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中医临床研究设计类型的优化 被引量:13
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作者 田元祥 翁维良 陆芳 《中华中医药杂志》 CAS CSCD 北大核心 2010年第4期556-559,共4页
中医临床研究根据研究目的,选用不同类型设计。中医临床探索性研究过程多选用横断面研究、叙述性研究(如病例报告、病例分析等)设计,验证性研究多选用随机对照试验设计。随机对照试验最常用于治疗性或预防性研究,方法比较成熟。随机交... 中医临床研究根据研究目的,选用不同类型设计。中医临床探索性研究过程多选用横断面研究、叙述性研究(如病例报告、病例分析等)设计,验证性研究多选用随机对照试验设计。随机对照试验最常用于治疗性或预防性研究,方法比较成熟。随机交叉试验设计,应考虑顺序效应的影响,双盲法是最佳选择。队列研究因为不涉及随机分配患者和盲法,在中医临床研究中可用多种干预措施。病例-对照研究适应面宽,但偏倚较多。横断面研究是中医证候调查常用设计方法。叙述性研究是中医临床经验总结、中医探索性研究的常用设计方法。随机方法推荐第三方中央在线网络随机系统,可靠性高,随机化不易被破坏,注重随机隐藏。在不能采用盲法时,盲态测评也可减少测量偏倚,阳性对照必须有高级别证据的支持。安慰剂使用可提高循证证据级别。 展开更多
关键词 临床试验 中医 设计类型 优化 随机 盲法 对照
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宫廷理筋振髌法治疗膝骨性关节炎的临床研究 被引量:12
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作者 王锡友 臧福科 +5 位作者 刘长信 刘焰刚 付焘 李多多 杨晓明 于长禾 《中华中医药杂志》 CAS CSCD 北大核心 2020年第6期3251-3254,共4页
目的:为临床推广臧福科教授的宫廷理筋振髌法,提供理论和实践依据。方法:选取2013年9月至2015年5月的63例膝骨性关节炎(KOA)患者,分为治疗组采用宫廷理筋振髌法,对照组采用传统推拿手法,治疗1个周期。比较治疗前后KOA严重指数(ISOA)评... 目的:为临床推广臧福科教授的宫廷理筋振髌法,提供理论和实践依据。方法:选取2013年9月至2015年5月的63例膝骨性关节炎(KOA)患者,分为治疗组采用宫廷理筋振髌法,对照组采用传统推拿手法,治疗1个周期。比较治疗前后KOA严重指数(ISOA)评分、疼痛视觉模拟评分(VAS),西安大略麦马斯特大学骨性关节炎指数可视化量表(WOMAC)评分的变化情况。结果:治疗组总有效率93.75%,对照组总有效率74.19%,两组治疗后各项评分均较治疗前明显改善,有显著性差异(P<0.01)。经秩和检验,即认为两组临床疗效评价有显著性差异,治疗组疗效优于对照组(P<0.05)。结论:宫廷理筋振髌法及传统推拿手法均有临床疗效;宫廷理筋振髌法治疗KOA临床疗效更肯定。宫廷理筋振髌法治疗KOA安全有效,操作规范,值得进一步临床研究。 展开更多
关键词 宫廷理筋振髌法 膝骨性关节炎 疗效评价 随机 试验 推拿
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标准的和2周一疗程CHOP方案治疗进展型非霍奇金氏淋巴瘤的随机对照研究 被引量:9
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作者 林桐榆 管忠震 +6 位作者 姜文奇 何友兼 徐光川 刘冬耕 黄慧强 滕小玉 徐瑞华 《癌症》 SCIE CAS CSCD 北大核心 1999年第6期697-701,共5页
目的 :观察缩短常规CHOP方案的化疗间隙 ,能否提高进展型NHL的治疗效果。方法 :93例初治的进展型NHL被随机分成试验组和对照组 ,试验组 46例患者在G CSF的支持下使用 2周的CHOP方案治疗 ,对照组 47例病人用常规的 3周CHOP方案治疗 ,两... 目的 :观察缩短常规CHOP方案的化疗间隙 ,能否提高进展型NHL的治疗效果。方法 :93例初治的进展型NHL被随机分成试验组和对照组 ,试验组 46例患者在G CSF的支持下使用 2周的CHOP方案治疗 ,对照组 47例病人用常规的 3周CHOP方案治疗 ,两方案的化疗药物剂量相同。结果 :试验组和对照组的CR率分别为 80 4%和 6 6 0 % ,2年DFS分别为 5 2 17%和 40 43 % ;按IPI属高中度 /高度危险性的患者在试验组和对照组的CR率为 76 9%和 3 7 5 % ,2年DFS为 3 8 46 %和 12 5 0 % ;按IPI属中低度 /低度危险性者在试验组和对照组的CR率为 81 8%和 80 6 % ,2年DFS为 5 7 88%和 5 4 84% ;两组患者的毒性反应相似 ,均可耐受。结论 :缩短CHOP方案的化疗间隙 ,有可能提高按IPI属中高度 /高度危险性进展型NHL患者的治疗效果 ,而中低度 展开更多
关键词 淋巴瘤 NHL 药物疗法 CHOP方案
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福多司坦治疗慢性阻塞性肺疾病稳定期的随机对照双盲试验 被引量:9
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作者 王月花 宋昱晨 +1 位作者 赵美芳 沈香娣 《中国临床药理学与治疗学》 CAS CSCD 2015年第11期1283-1286,共4页
