This study is aimed to assess the long-term healthrelated quality of life （HRQL） of patients after esophagectomy for esophageal cancer in comparison with established norms, and to evaluate changes in HRQL during the...This study is aimed to assess the long-term healthrelated quality of life （HRQL） of patients after esophagectomy for esophageal cancer in comparison with established norms, and to evaluate changes in HRQL during the different stages of follow-up after esophageal resection. A systematic review was performed by searching medical databases （Medline, Embase and the Cochrane Library） for potentially relevant studies that appeared between January 1975 and March 2011. Studies were included if they addressed the question of HRQL after esophageal resection for esophageal cancer. Two researchers independently performed the study selection, data extraction and analysis processes. Twenty-one observational studies were included with a total of 1282 （12-355） patients. Five studies were performed with short form-36 （SF-36） and 16 with European Organization for Research and Treatment of Cancer （EORTC） QLQ c30 （14 of them also utilized the disease-specific OESI8 or its previous version OES24）.The analysis of long-term generic HRQL with SF-36 showed pooled scores for physical, role and social function after esophagectomy similar to United States norms, but lower pooled scores for physical function, vitality and general health perception. The analysis of HRQL conducted using the Global EORTC C30 global scale during a 6-mo follow-up showed that global scale and physical function were better at the baseline. The symptom scales indicated worsened fatigue, dyspnea and diarrhea 6 mo after esophagectomy. In contrast, however, emotional function had significantly improved after 6 mo. In conclusion, short- and long-term HRQL is deeply affected after esophagectomy for cancer. The impairment of physical function may be a long-term consequence of esophagectomy involving either the respiratory system or the alimentary tract. The short- and long-term improvement in the emotional function of patients who have undergone successful operations may be attributed to the impression that they have survived a near-death experienc展开更多
目的:观察膀胱癌患者行根治性膀胱切除回肠膀胱术、原位回肠代膀胱术术后生活质量。方法:采用癌症患者生活质量核心问卷(EORTC QLQ-C30 Version 3中文版),分别对35例回肠膀胱术和25例原位回肠代膀胱术术后患者生活质量进行调查。结果:...目的:观察膀胱癌患者行根治性膀胱切除回肠膀胱术、原位回肠代膀胱术术后生活质量。方法:采用癌症患者生活质量核心问卷(EORTC QLQ-C30 Version 3中文版),分别对35例回肠膀胱术和25例原位回肠代膀胱术术后患者生活质量进行调查。结果:回肠膀胱术和原位回肠代膀胱术,两种不同术式对膀胱癌术后患者总体生活质量的影响无明显差别(P>0.05),而对膀胱癌术后患者躯体功能、角色功能、情绪功能、社会功能方面的影响存在显著性差异(P<0.05)。结论:在临床医疗工作中应充分考虑到影响患者生活质量的各种因素,根据患者的具体情况,为其提供有效的干预措施,提高患者术后生活质量。展开更多
Objective: The aims of this cross-sectional descriptive study were to evaluate the quality of life (QoL) of the lung cancer patients and to investigate differences in QoL with respect to general and medical characteri...Objective: The aims of this cross-sectional descriptive study were to evaluate the quality of life (QoL) of the lung cancer patients and to investigate differences in QoL with respect to general and medical characteristics. Methods: Structured questionnaires (EORTC QLQ-C30 and QLQ-LC13) were used among 106 consecutive lung cancer patients for data collection during 1 Jan 2002 to 31 Dec 2002. The t-test and one-way analysis of variance (ANOVA) were used to compare differences of QoL between the factors at a 5% level of significance. Results: The study revealed that the quality of life of the lung cancer patients were worse than reference value. The young, male and married patient groups had better QoL. Patients with lower education or income had worse QoL. Small cell lung cancer patients reported poorer QoL than non-small cell lung cancer patients. The quality of life in patients at late stage or with metastasis had worse QoL. The treatments could worsen the quality of life. When the outcomes of the four treatments were compared, the surgery group displayed the best quality of life and the combined treatment group displayed the worst quality of life. Conclusion: The results of the present study showed important ramifications for clinicians, researchers and policy-makers.展开更多
