM-DWI quantitative parameters(true diffusion coefficient D,perfusion related diffusion coefficient D*,and perfusion fraction f)of double-exponential model were obtained by using GE ADW 4.7 functool,a postprocessor.SPSS 24.0 software was used to analyze the difference in parameter between the ablation and non-ablation areas of uterine adenomyoma.DWI signal in the ablation area of uterine adenomyoma was increased,and manifested as heterogeneous diffuse high signal,with low central signal and high edge signal.Values of D,D*and f in the ablation area of uterine adenomyoma were significantly lower than those in the non-ablation area,and there was statistical difference between the two(P<0.05).The areas under receiver operating characteristic(ROC)curve of D,D*and f values in the ablation area of uterine adenomyoma were 0.854,0.898 and 0.924,respectively;the optimal thresholds for the diagnosis of ablation area of uterine adenomyoma were 0.81×10−3 mm2/s,4.99×10−3 mm2/s and 0.24,respectively;the diagnostic sensitivity was 80.6%,72.2%and 94.4%,respectively;and the specificity was 91.7%,97.2%and 94.4%,respectively.IVIM-DWI has a certain clinical value in the evaluation on early efficacy of MRgFUS ablation of uterine adenomyosis.展开更多
Hyperbolic metamaterials(HMMs) are novel artificial materials that excite the surface plasmon resonance(SPR) because of their unique hyperbolic dispersion properties. Herein, to the best of our knowledge, we propose t...Hyperbolic metamaterials(HMMs) are novel artificial materials that excite the surface plasmon resonance(SPR) because of their unique hyperbolic dispersion properties. Herein, to the best of our knowledge, we propose the first HMM-based fiber SPR(HMM-SPR) sensor for vector magnetic detection. By selecting the composite materials and structural parameters of the HMM dispersion management, HMM-SPR sensors can achieve a high refractive index sensitivity of 14.43 μm/RIU. Vector magnetic field detection was performed with the HMM-SPR sensor encapsulated with a magnetic fluid. Compared with other ferrofluidbased magnetic field fiber sensors, the proposed sensor shows pronounced advantages in intensity and direction sensitivity of 1.307 nm/Oe and 7.116 nm/°, respectively. The sensor design approach presented in this paper provides an excellent demonstration of HMM-SPR sensors in various applications.展开更多
Locally resonant metamaterial plates with subwavelength bandgaps can be exploited for the simultaneous control of structural vibrations and acoustic radiation.The present work theoretically investigates the vibroacous...Locally resonant metamaterial plates with subwavelength bandgaps can be exploited for the simultaneous control of structural vibrations and acoustic radiation.The present work theoretically investigates the vibroacoustic characteristics of a metamaterial plate with periodic lateral local resonance.The high accuracy of the presented method is evident from the consistency of the cross mobility of the metamaterial plate calculated with the finite element technique.The modal superposition approach and Rayleigh integral technique are adopted to formulate the mean square velocity and acoustic radiation power in terms of the structural deflection and sound pressure to capture the vibroacoustic coupling characteristics of the metamaterial plate and the surrounding environment.Large vibration suppression and sound reduction with high radiation efficiency can be observed within the frequency ranges of interest.The near-field sound intensity and far-field acoustic pressure distributions inside and outside the bandgaps are plotted and analyzed.The results from this work can be utilized to set design guidelines for metamaterial design to achieve prescribed vibroacoustic characteristics.展开更多
文摘AIM: To evaluate the ability of the time-signal intensity curve (TIC) of the pancreas obtained from dynamic contrast-enhanced magnetic resonance imaging (MRI) for differentiation of focal pancreatic masses, especially pancreatic carcinoma coexisting with chronic pancreatitis and tumor-forming pancreatitis. METHODS: Forty-eight consecutive patients who underwent surgery for a focal pancreatic mass, including pancreatic ductal carcinoma (n = 33), tumor-forming pancreatitis (n = 8), and islet cell tumor (n = 7), were reviewed. Five pancreatic carcinomas coexisted with longstanding chronic pancreatitis. The pancreatic TICs were obtained from the pancreatic mass and the pancreatic parenchyma both proximal and distal to the mass lesion in each patient, prior to surgery, and were classified into 4 types according to the time to a peak: 25 s and 1, 2, and 3 min after the bolus injection of contrast material, namely, type-Ⅰ, Ⅱ, Ⅲ, and Ⅳ, respectively, and were then compared to the corresponding histological pancreatic conditions. RESULTS: Pancreatic carcinomas demonstrated type-Ⅲ (n = 13) or Ⅳ (n = 20) TIC. Tumor-forming pancreatitis showed type-Ⅱ (n = 5) or Ⅲ (n = 3) TIC. All islet cell tumors revealed type-Ⅰ. The type-Ⅳ TIC was only recognized in pancreatic carcinoma, and the TIC of carcinoma always depicted the slowest rise to a peak among the 3 pancreatic TICs measured in each patient, even in patients with chronic pancreatitis.CONCLUSION: Pancreatic TIC from dynamic MRI provides reliable information for distinguishing pancreatic carcinoma from other pancreatic masses, and may enable us to avoid unnecessary pancreatic surgery and delays in making a correct diagnosis of pancreatic carcinoma, especially, in patients with longstanding chronic pancreatitis.
