利用双偏振天气雷达对2016年4月26日清远地区一次超级单体降雹进行分析,得出降雹单体具有BWER、三体散射特征。超级单体强回波中心深厚且回波顶高,速度图上低层深厚持久的中气旋和高层强烈辐散是此次过程主要特征。单体降雹前低层ZDR值...利用双偏振天气雷达对2016年4月26日清远地区一次超级单体降雹进行分析,得出降雹单体具有BWER、三体散射特征。超级单体强回波中心深厚且回波顶高,速度图上低层深厚持久的中气旋和高层强烈辐散是此次过程主要特征。单体降雹前低层ZDR值在3 d B以上,降雹时ZDR值趋近于0并且0值区范围扩大;差分相移率KDP和相关系数CC特征表明同一层面上单体存在着雹水共存、干冰雹粒子、大冰雹三种状态,冰雹下落过程中表面层融化形成水膜使差分相移率值增大。HCL特征显示HA区与指状回波对应,对流云前端有BD区。降雹单体内雹区深厚,4 km以下雹区周边以过冷却水滴为主,4 km以上为冰粒。超级单体的VIL值有2次明显的跃增过程,第1个跃增过程对应单体开始降雹,第2次过程对应大范围降雹。展开更多
Objective To evaluate the clinical efficacy and safety of Zhenzhu Qingyuan Granules through a clinical randomized controlled trial and to analyze the potential action targets and pathways of this formula using network...Objective To evaluate the clinical efficacy and safety of Zhenzhu Qingyuan Granules through a clinical randomized controlled trial and to analyze the potential action targets and pathways of this formula using network pharmacology.Methods Patients with gastroesophageal reflux disease(GERD)of liver–stomach stagnant heat pattern who met the inclusion and exclusion criteria were randomly divided into the control group and the observation group.The control group received oral rabeprazole,whereas the observation group were given Zhenzhu Qingyuan Granules in addition to the rabeprazole.The treatment duration was 8 weeks.Clinical efficacy was observed in both groups after 8 weeks.Network pharmacology was used to analyze the action targets of ZhenzhuQingyuanGranules and the genes related to GERD,and core targets were inferred.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted to explore the potential mechanisms of this formula.Results The clinical research results showed that the total effective rate in the treatment group was 92.68%,compared with 70.00%in the control group,with a statistically significant difference(p<0.05).After treatment,both Chinese medicine syndrome score and endoscopic score improved in both groups compared with before treatment(p<0.05),and the treatment group showed greater improvement than the control group(p<0.05).Network pharmacology identified effective components of Zhenzhu Qingyuan Granules for treating GERD,including quercetin,luteolin,andβ-sitosterol,with potential action targets such as tumor protein 53(TP53),protein kinase B(AKT1),and tumor necrosis factor.Conclusion Zhenzhu Qingyuan Granules can significantly improve clinical symptoms in patients with GERD of liver–stomach stagnated heat pattern,enhance clinical efficacy,and have high safety.This formula may exert therapeutic effects through multiple targets and pathways.展开更多
利用清远7个气象观测站的1957—2010年历史气象资料和NCEP/NCAR 2.5°×2.5°再分析资料,对影响清远热带气旋(TC)的气候特征及其成因进行分析。结果表明:TC影响异常偏多年份,7—9月200 h Pa南亚高压偏强,高空辐散的抽吸作...利用清远7个气象观测站的1957—2010年历史气象资料和NCEP/NCAR 2.5°×2.5°再分析资料,对影响清远热带气旋(TC)的气候特征及其成因进行分析。结果表明:TC影响异常偏多年份,7—9月200 h Pa南亚高压偏强,高空辐散的抽吸作用对登陆台风低压的垂直运动和低空辐合上升运动有正贡献;500 h Pa副高主体呈带状,TC受副热带高压南侧东南气流操纵,向西北方向移动,常在广东沿海登陆;850 h Pa西南季风强盛,中低层的水汽输送明显增加,从而使台风低压环流在陆上维持或强度减弱缓慢。无TC影响年份500 h Pa副高呈方块状,面积宽广,南海和西太平洋受副热带高压控制,不利于TC生成。展开更多
利用MTSAT卫星云图、广州雷达资料、Micaps常规气象观测资料、NCEP再分析资料以及ECMWF资料对2014年5月23日中尺度对流云团静止在清远市上空停滞不前,导致清远市出现12 h左右持续性的强降水过程进行分析。结果表明:500 h Pa上出现的阻...利用MTSAT卫星云图、广州雷达资料、Micaps常规气象观测资料、NCEP再分析资料以及ECMWF资料对2014年5月23日中尺度对流云团静止在清远市上空停滞不前,导致清远市出现12 h左右持续性的强降水过程进行分析。结果表明:500 h Pa上出现的阻塞形势,外加加强西伸的副热带高压阻挡是导致中尺度雨团出现"准静止"的主要原因;地面明显的地转偏差造成的辐合作用是触发该次过程中尺度对流云团形成和发展的关键因素;另外清远肇庆交界的山脉对西南面暖湿气流的辐合抬升作用、对东面雷暴高压流出气流的阻挡作用利于形成一条类似于准静止锋的准静止飑线,也是中尺度雨团出现"准静止"的原因之一。展开更多