For patients with esophageal carcinoma (ESCA), health-related quality of life (HRQoL) has now become an essential feature. To examine the quality of life of preoperative and postoperative ESCA patients, we used the Eu...For patients with esophageal carcinoma (ESCA), health-related quality of life (HRQoL) has now become an essential feature. To examine the quality of life of preoperative and postoperative ESCA patients, we used the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire (EORTC QLQ C-30) and the Quality of Life Questionnaire Oesophageal 18 (QLQ-OES18). Using the EORTC QLQ-C30 and the QLQ-OES18 questionnaire, the analysis of the quality of life scores of 246 patients with oesophageal cancer who were operated on at the Sun Yat-sen University Cancer Centre during the period 2013 to 2015 was carried out. Differences between pre- and post-surgical EORTC QLQ C-30 and QLQ-OES18 scores were examined using the Student’s t-test. Patients’ global health status (QoL) decreased significantly one month after the operation but gradually recovered within a year. In terms of the role function, the emotional function, the cognitive function, and the perception and function variants, EORTC QLQ-C30 and QLQ-OES18 scores increased statistically significantly, as did clinical signs variables such as exhaustion, nausea, vomiting, pain, sleeplessness, decreased appetite, stomach pain, and economic hardship. After surgery, there was an improvement in functional and symptom domains in esophageal carcinoma patients. EORTC QLQ-C30 and QLQ-OES18 can be used to assess the HRQoL before and after surgical procedures.展开更多
<strong>Background: </strong><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;">Ovarian cancer accounts for 4% of can...<strong>Background: </strong><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;">Ovarian cancer accounts for 4% of cancers occurring in women and ranks first in gynecological cancer mortality. Maintaining and improving quality of life is an important goal of cancer treatment. The toxicities of cancer treatment particularly chemotherapy can impact an individual’s wellbeing. </span><b><span style="font-family:Verdana;">Objective:</span></b><span style="font-family:Verdana;"> Assessment of quality of life among ovarian cancer patients receiving chemotherapy.</span><b><span style="font-family:Verdana;"> Method: </span></b><span style="font-family:Verdana;">A descriptive study was conducted among 202 patients with ovarian cancer treated at the National Institute of Cancer Research and Hospital in Bangladesh. Ethical approval was received from the ethics committee of NICRH. Data was collected using the EORTC QLQC30 questionnaire and the ovarian cancer specific EORTC QOL OV-28 module. Functional, symptomatic and global variables were scored and analyzed by SPSS. Multiple linear regressions determined the effects of predictor variables and correlation of the global health status with other variables. </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">48.6% </span><span style="font-family:Verdana;">of patients were ages 41 to 50 years. The mean score of global health status was</span><span style="font-family:Verdana;"> 55.77. Deteriorating emotional function, distressing physical and psychological symptoms, sexual dysfunction and financial difficulties adversely affect the quality of life. Their correlation with global health status was strongly significant (P value < 0.05). Fatigue (r value </span></span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">0.604;p < 0.05) loss of appetite (r value </span><span style="font-family:Verdana;">-</span><span style="f展开更多
文摘This study is aimed to assess the long-term healthrelated quality of life （HRQL） of patients after esophagectomy for esophageal cancer in comparison with established norms, and to evaluate changes in HRQL during the different stages of follow-up after esophageal resection. A systematic review was performed by searching medical databases （Medline, Embase and the Cochrane Library） for potentially relevant studies that appeared between January 1975 and March 2011. Studies were included if they addressed the question of HRQL after esophageal resection for esophageal cancer. Two researchers independently performed the study selection, data extraction and analysis processes. Twenty-one observational studies were included with a total of 1282 （12-355） patients. Five studies were performed with short form-36 （SF-36） and 16 with European Organization for Research and Treatment of Cancer （EORTC） QLQ c30 （14 of them also utilized the disease-specific OESI8 or its previous version OES24）.The analysis of long-term generic HRQL with SF-36 showed pooled scores for physical, role and social function after esophagectomy similar to United States norms, but lower pooled scores for physical function, vitality and general health perception. The analysis of HRQL conducted using the Global EORTC C30 global scale during a 6-mo follow-up showed that global scale and physical function were better at the baseline. The symptom scales indicated worsened fatigue, dyspnea and diarrhea 6 mo after esophagectomy. In contrast, however, emotional function had significantly improved after 6 mo. In conclusion, short- and long-term HRQL is deeply affected after esophagectomy for cancer. The impairment of physical function may be a long-term consequence of esophagectomy involving either the respiratory system or the alimentary tract. The short- and long-term improvement in the emotional function of patients who have undergone successful operations may be attributed to the impression that they have survived a near-death experienc
