AIM: To investigate that inflammatory markers can predict accurately the prognosis of hepatocelluar carcinoma (HCC) patients in living-donor liver transplantation (LDLT).
Background The importance of sheep breeding in the Mediterranean part of the eastern Adriatic has a long tradition since its arrival during the Neolithic migrations.Sheep production system is extensive and generally c...Background The importance of sheep breeding in the Mediterranean part of the eastern Adriatic has a long tradition since its arrival during the Neolithic migrations.Sheep production system is extensive and generally carried out in traditional systems without intensive systematic breeding programmes for high uniform trait production(carcass,wool and milk yield).Therefore,eight indigenous Croatian sheep breeds from eastern Adriatic treated here as metapopulation(EAS),are generally considered as multipurpose breeds(milk,meat and wool),not specialised for a particular type of production,but known for their robustness and resistance to certain environmental conditions.Our objective was to identify genomic regions and genes that exhibit patterns of positive selection signatures,decipher their biological and productive functionality,and provide a"genomic"characterization of EAS adaptation and determine its production type.Results We identified positive selection signatures in EAS using several methods based on reduced local variation,linkage disequilibrium and site frequency spectrum(eROHi,iHS,nSL and CLR).Our analyses identified numerous genomic regions and genes(e.g.,desmosomal cadherin and desmoglein gene families)associated with environmental adaptation and economically important traits.Most candidate genes were related to meat/production and health/immune response traits,while some of the candidate genes discovered were important for domestication and evolutionary processes(e.g.,HOXa gene family and FSIP2).These results were also confirmed by GO and QTL enrichment analysis.Conclusions Our results contribute to a better understanding of the unique adaptive genetic architecture of EAS and define its productive type,ultimately providing a new opportunity for future breeding programmes.At the same time,the numerous genes identified will improve our understanding of ruminant(sheep)robustness and resistance in the harsh and specific Mediterranean environment.展开更多
基于水波扩散效应,提出了一种水波中心扩散算法(water wave center diffusion,WWCD)。着眼解决函数极值优化问题,以某个局部最优解为中心点,由近至远、由密至疏产生多组扩散解进行迭代寻优。通过合理设计扩散解的扩散比例、选择比例和...基于水波扩散效应,提出了一种水波中心扩散算法(water wave center diffusion,WWCD)。着眼解决函数极值优化问题,以某个局部最优解为中心点,由近至远、由密至疏产生多组扩散解进行迭代寻优。通过合理设计扩散解的扩散比例、选择比例和跳跃比例等参数,提高算法的全局寻优效率,对比WWCD与6种智能优化算法极值优化问题的仿真结果,验证了前者在全局求解精度和收敛速度方面的优越性。聚焦雷达信号识别问题,WWCD优化支持向量机(support vector machine,SVM)关键参数进行雷达信号识别实验。仿真结果表明,通过本算法优化SVM关键参数进行雷达信号识别,可明显提高识别效率。展开更多
Mutualisms are cooperative interactions between members of different species. We focus on obligate mutualism, where each species cannot survive without the other. From a theoretical aspect, obligate mutualism is simil...Mutualisms are cooperative interactions between members of different species. We focus on obligate mutualism, where each species cannot survive without the other. From a theoretical aspect, obligate mutualism is similar to the relationship between male and female. Empirical data indicate a sex-ratio selection: male and female have a specific ratio in their population sizes. In the present paper, we apply lattice model to obligate mutualism between two species, and present a theory of “ratio selection” which is a generalization of sex-ratio selection. Computer simulations are carried out by two methods: local and global interactions. In the former, interactions occur between neighbouring cells, while in the latter they occur between any pair of cells. Simulations in both interactions show the so-called Allee effect: both species can survive, when both densities are large in some extent. However, we find a large difference between local and global simulations. In the case of local interaction, restriction for survival is found to be extremely severe compared to global interaction. Both species require a proper ratio for their sustainability. This result leads to the theory of ratio selection: when interaction occurs locally, the ratio of both species is uniquely determined. We discuss that the ratio selection explains not only the evolution of endosymbionts from free-living ancestors but also the evolution from endosymbionts to organelles.展开更多
This paper presents an RF receiver of zero-Intermediate Frequency(IF) architecture for Cognitive Radio(CR) communication systems.Zero-IF architecture reduce the image reject filter and IF filter,so it is excellent in ...This paper presents an RF receiver of zero-Intermediate Frequency(IF) architecture for Cognitive Radio(CR) communication systems.Zero-IF architecture reduce the image reject filter and IF filter,so it is excellent in low cost,compact volume,and low power dissipation.The receiver employs three digital attenuator and a high gain,high linearity low noise amplifier to achieve wide dynamic range of 70 dB and high receiving sensitivity of-81 dBm.A fully balanced I/Q demodulator and a differential Local Oscillator(LO) chips are used to minimize the negative effects caused by second-order distortion and LO leakage.In order to select an 8 MHz-channel from 14 continuous ones located in UHF band(694-806 MHz) accurately,approach of channel selectivity circuits is proposed.The RF receiver has been designed,fabricated,and test.The measured result shows that the noise figure is 3.4 dB,and the error vector magnitude is 7.5% when the input power is-81 dBm.展开更多
文摘AIM: To investigate that inflammatory markers can predict accurately the prognosis of hepatocelluar carcinoma (HCC) patients in living-donor liver transplantation (LDLT).
