AIM: To determine the insulin resistance (IR) and oxidative status in H pylori infection and to find out if there is any relationship between these parameters and insulin resistance. METHODS: Fifty-five H pylori posit...AIM: To determine the insulin resistance (IR) and oxidative status in H pylori infection and to find out if there is any relationship between these parameters and insulin resistance. METHODS: Fifty-five H pylori positive and 48 H pylori negative patients were enrolled. The homeostasis model assessment (HOMA) was used to assess insulin resistance. Serum total antioxidant capacity (TAC), total oxidant status (TOS) and oxidative stress index (OSI) were determined in all subjects. RESULTS: The total antioxidant capacity was significantly lower in H pylori positive group than in H pylori negative group (1.36 ± 0.33 and 1.70 ± 0.50, respectively; P < 0.001), while the total oxidant status and oxidative stress index were significantly higher in H pylori positive group than in H pylori negative group (6.79 ± 3.40 and 5.08 ± 0.95, and 5.42 ± 3.40 and 3.10 ± 0.92, respectively; P < 0.001). Insulin resistance was significantly higher in H pylori positive group than in H pylori negative group (6.92 ± 3.86 and 3.61 ± 1.67, res- pectively; P < 0.001). Insulin resistance was found to be significantly correlated with total antioxidant capacity (r = -0.251, P < 0.05), total oxidant status (r = 0.365, P < 0.05), and oxidative stress index (r = 0.267, P < 0.05). CONCLUSION: Insulin resistance seems to be associated with increased oxidative stress in H pylori infection. Further studies are needed to clarify the mechanisms underlying this association and elucidate the effectof adding antioxidant vitamins to H pylori eradication therapy on insulin resistance during H pylori infection.展开更多
目的:调查耐药肺结核患者的营养状况并分析其影响因素。方法:采用回顾性研究方法,于2020年1月1日至2021年12月31日搜集中国17个省和2个直辖市共29家结核病专科医院的耐药肺结核患者作为研究对象,最终纳入1766例,年龄范围为18~90岁,平均...目的:调查耐药肺结核患者的营养状况并分析其影响因素。方法:采用回顾性研究方法,于2020年1月1日至2021年12月31日搜集中国17个省和2个直辖市共29家结核病专科医院的耐药肺结核患者作为研究对象,最终纳入1766例,年龄范围为18~90岁,平均年龄为(45.88±16.43)岁;平均体质量指数(body mass index, BMI)为20.03±3.25;其中,男性1255例(71.06%),女性511例(28.94%)。收集研究对象的人口学信息及临床特征资料;使用营养风险筛查简表(NRS-2002)评估研究对象是否存在营养风险,进一步的营养不良的评估及诊断参照全球营养不良领导倡议标准(global leadership initiative on malnutrition, GLIM)进行。采用多因素logistic回归分析耐药肺结核患者发生营养风险的影响因素。结果:1766例研究对象NRS-2002评分波动于1~5分,得分中位数(四分位数)为3(1~4)分;共1103例(62.46%)研究对象存在营养风险(NRS-2002≥3分)。NRS-2002评分≥3分组中,60~79岁者占70.56%(254/360),≥80岁者占83.33%(25/30),BMI<18.5者占100.0%(602/602),均明显高于NRS-2002评分<3分组[分别占29.44%(106/360)、16.67%(5/30)、0],差异均有统计学意义(χ2值分别为6.256和1345.000,P值分别为0.012和<0.01)。多因素logistic回归分析显示,高龄(≥60岁)[以18~39岁组为参照,60~79岁组:OR(95%CI)=2.130(1.194~3.803);≥80岁组:OR(95%CI)=12.400(3.114~49.369)]和低BMI[以BMI≥20.5者为参照,BMI<18.5者:OR(95%CI)=56.937(26.537~122.161)]是耐药肺结核患者发生营养风险的危险因素。研究对象营养不良发生率为52.55%(928/1766),1103例存在营养风险者中,营养不良发生率为84.13%(928/1103)。结论:耐药肺结核患者存在较高的营养风险,营养不良发生率较高,应对此类患者尽早行规范的营养风险筛查及营养不良的诊断,尤其关注高龄及低BMI患者。展开更多
