Objective To evaluate the reliability of three dimensional spiral fast spin echo pseudo-continuous arterial spin labeling(3 D pc-ASL) in measuring cerebral blood flow(CBF) with different post-labeling delay time(PLD) ...Objective To evaluate the reliability of three dimensional spiral fast spin echo pseudo-continuous arterial spin labeling(3 D pc-ASL) in measuring cerebral blood flow(CBF) with different post-labeling delay time(PLD) in the resting state and the right finger taping state.Methods 3 D pc-ASL and three dimensional T1-weighted fast spoiled gradient recalled echo(3 D T1-FSPGR) sequence were applied to eight healthy subjects twice at the same time each day for one week interval. ASL data acquisition was performed with post-labeling delay time(PLD) 1.5 seconds and 2.0 seconds in the resting state and the right finger taping state respectively. CBF mapping was calculated and CBF value of both the gray matter(GM) and white matter(WM) was automatically extracted. The reliability was evaluated using the intraclass correlation coefficient(ICC) and Bland and Altman plot.Results ICC of the GM(0.84) and WM(0.92) was lower at PLD 1.5 seconds than that(GM, 0.88; WM, 0.94) at PLD 2.0 seconds in the resting state, and ICC of GM(0.88) was higher in the right finger taping state than that in the resting state at PLD 1.5 seconds. ICC of the GM and WM was 0.71 and 0.78 for PLD 1.5 seconds and PLD 2.0 seconds in the resting state at the first scan, and ICC of the GM and WM was 0.83 and 0.79 at the second scan, respectively.Conclusion This work demonstrated that 3 D pc-ASL might be a reliable imaging technique to measure CBF over the whole brain at different PLD in the resting state or controlled state.展开更多
目的比较多参数三维假连续式动脉自旋标记灌注成像(3D p CASL)与动态磁敏感增强灌注成像(DSC PWI)对短暂性脑缺血发作(TIA)责任病灶的检出率。方法比较39例临床诊断TIA患者,并在首次发作24 h内进行磁共振检查。扫描序列包括常规头颅MR...目的比较多参数三维假连续式动脉自旋标记灌注成像(3D p CASL)与动态磁敏感增强灌注成像(DSC PWI)对短暂性脑缺血发作(TIA)责任病灶的检出率。方法比较39例临床诊断TIA患者,并在首次发作24 h内进行磁共振检查。扫描序列包括常规头颅MR成像、MRA(MRA),DWI、3D p CASL(选取两个标记延迟时间post-labeling time,PLD,PLD=1.5 s及PLD=2.5 s),DSC PWI。后处理获取3D p CASL的脑血流(CBF)图像和DSC PWI的Tmax图像。比较不同灌注方法与MRA及DWI结合法对于缺血病灶检出率和缺血面积。结果 TIA患者的缺血病灶检出率,3D p CASL(PLD1.5 s及PLD2.5 s)的CBF图像与DSC PWI Tmax对比无差异;3D p CASL(PLD1.5 s)的CBF图像对于缺血的检出率高于MRA结合DWI法;DSC PWI Tmax、3D p CASL(PLD2.5 s)CBF与MRA结合DWI法无差异。显示低灌注面积,3D p CASL(PLD1.5 s)的CBF图像显示的面积最大,其次是DSC PWI Tmax,而3D p CASL(PLD2.5 s)的CBF图像显示的低灌注面积最小。结论 3D p CASL脑灌注成像技术无创、快速、可重复性强,推荐作为临床可疑TIA患者的影像筛查手段,不同PLD的3D p CASL序列对于病灶的检出及缺血面积的显示有差异,选择较短PLD有可能提高病灶的检出率。展开更多