文摘利用双偏振天气雷达对2016年4月26日清远地区一次超级单体降雹进行分析,得出降雹单体具有BWER、三体散射特征。超级单体强回波中心深厚且回波顶高,速度图上低层深厚持久的中气旋和高层强烈辐散是此次过程主要特征。单体降雹前低层ZDR值在3 d B以上,降雹时ZDR值趋近于0并且0值区范围扩大;差分相移率KDP和相关系数CC特征表明同一层面上单体存在着雹水共存、干冰雹粒子、大冰雹三种状态,冰雹下落过程中表面层融化形成水膜使差分相移率值增大。HCL特征显示HA区与指状回波对应,对流云前端有BD区。降雹单体内雹区深厚,4 km以下雹区周边以过冷却水滴为主,4 km以上为冰粒。超级单体的VIL值有2次明显的跃增过程,第1个跃增过程对应单体开始降雹,第2次过程对应大范围降雹。
基金National Administration of Traditional Chinese Medicine Evidence-Based Capacity Building Project(2019XZZXXH005)Special Project on Traditional Chinese Medicine Scientific Research of Health Commission of Henan Province(2022ZY2022)+1 种基金Henan Provincial Top Talents Cultivation Project in Traditional Chinese Medicine Discipline of Henan Provincial Traditional Chinese Medicine Inheritance and Innovation Talents Project(Zhongjing Project)(Henan Health TraditionalMedicine Letter[2021]No.15)Special Project on Traditional Chinese Medicine Scientific Research of Health Commission of Henan Province(2023ZY2062).
文摘Objective To evaluate the clinical efficacy and safety of Zhenzhu Qingyuan Granules through a clinical randomized controlled trial and to analyze the potential action targets and pathways of this formula using network pharmacology.Methods Patients with gastroesophageal reflux disease(GERD)of liver–stomach stagnant heat pattern who met the inclusion and exclusion criteria were randomly divided into the control group and the observation group.The control group received oral rabeprazole,whereas the observation group were given Zhenzhu Qingyuan Granules in addition to the rabeprazole.The treatment duration was 8 weeks.Clinical efficacy was observed in both groups after 8 weeks.Network pharmacology was used to analyze the action targets of ZhenzhuQingyuanGranules and the genes related to GERD,and core targets were inferred.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted to explore the potential mechanisms of this formula.Results The clinical research results showed that the total effective rate in the treatment group was 92.68%,compared with 70.00%in the control group,with a statistically significant difference(p<0.05).After treatment,both Chinese medicine syndrome score and endoscopic score improved in both groups compared with before treatment(p<0.05),and the treatment group showed greater improvement than the control group(p<0.05).Network pharmacology identified effective components of Zhenzhu Qingyuan Granules for treating GERD,including quercetin,luteolin,andβ-sitosterol,with potential action targets such as tumor protein 53(TP53),protein kinase B(AKT1),and tumor necrosis factor.Conclusion Zhenzhu Qingyuan Granules can significantly improve clinical symptoms in patients with GERD of liver–stomach stagnated heat pattern,enhance clinical efficacy,and have high safety.This formula may exert therapeutic effects through multiple targets and pathways.
文摘利用清远7个气象观测站的1957—2010年历史气象资料和NCEP/NCAR 2.5°×2.5°再分析资料,对影响清远热带气旋(TC)的气候特征及其成因进行分析。结果表明:TC影响异常偏多年份,7—9月200 h Pa南亚高压偏强,高空辐散的抽吸作用对登陆台风低压的垂直运动和低空辐合上升运动有正贡献;500 h Pa副高主体呈带状,TC受副热带高压南侧东南气流操纵,向西北方向移动,常在广东沿海登陆;850 h Pa西南季风强盛,中低层的水汽输送明显增加,从而使台风低压环流在陆上维持或强度减弱缓慢。无TC影响年份500 h Pa副高呈方块状,面积宽广,南海和西太平洋受副热带高压控制,不利于TC生成。
文摘利用MTSAT卫星云图、广州雷达资料、Micaps常规气象观测资料、NCEP再分析资料以及ECMWF资料对2014年5月23日中尺度对流云团静止在清远市上空停滞不前,导致清远市出现12 h左右持续性的强降水过程进行分析。结果表明:500 h Pa上出现的阻塞形势,外加加强西伸的副热带高压阻挡是导致中尺度雨团出现"准静止"的主要原因;地面明显的地转偏差造成的辐合作用是触发该次过程中尺度对流云团形成和发展的关键因素;另外清远肇庆交界的山脉对西南面暖湿气流的辐合抬升作用、对东面雷暴高压流出气流的阻挡作用利于形成一条类似于准静止锋的准静止飑线,也是中尺度雨团出现"准静止"的原因之一。