目的:研究福多司坦胶囊对慢性阻塞性肺疾病稳定期的咳嗽咳痰症状的治疗作用及安全性。方法:将70名慢性阻塞性肺疾病稳定期患者随机分为2组:福多司坦组和氨溴索组(n=35)。福多司坦组给予福多司坦胶囊与安慰剂片剂,氨溴索组给予氨溴索片... 目的:研究福多司坦胶囊对慢性阻塞性肺疾病稳定期的咳嗽咳痰症状的治疗作用及安全性。方法:将70名慢性阻塞性肺疾病稳定期患者随机分为2组:福多司坦组和氨溴索组(n=35)。福多司坦组给予福多司坦胶囊与安慰剂片剂,氨溴索组给予氨溴索片与安慰剂胶囊。治疗28 do观察受试者日间咳嗽、夜间咳嗽、24 h痰量、痰液黏稠度、肺部啰音。结果:两组的日间咳嗽、夜间咳嗽24 h痰量、肺部啰音、临床综合疗效无统计学差异,痰液黏稠度积分有统计学差异(P<0.05)。两组的不良反应无统计学差异(6.25%vs 9.38%)。结论:福多司坦胶囊治疗慢性阻塞性肺疾病稳定期有良好的疗效及安全性。 展开更多
关键词 福多司坦 氨溴索 慢性阻塞性肺疾病 随机 双盲
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用ASP和SQL Server 2000开发在线考试系统 被引量:4
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作者 王读祥 《电脑知识与技术》 2009年第1X期525-526,534,共3页
利用ASP和SQL Server 2000研究开发的在线考试系统,它操作简单、使用方便、效率很高,具有试题的录入、修改功能,实现自动组卷以及进行在线考试等重要功能,也就是说实现了真正的无纸化考试,满足任何授权的考生随时随地考试并迅速获得成绩... 利用ASP和SQL Server 2000研究开发的在线考试系统,它操作简单、使用方便、效率很高,具有试题的录入、修改功能,实现自动组卷以及进行在线考试等重要功能,也就是说实现了真正的无纸化考试,满足任何授权的考生随时随地考试并迅速获得成绩,同时也大大减轻了教师出题、组卷和改卷等繁重的工作量。 展开更多
关键词 ASP SQL 在线考试 randomize 代码
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Systematic Review on Randomized Controlled Clinical Trials of Acupuncture Therapy for Neurovascular Headache 被引量:2
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作者 赵磊 郭义 +1 位作者 王卫 阎丽娟 《Chinese Journal of Integrative Medicine》 SCIE CAS 2011年第8期580-586,共7页
Objective:To evaluate the effectiveness of acupuncture as a treatment for neurovascular headache and to analyze the current situation related to acupuncture treatment.Methods:PubMed database (1966-2010),EMBASE dat... Objective:To evaluate the effectiveness of acupuncture as a treatment for neurovascular headache and to analyze the current situation related to acupuncture treatment.Methods:PubMed database (1966-2010),EMBASE database(1986-2010),Cochrane Library(Issue 1,2010),Chinese Biomedical Literature Database(1979-2010),China HowNet Knowledge Database(1979-2010),VIP Journals Database(1989-2010), and Wanfang database(1998-2010) were retrieved.Randomized or quasi-randomized controlled studies were included.The priority was given to high-quality randomized,controlled trials.Statistical outcome indicators were measured using RevMan 5.0.20 software.Results:A total of 16 articles and 1 535 cases were included. Meta-analysis showed a significant difference between the acupuncture therapy and Western medicine therapy [combined RR(random efficacy model)=1.46,95%CI(1.21,1.75),Z=3.96,P0.0001],indicating an obvious superior effect of the acupuncture therapy;significant difference also existed between the comprehensive acupuncture therapy and acupuncture therapy alone[combined RR(fixed efficacy model)=3.35,95%CI (1.92,5.82),Z=4.28,P0.0001],indicating