目的:探讨磁共振三维准连续动脉自旋标记(3D-pCASL)成像技术在急性缺血性脑卒中患者中临床诊断中的应用价值。方法:选择61例急性缺血性脑卒中患者,设为观察组;选择同期治疗的59例非急性缺血性脑卒中患者,设为对照组。两组均在完成常规...目的:探讨磁共振三维准连续动脉自旋标记(3D-pCASL)成像技术在急性缺血性脑卒中患者中临床诊断中的应用价值。方法:选择61例急性缺血性脑卒中患者,设为观察组;选择同期治疗的59例非急性缺血性脑卒中患者,设为对照组。两组均在完成常规磁共振弥散加权成像(DWI)及3D-pCASL检查;测量病灶及对侧镜像区域脑组织脑血流量(CBF);绘制ROC曲线,分析不同检查方法诊断效能。结果: 61例急性缺血性脑卒中患者最终均得到确诊,患者经3D-pCASL成像技术检测确诊60例,诊断符合率为98.36%( P >0.05);DWI检查确诊58例,诊断符合率95.08%( P >0.05);观察组患者健侧CBF水平与对照组比较,差异无统计学意义( P >0.05);观察组患者患侧CBF水平低于对照组( P <0.05);ROC曲线结果显示:单一DWI、3D-pCASL检查在急性缺血性脑卒中患者中的诊断特异性、敏感性均无统计学意义( P >0.05);DWI及3D-pCASL联合检查在急性缺血性脑卒中患者中的诊断特异性、敏感性,高于单一DWI、3D-pCASL检查( P <0.05)。结论:将3D-pCASL成像技术用于急性缺血性脑卒中患者中效果理想,能实现脑血流量的可视化,弥补传统DWI存在的弊端,为临床诊疗提供可靠的依据和参考。展开更多
目的分析肝性脑病(HE)患者脑血流量(CBF)的变化并探讨灌注模式。方法搜集20例经临床检查证实的HE患者和20名健康志愿者纳入本研究,采用3.0 T MRI进行三维准连续动脉自旋标记(3D-pCASL)灌注成像扫描,统计分析患者组(HE组)与正常对照组的...目的分析肝性脑病(HE)患者脑血流量(CBF)的变化并探讨灌注模式。方法搜集20例经临床检查证实的HE患者和20名健康志愿者纳入本研究,采用3.0 T MRI进行三维准连续动脉自旋标记(3D-pCASL)灌注成像扫描,统计分析患者组(HE组)与正常对照组的脑灌注差异。结果 HE组右侧尾状核头、苍白球、壳核、丘脑、扣带回CBF值分别为(55.65±16.40)、(38.63±7.62)、(52.22±9.77)、(61.31±14.05)、(82.32±16.27)ml·100g^(-1)·min^(-1),左侧尾状核头、苍白球、壳核、丘脑、扣带回CBF值分别为(56.14±17.20)、(36.89±7.94)、(49.54±10.29)、(65.32±13.76)、(84.91±17.39)ml·100g^(-1)·min^(-1),中脑及脑桥CBF值为(48.62±11.23)、(52.43±9.10)ml·100g^(-1)·min^(-1);对照组右侧尾状核头、苍白球、壳核、丘脑、扣带回CBF值分别为(56.46±5.98)、(36.41±4.76)、(45.88±5.88)、(50.27±7.42)、(51.59±6.06)ml·100g^(-1)·min^(-1),左侧尾状核头、苍白球、壳核、丘脑、扣带回CBF值分别为(57.11±9.04)、(34.08±3.92)、(45.65±7.71)、(53.40±7.79)、(55.90±8.08)ml·100g^(-1)·min^(-1),中脑及脑桥CBF值为(42.68±7.18)、(41.21±5.91)ml·100g^(-1)·min^(-1)。与对照组比较,HE组双侧丘脑、扣带回及脑桥的CBF升高,差异均具有统计学意义(P<0.05),双侧尾状核头、苍白球、壳核及中脑的CBF差异无统计学意义(P>0.05)。尾状核头的CBF值与Child-Pugh评分相关(P<0.05),双侧苍白球、壳核、丘脑、扣带回、中脑及脑桥的CBF值均与Child-Pugh评分无关(P>0.05)。结论 3D-pCASL可定量评估HE患者的CBF,HE患者皮质功能不良,CBF由皮质向基底神经节重新分配。展开更多
基金Supported by the Foundation for Medical and Health Sci&Tech Innovation Project of Sanya(2016YW37)the Special Financial Grant from China Postdoctoral Science Foundation(2014T70960)