基金supported by the National Natural Science Foundation of China(62175061,52172140,52221001,and 52072117)the Natural Science Foundation of Hunan Province(2022JJ30167)+1 种基金the Outstanding Scholarship Program of Hunan Province(2021JJ10021)China Postdoctoral Science Foundation(BX20220104,2022M720046 and 2022TQ0100)。
基金The project was supported by the National Natural Science Foundation of China(21161013)Natural Science Foundation of Inner Mongolia,China(2011MS0202)Opening Foundation for Significant Fundamental Research of Inner Mongolia,China(2010KF03)~~
基金the National Key Research and Development Program(Nos.2019YFB2203203 and 2018YFB2201702)the National Natural Science Foundation of China(NSFC)(Grant Nos.61705129 and 61535006)+1 种基金the Shanghai Municipal Science and Technology Major Project(No.2017SHZDZX03)the Open Project Program of Wuhan National Laboratory for Optoelectronics(No.2019WNLOKF004)。
文摘In this paper,we reported an integrated method to generate ultra-wideband(UWB)pulses of different orders based on a reconfigurable silicon micro-ring resonator-coupled Mach–Zehnder interferometer.Under proper operating conditions,the device can produce Fano resonances with a peak-to-valley extinction ratio of above 20 dB.UWB monocycle and doublet signals with picosecond pulse widths are produced when the microring resonator is modulated by square and Gaussian electrical pulses,respectively.With our Fano resonance modulator on silicon photonics,it is promising to foresee versatile on-chip microwave signal generation.
文摘To investigate the evaluation value of intravoxel incoherent motion diffusion-weighted imaging(IVIM-DWI)on the early efficacy of magnetic resonance-guided high-intensity focused ultrasound(MRgFUS)ablation for uterine adenomyoma.The clinical and magnetic resonance imaging(MRI)data of 36 patients with uterine adenomyoma before and after MRgFUS treatment in our hospital from January 2018 to December 2018 were retrospectively analyzed.All the 36 patients underwent MRI examination one day before operation and immediately after operation using GE Discovery MR7503.0T MRI,including conventional sequences(T1WI,T2WI,and T2 fat suppression sequences)plain scan,IVIM-DWI sequences with 9 b values,and contrast enhanced-MRI sequences.The IVIM-DWI quantitative parameters(true diffusion coefficient D,perfusion related diffusion coefficient D*,and perfusion fraction f)of double-exponential model were obtained by using GE ADW 4.7 functool,a postprocessor.SPSS 24.0 software was used to analyze the difference in parameter between the ablation and non-ablation areas of uterine adenomyoma.DWI signal in the ablation area of uterine adenomyoma was increased,and manifested as heterogeneous diffuse high signal,with low central signal and high edge signal.Values of D,D*and f in the ablation area of uterine adenomyoma were significantly lower than those in the non-ablation area,and there was statistical difference between the two(P<0.05).The areas under receiver operating characteristic(ROC)curve of D,D*and f values in the ablation area of uterine adenomyoma were 0.854,0.898 and 0.924,respectively;the optimal thresholds for the diagnosis of ablation area of uterine adenomyoma were 0.81×10−3 mm2/s,4.99×10−3 mm2/s and 0.24,respectively;the diagnostic sensitivity was 80.6%,72.2%and 94.4%,respectively;and the specificity was 91.7%,97.2%and 94.4%,respectively.IVIM-DWI has a certain clinical value in the evaluation on early efficacy of MRgFUS ablation of uterine adenomyosis.
基金supported by the National Natural Science Foundation of China (Grant Nos. 62175094, 61904067, 61805108, and 62075088)Basic and Applied Basic Research Foundation of Guangdong Province (Grant Nos. 2022A1515011671, 2022A1515010272, and 2020A1515011498)+2 种基金Basic and Applied Basic Research Foundation of Guangzhou (Grant No. 202102020758)Science and Technology R&D Project of Shenzhen (Grant Nos. JSGG20201102163800003, and JSGG20210713091806021)Fundamental Research Funds for the Central Universities (Grant Nos. 21621405, and 21620328)。
文摘Hyperbolic metamaterials(HMMs) are novel artificial materials that excite the surface plasmon resonance(SPR) because of their unique hyperbolic dispersion properties. Herein, to the best of our knowledge, we propose the first HMM-based fiber SPR(HMM-SPR) sensor for vector magnetic detection. By selecting the composite materials and structural parameters of the HMM dispersion management, HMM-SPR sensors can achieve a high refractive index sensitivity of 14.43 μm/RIU. Vector magnetic field detection was performed with the HMM-SPR sensor encapsulated with a magnetic fluid. Compared with other ferrofluidbased magnetic field fiber sensors, the proposed sensor shows pronounced advantages in intensity and direction sensitivity of 1.307 nm/Oe and 7.116 nm/°, respectively. The sensor design approach presented in this paper provides an excellent demonstration of HMM-SPR sensors in various applications.
基金supported by the National Natural Science Foundation of China(No.52001131 and No.52071152).
文摘Locally resonant metamaterial plates with subwavelength bandgaps can be exploited for the simultaneous control of structural vibrations and acoustic radiation.The present work theoretically investigates the vibroacoustic characteristics of a metamaterial plate with periodic lateral local resonance.The high accuracy of the presented method is evident from the consistency of the cross mobility of the metamaterial plate calculated with the finite element technique.The modal superposition approach and Rayleigh integral technique are adopted to formulate the mean square velocity and acoustic radiation power in terms of the structural deflection and sound pressure to capture the vibroacoustic coupling characteristics of the metamaterial plate and the surrounding environment.Large vibration suppression and sound reduction with high radiation efficiency can be observed within the frequency ranges of interest.The near-field sound intensity and far-field acoustic pressure distributions inside and outside the bandgaps are plotted and analyzed.The results from this work can be utilized to set design guidelines for metamaterial design to achieve prescribed vibroacoustic characteristics.