that acupuncture combined with other therapies,such as points injection,scalp acupuncture,auricular acupuncture,etc.,were superior to the conventional body acupuncture therapy alone.Conclusions:The inclusion of limited clinical studies had verified the efficacy of acupuncture in the treatment of neurovascular headache.Although acupuncture or its combined therapies provides certain advantages,most clinical studies are of small sample sizes.Large sample size,randomized,controlled trials are needed in the future for more definitive results. 展开更多
关键词 neurovascular headache ACUPUNCTURE randomize controlled trials systematic review
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How random are matrix elements of the nuclear shell model Hamiltonian? 被引量:1
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作者 SHEN JiaJie1 & ZHAO YuMing1,2,3,4 1 Department of Physics,Shanghai Jiao Tong University,Shanghai 200240,China 2 Center of Theoretical Nuclear Physics,National Laboratory of Heavy Ion Accelerator,Lanzhou 730000,China +1 位作者 3 Nishina Center,Institute of Physical Chemical Research(RIKEN),Hirosawa 2-1,Wako-shi,Saitama 351-0198,Japan 4 CCAST,World Laboratory,Beijing 100080,China 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS 2009年第10期1477-1481,共5页
In this paper we study the general behavior of matrix elements of the nuclear shell model Hamiltonian.We find that nonzero off-diagonal elements exhibit a regular pattern,if one sorts the diagonal matrix elements from... In this paper we study the general behavior of matrix elements of the nuclear shell model Hamiltonian.We find that nonzero off-diagonal elements exhibit a regular pattern,if one sorts the diagonal matrix elements from smaller to larger values.The correlation between eigenvalues and diagonal matrix elements for the shell model Hamiltonian is more remarkable than that for random matrices with the same distribution unless the dimension is small. 展开更多
关键词 NUCLEAR SHELL model GEOMETRY PROPERTY linear CORRELATION randomize
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Reduced incidence and mortality from colorectal cancer with flexible-sigmoidoscopy screening: A meta-analysis 被引量:3
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作者 Jennifer Shroff Nirav Thosani +2 位作者 Sachin Batra Harminder Singh Sushovan Guha 《World Journal of Gastroenterology》 SCIE CAS 2014年第48期18466-18476,共11页
AIM: To conduct a systematic review and meta-analysis of published population-based randomized controlled trials (RCTs).