文摘AIM: To determine the insulin resistance (IR) and oxidative status in H pylori infection and to find out if there is any relationship between these parameters and insulin resistance. METHODS: Fifty-five H pylori positive and 48 H pylori negative patients were enrolled. The homeostasis model assessment (HOMA) was used to assess insulin resistance. Serum total antioxidant capacity (TAC), total oxidant status (TOS) and oxidative stress index (OSI) were determined in all subjects. RESULTS: The total antioxidant capacity was significantly lower in H pylori positive group than in H pylori negative group (1.36 ± 0.33 and 1.70 ± 0.50, respectively; P < 0.001), while the total oxidant status and oxidative stress index were significantly higher in H pylori positive group than in H pylori negative group (6.79 ± 3.40 and 5.08 ± 0.95, and 5.42 ± 3.40 and 3.10 ± 0.92, respectively; P < 0.001). Insulin resistance was significantly higher in H pylori positive group than in H pylori negative group (6.92 ± 3.86 and 3.61 ± 1.67, res- pectively; P < 0.001). Insulin resistance was found to be significantly correlated with total antioxidant capacity (r = -0.251, P < 0.05), total oxidant status (r = 0.365, P < 0.05), and oxidative stress index (r = 0.267, P < 0.05). CONCLUSION: Insulin resistance seems to be associated with increased oxidative stress in H pylori infection. Further studies are needed to clarify the mechanisms underlying this association and elucidate the effectof adding antioxidant vitamins to H pylori eradication therapy on insulin resistance during H pylori infection.
文摘目的:调查耐药肺结核患者的营养状况并分析其影响因素。方法:采用回顾性研究方法,于2020年1月1日至2021年12月31日搜集中国17个省和2个直辖市共29家结核病专科医院的耐药肺结核患者作为研究对象,最终纳入1766例,年龄范围为18~90岁,平均年龄为(45.88±16.43)岁;平均体质量指数(body mass index, BMI)为20.03±3.25;其中,男性1255例(71.06%),女性511例(28.94%)。收集研究对象的人口学信息及临床特征资料;使用营养风险筛查简表(NRS-2002)评估研究对象是否存在营养风险,进一步的营养不良的评估及诊断参照全球营养不良领导倡议标准(global leadership initiative on malnutrition, GLIM)进行。采用多因素logistic回归分析耐药肺结核患者发生营养风险的影响因素。结果:1766例研究对象NRS-2002评分波动于1~5分,得分中位数(四分位数)为3(1~4)分;共1103例(62.46%)研究对象存在营养风险(NRS-2002≥3分)。NRS-2002评分≥3分组中,60~79岁者占70.56%(254/360),≥80岁者占83.33%(25/30),BMI<18.5者占100.0%(602/602),均明显高于NRS-2002评分<3分组[分别占29.44%(106/360)、16.67%(5/30)、0],差异均有统计学意义(χ2值分别为6.256和1345.000,P值分别为0.012和<0.01)。多因素logistic回归分析显示,高龄(≥60岁)[以18~39岁组为参照,60~79岁组:OR(95%CI)=2.130(1.194~3.803);≥80岁组:OR(95%CI)=12.400(3.114~49.369)]和低BMI[以BMI≥20.5者为参照,BMI<18.5者:OR(95%CI)=56.937(26.537~122.161)]是耐药肺结核患者发生营养风险的危险因素。研究对象营养不良发生率为52.55%(928/1766),1103例存在营养风险者中,营养不良发生率为84.13%(928/1103)。结论:耐药肺结核患者存在较高的营养风险,营养不良发生率较高,应对此类患者尽早行规范的营养风险筛查及营养不良的诊断,尤其关注高龄及低BMI患者。
