In this Letter, the surface-enhanced Raman scattering(SERS) signal of early breast cancer(BRC) patient serum is obtained by a composite silver nanoparticles(Ag NPs) PSi Bragg reflector SERS substrate. Based on these a...In this Letter, the surface-enhanced Raman scattering(SERS) signal of early breast cancer(BRC) patient serum is obtained by a composite silver nanoparticles(Ag NPs) PSi Bragg reflector SERS substrate. Based on these advantages, the serum SERS signals of 30 normal people and 30 early BRC patients were detected by this substrate. After a baseline correction of the experimental data, principal component analysis and linear discriminant analysis were used to complete the data processing. The results showed that the diagnostic accuracy, specificity,and sensitivity of the composite Ag NPs PSi Bragg reflector SERS substrate were 95%, 96.7%, and 93.3%, respectively. The results of this exploratory study prove that the detection of early BRC serum based on a composite Ag NPs PSi Bragg reflector SERS substrate is with a stable strong SERS signal, and an unmarked and noninvasive BRC diagnosis technology. In the future, this technology can serve as a noninvasive clinical tool to detect cancer diseases and have a considerable impact on clinical medical detection.展开更多
设计了中心波长为520 nm的AlGaInN/InGaN应变补偿分布布拉格反射镜(DBR)结构,通过调节组分参数实现应变补偿,使DBR整体应变为0,采用传输矩阵法,计算了Al_(0.7)Ga_(0.3-x)In x N/InGaN DBR、Al_(0.8)Ga_(0.2-x)In x N/InGaN DBR、Al_(0.9...设计了中心波长为520 nm的AlGaInN/InGaN应变补偿分布布拉格反射镜(DBR)结构,通过调节组分参数实现应变补偿,使DBR整体应变为0,采用传输矩阵法,计算了Al_(0.7)Ga_(0.3-x)In x N/InGaN DBR、Al_(0.8)Ga_(0.2-x)In x N/InGaN DBR、Al_(0.9)Ga_(0.1-x)In x N/InGaN DBR的反射光谱。通过对DBR结构参数进行对比,优化了其结构和反射性能。首先对比高低折射率层生长顺序,发现对于Al_(0.8)Ga_(0.14)In_(0.06)N/In_(0.123)Ga_(0.877)N DBR,先生长高折射率层时,反射率高达99.61%,而先生长低折射率层时,反射率仅为97.73%;然后对比奇数层DBR和偶数层DBR,发现两者的反射谱几乎重合,没有显著区别;通过研究DBR对数对反射率的影响,发现对数在20~30对时,反射率随着对数的增加明显上升,30~40对时反射率增长缓慢;最后研究了材料组分对反射谱的影响,发现Al组分高的DBR折射率差大,反射性能更优,而相同Al组分的AlGaInN中In含量越低反射率越高。考虑到DBR制备过程中可能出现的厚度和组分偏差,模拟了厚度和组分出现偏差时反射谱的变化,发现高低折射率层厚度每增加或减少1 nm,反射谱红移或蓝移4~5 nm;而组分的偏差使高反射带带宽和中心波长处反射率发生明显变化。本文的研究为AlGaInN/InGaN DBR的设计和制备提供了一定的理论参考。展开更多
基金the National Natural Science Foundation of China (Nos. 61665012,61575168,61765014)the International Science Cooperation Project of the Ministry of Education of the People’s Republic of China (No. 2016–2196)the Reserve Talents Project of National High-level Personnel of the Special Support Program (No. QN2016YX0324)。
文摘In this Letter, the surface-enhanced Raman scattering(SERS) signal of early breast cancer(BRC) patient serum is obtained by a composite silver nanoparticles(Ag NPs) PSi Bragg reflector SERS substrate. Based on these advantages, the serum SERS signals of 30 normal people and 30 early BRC patients were detected by this substrate. After a baseline correction of the experimental data, principal component analysis and linear discriminant analysis were used to complete the data processing. The results showed that the diagnostic accuracy, specificity,and sensitivity of the composite Ag NPs PSi Bragg reflector SERS substrate were 95%, 96.7%, and 93.3%, respectively. The results of this exploratory study prove that the detection of early BRC serum based on a composite Ag NPs PSi Bragg reflector SERS substrate is with a stable strong SERS signal, and an unmarked and noninvasive BRC diagnosis technology. In the future, this technology can serve as a noninvasive clinical tool to detect cancer diseases and have a considerable impact on clinical medical detection.
文摘设计了中心波长为520 nm的AlGaInN/InGaN应变补偿分布布拉格反射镜(DBR)结构,通过调节组分参数实现应变补偿,使DBR整体应变为0,采用传输矩阵法,计算了Al_(0.7)Ga_(0.3-x)In x N/InGaN DBR、Al_(0.8)Ga_(0.2-x)In x N/InGaN DBR、Al_(0.9)Ga_(0.1-x)In x N/InGaN DBR的反射光谱。通过对DBR结构参数进行对比,优化了其结构和反射性能。首先对比高低折射率层生长顺序,发现对于Al_(0.8)Ga_(0.14)In_(0.06)N/In_(0.123)Ga_(0.877)N DBR,先生长高折射率层时,反射率高达99.61%,而先生长低折射率层时,反射率仅为97.73%;然后对比奇数层DBR和偶数层DBR,发现两者的反射谱几乎重合,没有显著区别;通过研究DBR对数对反射率的影响,发现对数在20~30对时,反射率随着对数的增加明显上升,30~40对时反射率增长缓慢;最后研究了材料组分对反射谱的影响,发现Al组分高的DBR折射率差大,反射性能更优,而相同Al组分的AlGaInN中In含量越低反射率越高。考虑到DBR制备过程中可能出现的厚度和组分偏差,模拟了厚度和组分出现偏差时反射谱的变化,发现高低折射率层厚度每增加或减少1 nm,反射谱红移或蓝移4~5 nm;而组分的偏差使高反射带带宽和中心波长处反射率发生明显变化。本文的研究为AlGaInN/InGaN DBR的设计和制备提供了一定的理论参考。
