This article analyses the procedure of exploration of the Tertiary subtle trap in Jiyang depression and divides the Tertiary subtle trap into 3 types (lithologic reservoir, stratigraphic reservoir and fractured reserv...This article analyses the procedure of exploration of the Tertiary subtle trap in Jiyang depression and divides the Tertiary subtle trap into 3 types (lithologic reservoir, stratigraphic reservoir and fractured reservoir) and 8 groups, then summarizes the common feature and founding discipline of the subtle trap and finds 4 accumulating modes including steep slope mode, depression mode, center anticline mode and gentle slope mode. Its main exploration methods are explicated from the viewpoint of reservoir geological modeling, description of recognizing traps and comprehensive evaluation of reservoir and so on.展开更多
The carbon films are prepared by r.f. plasma method with n butylamine as carbon source. The analysis of Raman spectrosecopy shows that this kind of carbon film has diamond_like structure, and IR spectroscopy measureme...The carbon films are prepared by r.f. plasma method with n butylamine as carbon source. The analysis of Raman spectrosecopy shows that this kind of carbon film has diamond_like structure, and IR spectroscopy measurement indicats that there are SP 2 bonding, SP 3 bonding and amino group in the film. It is the existence of amino group and hydrogen atom that cause the amorphous structure and the deformation of bonding to increase, thus leading the Raman spectrum to form a broad absorption band. The quartz crystal microbalance (QCM) deposited with this kind of carbon film as recognizing coating is very sensitive to formic acid vapors. This QCM sensor has good reproducibility, high stability, rapid response and long lifetime.展开更多
Background China is progressing towards the goal of schistosomiasis elimination,but there are still some problems,such as difficult management of infection source and snail control.This study aimed to develop deep lea...Background China is progressing towards the goal of schistosomiasis elimination,but there are still some problems,such as difficult management of infection source and snail control.This study aimed to develop deep learning models with high-resolution remote sensing images for recognizing and monitoring livestock bovine,which is an intermediate source of Schistosoma japonicum infection,and to evaluate the effectiveness of the models for real-world application.Methods The dataset of livestock bovine’s spatial distribution was collected from the Chinese National Platform for Common Geospatial Information Services.The high-resolution remote sensing images were further divided into training data,test data,and validation data for model development.Two recognition models based on deep learning methods(ENVINet5 and Mask R-CNN)were developed with reference to the training datasets.The performance of the developed models was evaluated by the performance metrics of precision,recall,and F1-score.Results A total of 50 typical image areas were selected,1125 bovine objectives were labeled by the ENVINet5 model and 1277 bovine objectives were labeled by the Mask R-CNN model.For the ENVINet5 model,a total of 1598 records of bovine distribution were recognized.The model precision and recall were 81.9%and 80.2%,respectively.The F1 score was 0.81.For the Mask R-CNN mode,1679 records of bovine objectives were identified.The model precision and recall were 87.3%and 85.2%,respectively.The F1 score was 0.87.When applying the developed models to real-world schistosomiasis-endemic regions,there were 63 bovine objectives in the original image,53 records were extracted using the ENVINet5 model,and 57 records were extracted using the Mask R-CNN model.The successful recognition ratios were 84.1%and 90.5%for the respectively developed models.Conclusion The ENVINet5 model is very feasible when the bovine distribution is low in structure with few samples.The Mask R-CNN model has a good framework design and runs highly efficiently.The livestock展开更多
