Arterial stiffness has been recognized as a marker of cardiovascular disease and associated with longterm worse clinical outcomes in several populations. Age, hypertension, smoking, and dyslipidemia, known as traditio...Arterial stiffness has been recognized as a marker of cardiovascular disease and associated with longterm worse clinical outcomes in several populations. Age, hypertension, smoking, and dyslipidemia, known as traditional vascular risk factors, as well as diabetes, obesity, and systemic inflammation lead to both atherosclerosis and arterial stiffness. Targeting multiple modifiable risk factors has become the main therapeutic strategy to improve arterial stiffness in patients at high cardiovascular risk. Additionally to life style modifications, long-term ω-3 fatty acids(fish oil) supplementation in diet may improve arterial stiffness in the population with hypertension or metabolic syndrome. Pharmacological treatment such as reninangiotensin-aldosterone system antagonists, metformin, and 3-hydroxy-3-methyl-glutaryl-Co A reductase inhibitors were useful in individuals with hypertension and diabetes. In obese population with obstructive sleep apnea, weight reduction, aerobic exercise, and continuous positive airway pressure treatment may also improve arterial stiffness. In the populations with chronic inflammatory disease such as rheumatoid arthritis, a use of antibodies against tumor necrosis factor-alpha could work effectively. Other therapeutic options such as renal sympathetic nerve denervation for patients with resistant hypertension are investigated in many ongoing clinical trials. Therefore our comprehensive review provides knowledge in detail regarding many aspects of pathogenesis, measurement, and management of arterial stiffness in several populations, which would be helpful for physicians to make clinical decision.展开更多
In the test, internal inlay drip irrigation pipes with different wal thicknesses or diameters （￠at 12 mm and 16 mm） were tested under varying tension forces and it was concluded that 90 N is the rational one. What...In the test, internal inlay drip irrigation pipes with different wal thicknesses or diameters （￠at 12 mm and 16 mm） were tested under varying tension forces and it was concluded that 90 N is the rational one. What’s more, the smal er drip-irrigation inner diameter, the thinner wal thickness, and the higher tension force, the lower acceptability, and the larger drip-irrigation inner diameter, the thicker wal thickness, and the lower tension force, the higher acceptability. The causes were analyzed in the research, including manufacturing technique leading to disqualifica-tion and different specifications with the same demands on techniques, and inadap-tation to tension force at 130 N.展开更多
文摘Arterial stiffness has been recognized as a marker of cardiovascular disease and associated with longterm worse clinical outcomes in several populations. Age, hypertension, smoking, and dyslipidemia, known as traditional vascular risk factors, as well as diabetes, obesity, and systemic inflammation lead to both atherosclerosis and arterial stiffness. Targeting multiple modifiable risk factors has become the main therapeutic strategy to improve arterial stiffness in patients at high cardiovascular risk. Additionally to life style modifications, long-term ω-3 fatty acids(fish oil) supplementation in diet may improve arterial stiffness in the population with hypertension or metabolic syndrome. Pharmacological treatment such as reninangiotensin-aldosterone system antagonists, metformin, and 3-hydroxy-3-methyl-glutaryl-Co A reductase inhibitors were useful in individuals with hypertension and diabetes. In obese population with obstructive sleep apnea, weight reduction, aerobic exercise, and continuous positive airway pressure treatment may also improve arterial stiffness. In the populations with chronic inflammatory disease such as rheumatoid arthritis, a use of antibodies against tumor necrosis factor-alpha could work effectively. Other therapeutic options such as renal sympathetic nerve denervation for patients with resistant hypertension are investigated in many ongoing clinical trials. Therefore our comprehensive review provides knowledge in detail regarding many aspects of pathogenesis, measurement, and management of arterial stiffness in several populations, which would be helpful for physicians to make clinical decision.
文摘In the test, internal inlay drip irrigation pipes with different wal thicknesses or diameters （￠at 12 mm and 16 mm） were tested under varying tension forces and it was concluded that 90 N is the rational one. What’s more, the smal er drip-irrigation inner diameter, the thinner wal thickness, and the higher tension force, the lower acceptability, and the larger drip-irrigation inner diameter, the thicker wal thickness, and the lower tension force, the higher acceptability. The causes were analyzed in the research, including manufacturing technique leading to disqualifica-tion and different specifications with the same demands on techniques, and inadap-tation to tension force at 130 N.