关键词 Colorectal Cancer Flexible sigmoidoscopy randomized control trials META-ANALYSIS MORTALITY INCIDENCE
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Napier Grass Rumen Degradability in Sacco in Goats (<i>Capra hircus aegagrus</i>) Supplemented with Different Sources and Amount of Dietary Fats
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作者 Niel L. Ningal 《Journal of Agricultural Chemistry and Environment》 2020年第3期177-194,共18页
The study aimed to explore the potential of dietary fats supplementation on the overall goat performance. Three (3) mature rumen-cannulated goats weighting 27.33 ± 1.53 kg housed in individual elevated metabolism... The study aimed to explore the potential of dietary fats supplementation on the overall goat performance. Three (3) mature rumen-cannulated goats weighting 27.33 ± 1.53 kg housed in individual elevated metabolism stalls with customized fecal and urine collection tools with treatments replicated three times over time following the Complete Randomized Design (CRD). Animal</span><span style="font-family:Verdana;font-size:12px;">s</span><span style="font-family:Verdana;font-size:12px;"> were randomly selected on different dietary treatment at different cycle. For each cycle, animals were provided with 30% concentrate on the morning based on feed requirements {3% of their body weight (BW) dry matter (DM) basis} of the animals. Ad libitum feeding of Napier grass will follow thereafter. Clean drinking water were made available all the times in the respective animal watering troughs. The rumen-cannulated goats were supplemented with different levels of two dietary fats (VCO and Lard) with dietary treatment combinations as follows, Control and VCO and Lard at 3% & 5%. Degradability of dry matter (DM), crude protein (CP), neutral detergent fiber (NDF) and acid detergent fiber (ADF) were collected sequentially in every cycle of the study. There were seven (7) days lag period in every cycle for the animals to return to each natural state. On the 8th day of every cycle, animals were given different dietary treatment. Sequential insertion of nylon bag was done on the 15th to</span><span style="font-family:""> </span><span style="font-family:Verdana;font-size:12px;">16th day (7 days after treatment). The results showed that degradability of the dry matter (DM) was noticed degraded exponentially on the first twelve hours of incubation and slower down </span><span style="font-family:Verdana;font-size:12px;">i</span><span style="font-family:Verdana;font-size:12px;">n the next few hours until 48 hours. Crude protein, acid and neutral detergent fiber showed breakdown of components was observed </span><span style="font-family:Verdan 展开更多
关键词 Dietary Fats Detergent Fiber Degradability Complete randomize Design Napier Grass VCO LARD Los Baños Laguna Philippines
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OBSERVATION OF REMOTE AND RECENT THERAPEUTIC EFFECTS OF ACUPOINT-THREAD EMBEDDING, WESTERN MEDICINE OR ALLIED THERAPY ON PERENNIAL ALLERGIC RHINITIS
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作者 张世平 陈丽仪 +2 位作者 罗瑞莲 郭元琦 吴文毅 《World Journal of Acupuncture-Moxibustion》 2006年第3期13-18,共6页
Objective: The comparison of the remote and recent therapeutic effects on perennial allergic rhinitis was carried on among single application of acupoint-thread embedding, western medicine (certirizine+flixonase) and ... Objective: The comparison of the remote and recent therapeutic effects on perennial allergic rhinitis was carried on among single application of acupoint-thread embedding, western medicine (certirizine+flixonase) and allied therapy. Method: Ninety cases were randomized into thread-embedding group, western medicine group and embedding+western medicine group (allied-therapy group), 30 cases in each one. In thread embedding group, Yingxiang (迎香 LI 20) and Feishu (肺俞 BL 13) were selected for thread embedding, once a week, totally 4 treatments were required. In western medicine group, certirizine tablet 10 mg in combination with flixonase sprayer was applied once per day, continuously for 30 days in treatment. In allied-therapy group, both of the above methods were adopted continuously for 30 days in treatment. The therapeutic effects were in statistics at the end of treatment and 1 year later. Results: At the end of treatment, in thread-embedding group, 21 cases were remarkably effective, 3 cases effective and 6 cases no effect. In western medicine group, 20 cases were remarkably effective, 3 cases effective and 7 cases no effect. In allied-therapy group, 23 