Bone sialoprotein-binding protein （Bbp）, a MSCRAMMs （Microbial Surface Components Recognizing Adhesive Matrix Molecules） family protein expressed on the surface of Staphylococcus aureus （S. aureus）, mediates adh...Bone sialoprotein-binding protein （Bbp）, a MSCRAMMs （Microbial Surface Components Recognizing Adhesive Matrix Molecules） family protein expressed on the surface of Staphylococcus aureus （S. aureus）, mediates adherence to fibrinogen a （Fg a）, a component in the extracellular matrix of the host cell and is important for infection and pathogenesis. In this study, we solved the crystal structures of apo-Bbp273-598 and Bbp273-598-Fg a561-575 complex at a resolution of 2.03 A and 1.45 A, respectively. Apo-Bbp273-598 contained the ligand binding region N2 and N3 domains, both of which followed a DE variant IgG fold characterized by an additional DI strand in N2 domain and D1＇ and D2＇ strands in N3 domain. The peptide mapped to the Fg o561-575 bond to Bbp273-sgs on the open groove between the N2 and N3 domains. Strikingly, the disordered C-terminus in the apo-form reorganized into a highly-ordered loop and a β-strand G＂ covering the ligand upon ligand binding. BbpAla298-Gly301 in the N2 domain of the Bbp273-598-Fg a561-575 complex, which is a loop in the apo-form, formed a short a-helix to interact tightly with the peptide. In addition, Bbpser547-Glns61 in the N3 domain moved toward the binding groove to make contact directly with the peptide, while BbpAsp338-Gly355 and BbpThr365-Tyr387 in N2 domain shifted their configurations to stabilize the reorganized C-terminus mainly through strong hydrogen bonds. Altogether, our results revealed the molecular basis for Bbp-ligand interaction and advanced our understanding of S. aureus infection process.展开更多
In this paper,we show several arithmetic properties on the residues of binomial coefficients and their products modulo prime powers,e.g.. for any distinct odd primes p and q.Meanwhile.we discuss the connections with ...In this paper,we show several arithmetic properties on the residues of binomial coefficients and their products modulo prime powers,e.g.. for any distinct odd primes p and q.Meanwhile.we discuss the connections with the prime recognitions.展开更多
Faced with a socio-political-mediatic arena that continues to return the ballet of pandemic,climate change,fourth industrial revolution,sixth mass extinction,war etc.,the reflection of Michel Serres and Posthumanism p...Faced with a socio-political-mediatic arena that continues to return the ballet of pandemic,climate change,fourth industrial revolution,sixth mass extinction,war etc.,the reflection of Michel Serres and Posthumanism put forth instances for silencing of the anthropocentric logos,and for recognition of the multiplicity,variety,possibility of things and of the human in co-belonging with them,as well as instances for working on these same multiplicities,varieties,possibilities,that are often absences,black holes,repressed of philosophical thought.展开更多
文摘This article analyses the procedure of exploration of the Tertiary subtle trap in Jiyang depression and divides the Tertiary subtle trap into 3 types (lithologic reservoir, stratigraphic reservoir and fractured reservoir) and 8 groups, then summarizes the common feature and founding discipline of the subtle trap and finds 4 accumulating modes including steep slope mode, depression mode, center anticline mode and gentle slope mode. Its main exploration methods are explicated from the viewpoint of reservoir geological modeling, description of recognizing traps and comprehensive evaluation of reservoir and so on.
文摘The carbon films are prepared by r.f. plasma method with n butylamine as carbon source. The analysis of Raman spectrosecopy shows that this kind of carbon film has diamond_like structure, and IR spectroscopy measurement indicats that there are SP 2 bonding, SP 3 bonding and amino group in the film. It is the existence of amino group and hydrogen atom that cause the amorphous structure and the deformation of bonding to increase, thus leading the Raman spectrum to form a broad absorption band. The quartz crystal microbalance (QCM) deposited with this kind of carbon film as recognizing coating is very sensitive to formic acid vapors. This QCM sensor has good reproducibility, high stability, rapid response and long lifetime.
