What is New in 2016？In 2016,the journal will focus on publishing the innovative changes in protection,repair,and regeneration processes after nerve injury,which will interest the readership of Neural Regeneration Res...What is New in 2016？In 2016,the journal will focus on publishing the innovative changes in protection,repair,and regeneration processes after nerve injury,which will interest the readership of Neural Regeneration Research（NRR）.In addition to providing indexing in international databases,how does NRR benefit authors and readers？What are the responsibilities and duties of NRR’s editorial board members？What are the editorial work standards to which all NRR editors should adhere？展开更多
Over 200,000 Americans have peripheral nerve injuries annually that result in a loss of function and a compromised quality of life.Of these,a significant percent involves unsuccessful repair of peripheral nerve gaps t...Over 200,000 Americans have peripheral nerve injuries annually that result in a loss of function and a compromised quality of life.Of these,a significant percent involves unsuccessful repair of peripheral nerve gaps that occur due to traumatic limb injury or collateral damage to peripheral nerves during tumor resection.展开更多
The glial regenerative response to central nervous system（CNS） injury,although limited,can be harnessed to promote regeneration and repair.Injury provokes the proliferation of ensheathing glial cells,which can diffe...The glial regenerative response to central nervous system（CNS） injury,although limited,can be harnessed to promote regeneration and repair.Injury provokes the proliferation of ensheathing glial cells,which can differentiate to remyelinate axons,and partially restore function.This response is evolutionarily conserved,strongly implying an underlying genetic mechanism.In mammals,it is elicited by NG2 glia,but most often newly generated cells fail to differentiate.Thus an important goal had been to find out how to promote glial differentiation following the proliferative response.A gene network involving Notch and prospero（pros） controls the balance between glial proliferation and differentiation in flies and mice,and promotes CNS repair at least in fruit-flies.A key missing link had been how to relate the function of NG2 to this gene network.Recent findings by Losada-Perez et al.,published in JCB,demonstrated that the Drosophila NG2 homologue kon-tiki（kon） is functionally linked to Notch and pros in glia.By engaging in two feedback loops with Notch and Pros,in response to injury,Kon can regulate both glial cell number and glial shape homeostasis,essential for repair.Drosophila offers powerful genetics to unravel the control of stem and progenitor cells for regeneration and repair.展开更多
文摘What is New in 2016？In 2016,the journal will focus on publishing the innovative changes in protection,repair,and regeneration processes after nerve injury,which will interest the readership of Neural Regeneration Research（NRR）.In addition to providing indexing in international databases,how does NRR benefit authors and readers？What are the responsibilities and duties of NRR’s editorial board members？What are the editorial work standards to which all NRR editors should adhere？
文摘Over 200,000 Americans have peripheral nerve injuries annually that result in a loss of function and a compromised quality of life.Of these,a significant percent involves unsuccessful repair of peripheral nerve gaps that occur due to traumatic limb injury or collateral damage to peripheral nerves during tumor resection.
文摘The glial regenerative response to central nervous system（CNS） injury,although limited,can be harnessed to promote regeneration and repair.Injury provokes the proliferation of ensheathing glial cells,which can differentiate to remyelinate axons,and partially restore function.This response is evolutionarily conserved,strongly implying an underlying genetic mechanism.In mammals,it is elicited by NG2 glia,but most often newly generated cells fail to differentiate.Thus an important goal had been to find out how to promote glial differentiation following the proliferative response.A gene network involving Notch and prospero（pros） controls the balance between glial proliferation and differentiation in flies and mice,and promotes CNS repair at least in fruit-flies.A key missing link had been how to relate the function of NG2 to this gene network.Recent findings by Losada-Perez et al.,published in JCB,demonstrated that the Drosophila NG2 homologue kon-tiki（kon） is functionally linked to Notch and pros in glia.By engaging in two feedback loops with Notch and Pros,in response to injury,Kon can regulate both glial cell number and glial shape homeostasis,essential for repair.Drosophila offers powerful genetics to unravel the control of stem and progenitor cells for regeneration and repair.