cases were remarkably effective, 2 cases effective and 5 cases no effect. It was shown in statistics that there was no significant difference in therapeutic effects among three groups ( P>0.05 ). But one year after the end of treatment, it was indicated that in thread-embedding group, 3 cases were remarkably effective, 10 cases effective and 17 cases no effect; in western medicine group, 2 cases were remarkably effective, 9 cases effective and 19 cases no effect; in allied-therapy group, 7 cases were remarkably effective, 11 cases effective and 12 cases no effect. The significant difference in the therapeutic effects had not been presented in the comparison between thread-embedding group and western medicine group (P>0.05), but that had been presented between allied-therapy group with either of the groups with single therapy applied (P<0.05). Conclusion: 展开更多
关键词 RHINITIS ALLERGIC PERENNIAL THREAD EMBEDDING randomize
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Electroacupuncture for Treating Prostatic Hyperplasia: A Randomized Controlled Trial 被引量:2
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作者 金泽 姜珊珊 +1 位作者 包大鹏 洪珏 《Journal of Acupuncture and Tuina Science》 2011年第4期241-244,共4页
Objective: To assess the clinical effect of electroacupuncture for treating prostatic hyperplasia. Methods: Sixty patients with prostatic hyperplasia were randomized into a treatment group and a control group, 30 in... Objective: To assess the clinical effect of electroacupuncture for treating prostatic hyperplasia. Methods: Sixty patients with prostatic hyperplasia were randomized into a treatment group and a control group, 30 in each. The treatment group was treated by electroacupuncture, and the control was prescribed with orally taken Jing Zhu Qian Lie Long Bi Tong Capsule. After treatment, the two groups were compared with each other in terms of treatment result, international prostate symptom score (I-PSS), quality of life index (QLI), maximum flow rate (Qmax), and residual urine volume (RUV). Results: The total effective rate was 96.7% in the treatment group versus 70.0% in the control, and the difference was significant (P0.05). Both groups had marked improvement in I-PSS, QLI score, Qmax and RUV (P0.05). Conclusion: By improving I-PSS, QLI, Qmax and RUV, electroacupuncture is an effective way for treating prostatic hyperplasia. 展开更多
关键词 ELECTROACUPUNCTURE Acupuncture Therapy Prostatic Hyperplasia Difficulty in Urination randomize Controlled Tiral
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基于统计的浏览器指纹采集技术 被引量:2
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作者 张良峰 汪毅 +1 位作者 吴源燚 孔睿 《信息网络安全》 CSCD 北大核心 2019年第11期49-55,共7页
浏览器指纹是一项识别用户浏览器的新技术,它能够通过用户使用浏览器的各种独一无二的特征来区别不同用户并标记。浏览器指纹可以被用于广告营销和对抗网络诈骗,同时也可以被攻击者用来跟踪用户。为了保护用户隐私安全,研究者们提出了... 浏览器指纹是一项识别用户浏览器的新技术,它能够通过用户使用浏览器的各种独一无二的特征来区别不同用户并标记。浏览器指纹可以被用于广告营销和对抗网络诈骗,同时也可以被攻击者用来跟踪用户。为了保护用户隐私安全,研究者们提出了多种解决方案来避免用户被跟踪。最新的防御方法是在不影响用户使用的前提下,对浏览器指纹中的关键属性随机化,破坏用户不同会话间的关联性。针对这样的防御方法,为了能够准确得到用户浏览器指纹,文章采用了统计和侧信道攻击的方法,并根据观察所得的浏览器指纹关键属性的随机值,还原出了浏览器指纹中关键属性的真实值,从而达到区分和跟踪用户的目的。实验结果表明,该方法还原浏览器指纹的精确度超过了98%。 展开更多
关键词 浏览器隐私 设备指纹 侧信道攻击 随机化 假设检验
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信息安全在数据挖掘中的应用 被引量:1
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作者 吕品 孙宝林 《微机发展》 2005年第10期4-5,25,共3页
隐私保密是数据挖掘应用中正迅速发展的研究领域。重点讨论了数据保密的两种方法:值—类成员关系、值变形,并在此基础上给出了保密程度量化的确定。数据挖掘的任务是研究并提出整合数据的模型,文中利用贝叶斯规则重构数据的原始分布,并... 隐私保密是数据挖掘应用中正迅速发展的研究领域。重点讨论了数据保密的两种方法:值—类成员关系、值变形,并在此基础上给出了保密程度量化的确定。数据挖掘的任务是研究并提出整合数据的模型,文中利用贝叶斯规则重构数据的原始分布,并将此方法应用于决策树的生成,得到了3种构建决策树的算法:全局算法、分类算法、局部算法,并且通过理论分析得出局部算法和分类算法比全局算法的效率高。 展开更多
关键词 数据挖掘 随机化 重构
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Comment on “Outcomes of different minimally invasive surgical treatments for vertebral compression fractures: An observational study”
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作者 Long Ma Zhi-Wen Luo Ya-Ying Sun 《World Journal of Clinical Cases》 SCIE 2022年第12期3966-3968,共3页
Recently we read the article entitled“Outcomes of different minimally invasive surgical treatments for vertebral compression fractures:An observational study”.This was an observational study that reviewed the safety... Recently we read the article entitled“Outcomes of different minimally invasive surgical treatments for vertebral compression fractures:An observational study”.This was an observational study that reviewed the safety and efficacy of different cement augmentation modalities for vertebral compression fractures under osteoporotic condition.Overall,this is a valuable study that can provide a reference for clinical practice.On the other hand,we also noticed some points in the article and are willing to share our views.Further studies with a higher level of evidence can add more knowledge regarding relevant concerns. 展开更多
