Low frequency （≤ 1 Hz） repetitive transcranial magnetic stimulation （rTMS） can affect the excitability of the cerebral cortex and synaptic plasticity. Although this is a common method for clinical treatment of ce...Low frequency （≤ 1 Hz） repetitive transcranial magnetic stimulation （rTMS） can affect the excitability of the cerebral cortex and synaptic plasticity. Although this is a common method for clinical treatment of cerebral infarction, whether it promotes the recovery of motor function remains controversial. Twenty patients with cerebral infarction combined with hemiparalysis were equally and randomly divided into a low frequency rTMS group and a control group. The patients in the low frequency rTMS group were given 1-Hz rTMS to the contralateral primary motor cortex with a stimulus intensity of 90% motor threshold, 30 minutes/day. The patients in the control group were given sham stimulation. After 14 days of treatment, clinical function scores （National Institute of Health Stroke Scale, Barthel Index, and Fugl-Meyer Assessment） improved significantly in the low frequency rTMS group, and the effects were better than that in the control group. We conclude that low frequency （1 Hz） rTMS for 14 days can help improve motor function after cerebral infarction.展开更多
Studies have confirmed that low-frequency repetitive transcranial magnetic stimulation can decrease the activity of cortical neurons, and high-frequency repetitive transcranial magnetic stimulation can increase the ex...Studies have confirmed that low-frequency repetitive transcranial magnetic stimulation can decrease the activity of cortical neurons, and high-frequency repetitive transcranial magnetic stimulation can increase the excitability of cortical neurons. However, there are few studies concerning the use of different frequencies of repetitive transcranial magnetic stimulation on the recovery of upper-limb motor function after cerebral infarction. We hypothesized that different frequencies of repetitive transcranial magnetic stimulation in patients with cerebral infarction would produce different effects on the recovery of upper-limb motor function. This study enrolled 127 patients with upper-limb dysfunction during the subacute phase of cerebral infarction. These patients were randomly assigned to three groups. The low-frequency group comprised 42 patients who were treated with 1 Hz repetitive transcranial magnetic stimulation on the contralateral hemisphere primary motor cortex （M1）. The high-frequency group comprised 43 patients who were treated with 10 Hz repetitive transcranial magnetic stimulation on ipsilateral M1. Finally, the sham group comprised 42 patients who were treated with 10 Hz of false stimulation on ipsilateral M1. A total of 135 seconds of stimulation was applied in the sham group and high-frequency group. At 2 weeks after treatment, cortical latency of motor-evoked potentials and central motor conduction time were significantly lower compared with before treatment. Moreover, motor function scores were significantly improved. The above indices for the low- and high-frequency groups were significantly different compared with the sham group. However, there was no significant difference between the low- and high-frequency groups. The results show that low- and high-frequency repetitive transcranial magnetic stimulation can similarly improve upper-limb motor function in patients with cerebral infarction.展开更多
目的探讨重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)治疗急性脑梗死后吞咽障碍中功能磁共振成像(functional magnetic resonance imaging,fMRI)相关指标的变化及关系。方法选取2018年6月至2019年6月于我院神...目的探讨重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)治疗急性脑梗死后吞咽障碍中功能磁共振成像(functional magnetic resonance imaging,fMRI)相关指标的变化及关系。方法选取2018年6月至2019年6月于我院神经内科住院的急性脑梗死后吞咽障碍的患者共40例,随机分为2组,分别为rTMS组和假刺激组,分析两组患者干预前和干预后的低频振幅(amplitude of low frequency fluctuation,ALFF)值的变化,采用临床吞咽困难量表(clinical dysphagia scale,CDS)、吞咽困难预后和严重程度量表(dysphagia prognosis and severity scale,DOSS)评估其吞咽功能变化,同时分析CDS和DOSS评分与ALFF值变化的关系。结果两组患者干预前的CDS和DOSS评分对比差异无统计学意义(P>0.05),干预后rTMS组的CDS评分低于假刺激组,且DOSS评分高于假刺激组,差异有统计学意义(P<0.05)。干预后rTMS组较假刺激组患者ALFF增强的脑区包括双侧尾状核、双侧豆状核和双侧额上回(P<0.05),且双侧尾状核、豆状核和额上回的ALFF变化与CDS评分和DOSS评分变化存在相关性(P<0.05)。结论rTMS治疗急性脑梗死吞咽障碍的患者可以促进大脑双侧尾状核、豆状核和额上回连接功能增强和激活。展开更多