基金National Natural Science Foundation of China(No.32161143036,No.82173633,No.81960374)Science and Technology research project of Shanghai Municipal Health Commission(No.20194Y0359)National Key Research and Development Program of China(No.2021YFC2300800,2021YFC2300803)
文摘Background China is progressing towards the goal of schistosomiasis elimination,but there are still some problems,such as difficult management of infection source and snail control.This study aimed to develop deep learning models with high-resolution remote sensing images for recognizing and monitoring livestock bovine,which is an intermediate source of Schistosoma japonicum infection,and to evaluate the effectiveness of the models for real-world application.Methods The dataset of livestock bovine’s spatial distribution was collected from the Chinese National Platform for Common Geospatial Information Services.The high-resolution remote sensing images were further divided into training data,test data,and validation data for model development.Two recognition models based on deep learning methods(ENVINet5 and Mask R-CNN)were developed with reference to the training datasets.The performance of the developed models was evaluated by the performance metrics of precision,recall,and F1-score.Results A total of 50 typical image areas were selected,1125 bovine objectives were labeled by the ENVINet5 model and 1277 bovine objectives were labeled by the Mask R-CNN model.For the ENVINet5 model,a total of 1598 records of bovine distribution were recognized.The model precision and recall were 81.9%and 80.2%,respectively.The F1 score was 0.81.For the Mask R-CNN mode,1679 records of bovine objectives were identified.The model precision and recall were 87.3%and 85.2%,respectively.The F1 score was 0.87.When applying the developed models to real-world schistosomiasis-endemic regions,there were 63 bovine objectives in the original image,53 records were extracted using the ENVINet5 model,and 57 records were extracted using the Mask R-CNN model.The successful recognition ratios were 84.1%and 90.5%for the respectively developed models.Conclusion The ENVINet5 model is very feasible when the bovine distribution is low in structure with few samples.The Mask R-CNN model has a good framework design and runs highly efficiently.The livestock
文摘Bone sialoprotein-binding protein （Bbp）, a MSCRAMMs （Microbial Surface Components Recognizing Adhesive Matrix Molecules） family protein expressed on the surface of Staphylococcus aureus （S. aureus）, mediates adherence to fibrinogen a （Fg a）, a component in the extracellular matrix of the host cell and is important for infection and pathogenesis. In this study, we solved the crystal structures of apo-Bbp273-598 and Bbp273-598-Fg a561-575 complex at a resolution of 2.03 A and 1.45 A, respectively. Apo-Bbp273-598 contained the ligand binding region N2 and N3 domains, both of which followed a DE variant IgG fold characterized by an additional DI strand in N2 domain and D1＇ and D2＇ strands in N3 domain. The peptide mapped to the Fg o561-575 bond to Bbp273-sgs on the open groove between the N2 and N3 domains. Strikingly, the disordered C-terminus in the apo-form reorganized into a highly-ordered loop and a β-strand G＂ covering the ligand upon ligand binding. BbpAla298-Gly301 in the N2 domain of the Bbp273-598-Fg a561-575 complex, which is a loop in the apo-form, formed a short a-helix to interact tightly with the peptide. In addition, Bbpser547-Glns61 in the N3 domain moved toward the binding groove to make contact directly with the peptide, while BbpAsp338-Gly355 and BbpThr365-Tyr387 in N2 domain shifted their configurations to stabilize the reorganized C-terminus mainly through strong hydrogen bonds. Altogether, our results revealed the molecular basis for Bbp-ligand interaction and advanced our understanding of S. aureus infection process.
基金Supported partly by NNSFCA Presidential Faculty Fellowsupported in part by the NSF of the United States
文摘In this paper,we show several arithmetic properties on the residues of binomial coefficients and their products modulo prime powers,e.g.. for any distinct odd primes p and q.Meanwhile.we discuss the connections with the prime recognitions.
文摘Faced with a socio-political-mediatic arena that continues to return the ballet of pandemic,climate change,fourth industrial revolution,sixth mass extinction,war etc.,the reflection of Michel Serres and Posthumanism put forth instances for silencing of the anthropocentric logos,and for recognition of the multiplicity,variety,possibility of things and of the human in co-belonging with them,as well as instances for working on these same multiplicities,varieties,possibilities,that are often absences,black holes,repressed of philosophical thought.