关键词 Vertebral compression fractures OSTEOPOROSIS Study design Observational study randomize
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Randomized controlled trials on Roy adaptation model nursing in patients with acute myocardial infarction in china: a systematic review 被引量:1
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作者 Guang-Hong Han Xiao-Li Pang Wei-Jie Gao 《Aging Communications》 2021年第4期1-5,共5页
Objective:This study was to evaluate the quality of the randomized controlled trials on Roy adaptation model nursing in individuals suffering from acute myocardial infarction in China.Methods:We systematically searche... Objective:This study was to evaluate the quality of the randomized controlled trials on Roy adaptation model nursing in individuals suffering from acute myocardial infarction in China.Methods:We systematically searched the Cnki,Wanfang and Vipdatabases,to get randomized controlled trials on Roy adaptation model nursing in individuals suffering from acute myocardial infarction.The search period was from inception to October 2020.According to the Cochrane risk bias assessment tool,the quality of the studies included was appraised.Results:A total of 55 studies were retrieved,and 11 were eventually included in the study.Among the studies included,the first study was published in 2008.The overall quality of the 11 studies included was relatively low.Conclusions:The overall quality of the randomized controlled trials on Roy adaptation model nursing in individuals suffering from acute myocardial infarction was not high,which would hinder the evidence transformation as well as clinical practice. 展开更多
关键词 Acute myocardial infarction Roy adaptation model Systematic review randomize controlled trial NURSING
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基于OVM架构的网络数据包随机序列构建与产生 被引量:1
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作者 蔡金池 《电脑知识与技术》 2010年第12期9678-9680,9683,共4页
文章根据集成电路验证的发展趋势,分析了定向测试对于日益复杂的集成电路验证的局限性,以及随机化激励测试的优点。并且基于OVM架构设计了网络数据包的随机化激励产生环境,该环境可重用性强,并且易于配置。
关键词 验证 随机化 覆盖率 OVM 数据包
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Securing acoustics-based short-range communication systems:an overview
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作者 CHEN Si QIN Zhan +1 位作者 XING Guoliang REN Kui 《Journal of Communications and Information Networks》 2016年第4期44-51,共8页
Mobile devices such as smartphones and tablets have continued to grow in recent years.Nowadays,people rely on these ubiquitous smart devices and carry them everywhere in their daily lives.Acoustic signal,as a simple a... Mobile devices such as smartphones and tablets have continued to grow in recent years.Nowadays,people rely on these ubiquitous smart devices and carry them everywhere in their daily lives.Acoustic signal,as a simple and prevalent transmitting vector for end-to-end communication,shows unique characteristics comparing with another popular communication method,i.e.,optical signal,especially on the applications performed over smart devices.Acoustic signal does not require line-of-sight when transmission,the computational power of most smart devices are sufficient to modulate/demodulate acoustic signal using software acoustic modem only,which can be easily deployed on current off-the-shelf smart devices.Therefore,many acoustics-based short range communication systems have been developed and are used in sensitive applications such as building access control and mobile payment system.However,past work shows that an acoustic eavesdropper snooping on the communication between a transmitter and its legitimate receiver can easily break their communication protocol and decode the transmitted information.To solve this problem,many solutions have been proposed to protect the acoustic signal against eavesdroppers.In this overview,we explore the designs of existing solutions,the corresponding implementations,and their methodologies to protect acoustic signal communication.For each dependable and secure acoustics-based short range communication system,we present the major technical hurdles to be overcome,the state-of-the-art,and also offer a vision of the future research issues on this promising technology. 展开更多
关键词 ACOUSTIC EAVESDROPPER short-range communication ICA BSS randomize channel motion source usability
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如何才能设计完美的临床试验?