基金supported by Croatian Science Foundation project IP-2018–01-8708-Application of NGS methods in the assessment of genomic variability in ruminants–“ANAGRAMS”the EU Operational Program Competitiveness and Cohesion 2014–2020 project KK.01.1.1.04.0058—Potential of microencapsulation in cheese productionthe project No.QK1919156 of the Ministry of Agriculture,Czech Republic.
文摘Background The importance of sheep breeding in the Mediterranean part of the eastern Adriatic has a long tradition since its arrival during the Neolithic migrations.Sheep production system is extensive and generally carried out in traditional systems without intensive systematic breeding programmes for high uniform trait production(carcass,wool and milk yield).Therefore,eight indigenous Croatian sheep breeds from eastern Adriatic treated here as metapopulation(EAS),are generally considered as multipurpose breeds(milk,meat and wool),not specialised for a particular type of production,but known for their robustness and resistance to certain environmental conditions.Our objective was to identify genomic regions and genes that exhibit patterns of positive selection signatures,decipher their biological and productive functionality,and provide a"genomic"characterization of EAS adaptation and determine its production type.Results We identified positive selection signatures in EAS using several methods based on reduced local variation,linkage disequilibrium and site frequency spectrum(eROHi,iHS,nSL and CLR).Our analyses identified numerous genomic regions and genes(e.g.,desmosomal cadherin and desmoglein gene families)associated with environmental adaptation and economically important traits.Most candidate genes were related to meat/production and health/immune response traits,while some of the candidate genes discovered were important for domestication and evolutionary processes(e.g.,HOXa gene family and FSIP2).These results were also confirmed by GO and QTL enrichment analysis.Conclusions Our results contribute to a better understanding of the unique adaptive genetic architecture of EAS and define its productive type,ultimately providing a new opportunity for future breeding programmes.At the same time,the numerous genes identified will improve our understanding of ruminant(sheep)robustness and resistance in the harsh and specific Mediterranean environment.
文摘Mutualisms are cooperative interactions between members of different species. We focus on obligate mutualism, where each species cannot survive without the other. From a theoretical aspect, obligate mutualism is similar to the relationship between male and female. Empirical data indicate a sex-ratio selection: male and female have a specific ratio in their population sizes. In the present paper, we apply lattice model to obligate mutualism between two species, and present a theory of “ratio selection” which is a generalization of sex-ratio selection. Computer simulations are carried out by two methods: local and global interactions. In the former, interactions occur between neighbouring cells, while in the latter they occur between any pair of cells. Simulations in both interactions show the so-called Allee effect: both species can survive, when both densities are large in some extent. However, we find a large difference between local and global simulations. In the case of local interaction, restriction for survival is found to be extremely severe compared to global interaction. Both species require a proper ratio for their sustainability. This result leads to the theory of ratio selection: when interaction occurs locally, the ratio of both species is uniquely determined. We discuss that the ratio selection explains not only the evolution of endosymbionts from free-living ancestors but also the evolution from endosymbionts to organelles.
基金Supported by the National High-Tech Project (No. 2009AA011801)National Natural Science Foundation of China (No. 60621002)
文摘This paper presents an RF receiver of zero-Intermediate Frequency(IF) architecture for Cognitive Radio(CR) communication systems.Zero-IF architecture reduce the image reject filter and IF filter,so it is excellent in low cost,compact volume,and low power dissipation.The receiver employs three digital attenuator and a high gain,high linearity low noise amplifier to achieve wide dynamic range of 70 dB and high receiving sensitivity of-81 dBm.A fully balanced I/Q demodulator and a differential Local Oscillator(LO) chips are used to minimize the negative effects caused by second-order distortion and LO leakage.In order to select an 8 MHz-channel from 14 continuous ones located in UHF band(694-806 MHz) accurately,approach of channel selectivity circuits is proposed.The RF receiver has been designed,fabricated,and test.The measured result shows that the noise figure is 3.4 dB,and the error vector magnitude is 7.5% when the input power is-81 dBm.