基金supported by the National Natural Science Foundation of China,No.30540058,30770714the Natural Science Foundation of Beijing of China,No.7052030+2 种基金the Talents Foundation of Organization Department of the Beijing Municipal Committee in Chinathe Beijing Science Plan Project Fund of China,No.Z0005187040191-1the Research Foundation of Capital Medical Development of China,No.2007-2068
文摘Low frequency （≤ 1 Hz） repetitive transcranial magnetic stimulation （rTMS） can affect the excitability of the cerebral cortex and synaptic plasticity. Although this is a common method for clinical treatment of cerebral infarction, whether it promotes the recovery of motor function remains controversial. Twenty patients with cerebral infarction combined with hemiparalysis were equally and randomly divided into a low frequency rTMS group and a control group. The patients in the low frequency rTMS group were given 1-Hz rTMS to the contralateral primary motor cortex with a stimulus intensity of 90% motor threshold, 30 minutes/day. The patients in the control group were given sham stimulation. After 14 days of treatment, clinical function scores （National Institute of Health Stroke Scale, Barthel Index, and Fugl-Meyer Assessment） improved significantly in the low frequency rTMS group, and the effects were better than that in the control group. We conclude that low frequency （1 Hz） rTMS for 14 days can help improve motor function after cerebral infarction.
基金several colleague therapists of the Rehabilitation Medicine Department of the Affiliated Hospital of Qingdao University of China for their support and selfless help
文摘Studies have confirmed that low-frequency repetitive transcranial magnetic stimulation can decrease the activity of cortical neurons, and high-frequency repetitive transcranial magnetic stimulation can increase the excitability of cortical neurons. However, there are few studies concerning the use of different frequencies of repetitive transcranial magnetic stimulation on the recovery of upper-limb motor function after cerebral infarction. We hypothesized that different frequencies of repetitive transcranial magnetic stimulation in patients with cerebral infarction would produce different effects on the recovery of upper-limb motor function. This study enrolled 127 patients with upper-limb dysfunction during the subacute phase of cerebral infarction. These patients were randomly assigned to three groups. The low-frequency group comprised 42 patients who were treated with 1 Hz repetitive transcranial magnetic stimulation on the contralateral hemisphere primary motor cortex （M1）. The high-frequency group comprised 43 patients who were treated with 10 Hz repetitive transcranial magnetic stimulation on ipsilateral M1. Finally, the sham group comprised 42 patients who were treated with 10 Hz of false stimulation on ipsilateral M1. A total of 135 seconds of stimulation was applied in the sham group and high-frequency group. At 2 weeks after treatment, cortical latency of motor-evoked potentials and central motor conduction time were significantly lower compared with before treatment. Moreover, motor function scores were significantly improved. The above indices for the low- and high-frequency groups were significantly different compared with the sham group. However, there was no significant difference between the low- and high-frequency groups. The results show that low- and high-frequency repetitive transcranial magnetic stimulation can similarly improve upper-limb motor function in patients with cerebral infarction.
文摘目的探讨重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)治疗急性脑梗死后吞咽障碍中功能磁共振成像(functional magnetic resonance imaging,fMRI)相关指标的变化及关系。方法选取2018年6月至2019年6月于我院神经内科住院的急性脑梗死后吞咽障碍的患者共40例,随机分为2组,分别为rTMS组和假刺激组,分析两组患者干预前和干预后的低频振幅(amplitude of low frequency fluctuation,ALFF)值的变化,采用临床吞咽困难量表(clinical dysphagia scale,CDS)、吞咽困难预后和严重程度量表(dysphagia prognosis and severity scale,DOSS)评估其吞咽功能变化,同时分析CDS和DOSS评分与ALFF值变化的关系。结果两组患者干预前的CDS和DOSS评分对比差异无统计学意义(P>0.05),干预后rTMS组的CDS评分低于假刺激组,且DOSS评分高于假刺激组,差异有统计学意义(P<0.05)。干预后rTMS组较假刺激组患者ALFF增强的脑区包括双侧尾状核、双侧豆状核和双侧额上回(P<0.05),且双侧尾状核、豆状核和额上回的ALFF变化与CDS评分和DOSS评分变化存在相关性(P<0.05)。结论rTMS治疗急性脑梗死吞咽障碍的患者可以促进大脑双侧尾状核、豆状核和额上回连接功能增强和激活。
