Pulmonary abnormalities,dysfunction or hyper-reactivity occurs in association with inflammatory bowel disease(IBD) more frequently than previously recognized.Emerging evidence suggests that subtle inflammation exists ...Pulmonary abnormalities,dysfunction or hyper-reactivity occurs in association with inflammatory bowel disease(IBD) more frequently than previously recognized.Emerging evidence suggests that subtle inflammation exists in the airways among IBD patients even in the absence of any bronchopulmonary symptoms,and with normal pulmonary functions. The pulmonary impairment is more pronounced in IBD patients with active disease than in those in remission. A growing number of case reports show that the IBD patients develop rapidly progressive respiratory symptoms after colectomy,with failure to isolate bacterial pathogens on repeated sputum culture,and often request oral corticosteroid therapy. All the above evidence indicates that the inflammatory changes in both the intestine and lung during IBD. Clinical or subclinical pulmonary inflammation accompanies the main inflammation of the bowel.Although there are clinical and epidemiological reports of chronic inflammation of the pulmonary and intestinal mucosa in IBD,the detailed mechanisms of pulmonaryintestinal crosstalk remain unknown. The lung has no anatomical connection with the main inflammatory site of the bowel. Why does the inflammatory process shift from the gastrointestinal tract to the airways? The clinical and subclinical pulmonary abnormalities,dysfunction,or hyper-reactivity among IBD patients need further evaluation. Here,we give an overview of the concordance between chronic inflammatory reactions in the airways and the gastrointestinal tract. A better understanding of the possible mechanism of the crosstalk among the distant organs will be beneficial in identifying therapeutic strategies for mucosal inflammatory diseases such as IBD and allergy.展开更多
We report neurological changes and circulatory and pulmonary symptoms after surgical intervention in cases of brainstem cavernous angioma. Eight patients who underwent surgical intervention for brainstem cavernous ang...We report neurological changes and circulatory and pulmonary symptoms after surgical intervention in cases of brainstem cavernous angioma. Eight patients who underwent surgical intervention for brainstem cavernous angiomas were retrospectively reviewed. Two of 4 patients who underwent total removal of the mass showed marked resolution of the preoperative signs including IX nerve palsy, MLF syndrome, cerebellar sign and homonymous hemianopsia, and two patients who underwent partial removal of the lesions had permanent neurological deficits. Inadequate excision results in not only recurrence of hemorrhage, but also postoperative neurological deterioration. Bradycardia can occur during the surgical intervention, and careful monitoring is mandatory for a couple of days after operation to detect circulatory and pulmonary failure such as atrial flutter.展开更多
文摘Pulmonary abnormalities,dysfunction or hyper-reactivity occurs in association with inflammatory bowel disease(IBD) more frequently than previously recognized.Emerging evidence suggests that subtle inflammation exists in the airways among IBD patients even in the absence of any bronchopulmonary symptoms,and with normal pulmonary functions. The pulmonary impairment is more pronounced in IBD patients with active disease than in those in remission. A growing number of case reports show that the IBD patients develop rapidly progressive respiratory symptoms after colectomy,with failure to isolate bacterial pathogens on repeated sputum culture,and often request oral corticosteroid therapy. All the above evidence indicates that the inflammatory changes in both the intestine and lung during IBD. Clinical or subclinical pulmonary inflammation accompanies the main inflammation of the bowel.Although there are clinical and epidemiological reports of chronic inflammation of the pulmonary and intestinal mucosa in IBD,the detailed mechanisms of pulmonaryintestinal crosstalk remain unknown. The lung has no anatomical connection with the main inflammatory site of the bowel. Why does the inflammatory process shift from the gastrointestinal tract to the airways? The clinical and subclinical pulmonary abnormalities,dysfunction,or hyper-reactivity among IBD patients need further evaluation. Here,we give an overview of the concordance between chronic inflammatory reactions in the airways and the gastrointestinal tract. A better understanding of the possible mechanism of the crosstalk among the distant organs will be beneficial in identifying therapeutic strategies for mucosal inflammatory diseases such as IBD and allergy.
文摘We report neurological changes and circulatory and pulmonary symptoms after surgical intervention in cases of brainstem cavernous angioma. Eight patients who underwent surgical intervention for brainstem cavernous angiomas were retrospectively reviewed. Two of 4 patients who underwent total removal of the mass showed marked resolution of the preoperative signs including IX nerve palsy, MLF syndrome, cerebellar sign and homonymous hemianopsia, and two patients who underwent partial removal of the lesions had permanent neurological deficits. Inadequate excision results in not only recurrence of hemorrhage, but also postoperative neurological deterioration. Bradycardia can occur during the surgical intervention, and careful monitoring is mandatory for a couple of days after operation to detect circulatory and pulmonary failure such as atrial flutter.