文摘目的:观察膀胱癌患者行根治性膀胱切除回肠膀胱术、原位回肠代膀胱术术后生活质量。方法:采用癌症患者生活质量核心问卷(EORTC QLQ-C30 Version 3中文版),分别对35例回肠膀胱术和25例原位回肠代膀胱术术后患者生活质量进行调查。结果:回肠膀胱术和原位回肠代膀胱术,两种不同术式对膀胱癌术后患者总体生活质量的影响无明显差别(P>0.05),而对膀胱癌术后患者躯体功能、角色功能、情绪功能、社会功能方面的影响存在显著性差异(P<0.05)。结论:在临床医疗工作中应充分考虑到影响患者生活质量的各种因素,根据患者的具体情况,为其提供有效的干预措施,提高患者术后生活质量。
文摘Objective: The aims of this cross-sectional descriptive study were to evaluate the quality of life (QoL) of the lung cancer patients and to investigate differences in QoL with respect to general and medical characteristics. Methods: Structured questionnaires (EORTC QLQ-C30 and QLQ-LC13) were used among 106 consecutive lung cancer patients for data collection during 1 Jan 2002 to 31 Dec 2002. The t-test and one-way analysis of variance (ANOVA) were used to compare differences of QoL between the factors at a 5% level of significance. Results: The study revealed that the quality of life of the lung cancer patients were worse than reference value. The young, male and married patient groups had better QoL. Patients with lower education or income had worse QoL. Small cell lung cancer patients reported poorer QoL than non-small cell lung cancer patients. The quality of life in patients at late stage or with metastasis had worse QoL. The treatments could worsen the quality of life. When the outcomes of the four treatments were compared, the surgery group displayed the best quality of life and the combined treatment group displayed the worst quality of life. Conclusion: The results of the present study showed important ramifications for clinicians, researchers and policy-makers.
文摘For patients with esophageal carcinoma (ESCA), health-related quality of life (HRQoL) has now become an essential feature. To examine the quality of life of preoperative and postoperative ESCA patients, we used the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire (EORTC QLQ C-30) and the Quality of Life Questionnaire Oesophageal 18 (QLQ-OES18). Using the EORTC QLQ-C30 and the QLQ-OES18 questionnaire, the analysis of the quality of life scores of 246 patients with oesophageal cancer who were operated on at the Sun Yat-sen University Cancer Centre during the period 2013 to 2015 was carried out. Differences between pre- and post-surgical EORTC QLQ C-30 and QLQ-OES18 scores were examined using the Student’s t-test. Patients’ global health status (QoL) decreased significantly one month after the operation but gradually recovered within a year. In terms of the role function, the emotional function, the cognitive function, and the perception and function variants, EORTC QLQ-C30 and QLQ-OES18 scores increased statistically significantly, as did clinical signs variables such as exhaustion, nausea, vomiting, pain, sleeplessness, decreased appetite, stomach pain, and economic hardship. After surgery, there was an improvement in functional and symptom domains in esophageal carcinoma patients. EORTC QLQ-C30 and QLQ-OES18 can be used to assess the HRQoL before and after surgical procedures.
文摘<strong>Background: </strong><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;">Ovarian cancer accounts for 4% of cancers occurring in women and ranks first in gynecological cancer mortality. Maintaining and improving quality of life is an important goal of cancer treatment. The toxicities of cancer treatment particularly chemotherapy can impact an individual’s wellbeing. </span><b><span style="font-family:Verdana;">Objective:</span></b><span style="font-family:Verdana;"> Assessment of quality of life among ovarian cancer patients receiving chemotherapy.</span><b><span style="font-family:Verdana;"> Method: </span></b><span style="font-family:Verdana;">A descriptive study was conducted among 202 patients with ovarian cancer treated at the National Institute of Cancer Research and Hospital in Bangladesh. Ethical approval was received from the ethics committee of NICRH. Data was collected using the EORTC QLQC30 questionnaire and the ovarian cancer specific EORTC QOL OV-28 module. Functional, symptomatic and global variables were scored and analyzed by SPSS. Multiple linear regressions determined the effects of predictor variables and correlation of the global health status with other variables. </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">48.6% </span><span style="font-family:Verdana;">of patients were ages 41 to 50 years. The mean score of global health status was</span><span style="font-family:Verdana;"> 55.77. Deteriorating emotional function, distressing physical and psychological symptoms, sexual dysfunction and financial difficulties adversely affect the quality of life. Their correlation with global health status was strongly significant (P value < 0.05). Fatigue (r value </span></span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">0.604;p < 0.05) loss of appetite (r value </span><span style="font-family:Verdana;">-</span><span style="f
