A series of mesoporous silica with variable pore structures were prepared.The influence of mesoporous structure on drug release profiles was studied.It is found that mesoporous pore structure has a great effect on the...A series of mesoporous silica with variable pore structures were prepared.The influence of mesoporous structure on drug release profiles was studied.It is found that mesoporous pore structure has a great effect on the drug release rate.The cubic pore structure MCM-48 has a faster drug release rate than that of MCM-41 system;while SBA-16 with 'cage-like' pore structure system has the lowest drug release rate.展开更多
An oil-in-water (O/W) solvent evaporation method was used to prepare biodegradable microspheresbased on poly(D,L-lactic acid) (PLA). Nifedipine, a hydrophobic drug, was chosen as a model molecule in the studyof drug e...An oil-in-water (O/W) solvent evaporation method was used to prepare biodegradable microspheresbased on poly(D,L-lactic acid) (PLA). Nifedipine, a hydrophobic drug, was chosen as a model molecule in the studyof drug entrapment and release. Effect of preparation conditions on the size, morphology, drug loading, and releaseprofiles of micropheres was investigated. Based on in vitro release experimental findings, a diffusion/dissolutionmodel was presented for quantitative description of the resulting release behaviors and drug release kinetics fromPLA microspheres analyzed. The mathematical models were used to predict the effect of microstructure on theresulting drug release. It provided an approach to determine the suitable structure parameters for microspheres toachieve desired drug release behaviors.展开更多
文摘A series of mesoporous silica with variable pore structures were prepared.The influence of mesoporous structure on drug release profiles was studied.It is found that mesoporous pore structure has a great effect on the drug release rate.The cubic pore structure MCM-48 has a faster drug release rate than that of MCM-41 system;while SBA-16 with 'cage-like' pore structure system has the lowest drug release rate.
文摘An oil-in-water (O/W) solvent evaporation method was used to prepare biodegradable microspheresbased on poly(D,L-lactic acid) (PLA). Nifedipine, a hydrophobic drug, was chosen as a model molecule in the studyof drug entrapment and release. Effect of preparation conditions on the size, morphology, drug loading, and releaseprofiles of micropheres was investigated. Based on in vitro release experimental findings, a diffusion/dissolutionmodel was presented for quantitative description of the resulting release behaviors and drug release kinetics fromPLA microspheres analyzed. The mathematical models were used to predict the effect of microstructure on theresulting drug release. It provided an approach to determine the suitable structure parameters for microspheres toachieve desired drug release behaviors.