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作者 陈苏宁 文爱东 张健 《医学争鸣》 CAS 北大核心 2011年第1期18-21,共4页
规范的随机化临床试验目前已成为制定各种疾病诊疗指南的主要依据,但治疗方案的有效与否不仅与治疗方法有关,还取决于临床试验设计的完善性。2009年4月《美国医学会杂志》(JAMA)刊登了一篇有关认知行为疗法对早期的老年性广泛性焦虑症... 规范的随机化临床试验目前已成为制定各种疾病诊疗指南的主要依据,但治疗方案的有效与否不仅与治疗方法有关,还取决于临床试验设计的完善性。2009年4月《美国医学会杂志》(JAMA)刊登了一篇有关认知行为疗法对早期的老年性广泛性焦虑症患者疗效的分析报告。我们经过仔细研读后,对影响治疗结果的主要因素进行了分析总结,指出了其在临床试验设计上存在的缺陷,我们的观点得到了编辑部和作者的认可,由此撰写的Letter发表于2009年8月的《JAMA》上。 展开更多
关键词 随机化 临床试验 心理治疗 焦虑症
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近似正态分布资料的快速测验法
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作者 韩承伟 《内蒙古农牧学院学报》 1989年第1期91-98,共8页
科研人员拥有大量的小样本试验资料,只要其具备近似正态分布的特性,采用Pullai,k,c.s.Buenaventra表。A.R;lord,E;Dixon,W.J.提出的快速测验法和相应统计用麦,进行显著性测验,其结果与一般的方差分析法基本一致,而快速测验法。具有计算... 科研人员拥有大量的小样本试验资料,只要其具备近似正态分布的特性,采用Pullai,k,c.s.Buenaventra表。A.R;lord,E;Dixon,W.J.提出的快速测验法和相应统计用麦,进行显著性测验,其结果与一般的方差分析法基本一致,而快速测验法。具有计算量小,简便快速,不易犯一类推断错误和容易掌握的优点,因此值得推广和应用。 展开更多
关键词 近似正态分布 测验法 农业统计
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VMCP方案与MP方案治疗多发性骨髓瘤临床效果的比较
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作者 徐才刚 吴俣 +1 位作者 朱焕玲 刘霆 《华西医学》 CAS 2003年第3期343-344,共2页
目的 :比较VMCP与MP方案治疗多发性骨髓瘤的疗效及副作用。方法 :4 9例多发性骨髓瘤患者随机分为两组 ,分别采用VMCP和MP方案化疗 6~ 10疗程后全面评价其疗效及副反应 ,用STATA5 0完成两组资料的X2 检验。结果 :2例患者因发生感染自... 目的 :比较VMCP与MP方案治疗多发性骨髓瘤的疗效及副作用。方法 :4 9例多发性骨髓瘤患者随机分为两组 ,分别采用VMCP和MP方案化疗 6~ 10疗程后全面评价其疗效及副反应 ,用STATA5 0完成两组资料的X2 检验。结果 :2例患者因发生感染自动出院、治疗未满 6个疗程不纳入统计 ,有 4 7例病人可供分析。VMCP组总有效率 87 5 %、治疗后平均开始显效疗程数 4疗程 ,MP组总有效率 6 9 6 %、治疗后平均开始显效疗程数 6 12 5疗程 ,两组比较有统计学意义 (P值分别小于 0 0 0 1和 0 0 1)。VMCP组和MP组出现中性粒细胞、血小板下降及发生感染情况无差异。VMCP组患者骨痛缓解情况明显优于MP组 (P <0 0 0 1)。结论 :VMCP方案疗效好、起效快、无严重副反应 。 展开更多
关键词 VMCP方案 MP方案 治疗 多发性骨髓瘤
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