文摘Objective To evaluate the reliability of three dimensional spiral fast spin echo pseudo-continuous arterial spin labeling(3 D pc-ASL) in measuring cerebral blood flow(CBF) with different post-labeling delay time(PLD) in the resting state and the right finger taping state.Methods 3 D pc-ASL and three dimensional T1-weighted fast spoiled gradient recalled echo(3 D T1-FSPGR) sequence were applied to eight healthy subjects twice at the same time each day for one week interval. ASL data acquisition was performed with post-labeling delay time(PLD) 1.5 seconds and 2.0 seconds in the resting state and the right finger taping state respectively. CBF mapping was calculated and CBF value of both the gray matter(GM) and white matter(WM) was automatically extracted. The reliability was evaluated using the intraclass correlation coefficient(ICC) and Bland and Altman plot.Results ICC of the GM(0.84) and WM(0.92) was lower at PLD 1.5 seconds than that(GM, 0.88; WM, 0.94) at PLD 2.0 seconds in the resting state, and ICC of GM(0.88) was higher in the right finger taping state than that in the resting state at PLD 1.5 seconds. ICC of the GM and WM was 0.71 and 0.78 for PLD 1.5 seconds and PLD 2.0 seconds in the resting state at the first scan, and ICC of the GM and WM was 0.83 and 0.79 at the second scan, respectively.Conclusion This work demonstrated that 3 D pc-ASL might be a reliable imaging technique to measure CBF over the whole brain at different PLD in the resting state or controlled state.
文摘目的比较多参数三维假连续式动脉自旋标记灌注成像(3D p CASL)与动态磁敏感增强灌注成像(DSC PWI)对短暂性脑缺血发作(TIA)责任病灶的检出率。方法比较39例临床诊断TIA患者,并在首次发作24 h内进行磁共振检查。扫描序列包括常规头颅MR成像、MRA(MRA),DWI、3D p CASL(选取两个标记延迟时间post-labeling time,PLD,PLD=1.5 s及PLD=2.5 s),DSC PWI。后处理获取3D p CASL的脑血流(CBF)图像和DSC PWI的Tmax图像。比较不同灌注方法与MRA及DWI结合法对于缺血病灶检出率和缺血面积。结果 TIA患者的缺血病灶检出率,3D p CASL(PLD1.5 s及PLD2.5 s)的CBF图像与DSC PWI Tmax对比无差异;3D p CASL(PLD1.5 s)的CBF图像对于缺血的检出率高于MRA结合DWI法;DSC PWI Tmax、3D p CASL(PLD2.5 s)CBF与MRA结合DWI法无差异。显示低灌注面积,3D p CASL(PLD1.5 s)的CBF图像显示的面积最大,其次是DSC PWI Tmax,而3D p CASL(PLD2.5 s)的CBF图像显示的低灌注面积最小。结论 3D p CASL脑灌注成像技术无创、快速、可重复性强,推荐作为临床可疑TIA患者的影像筛查手段,不同PLD的3D p CASL序列对于病灶的检出及缺血面积的显示有差异,选择较短PLD有可能提高病灶的检出率。
文摘目的:探讨磁共振三维准连续动脉自旋标记(3D-pCASL)成像技术在急性缺血性脑卒中患者中临床诊断中的应用价值。方法:选择61例急性缺血性脑卒中患者,设为观察组;选择同期治疗的59例非急性缺血性脑卒中患者,设为对照组。两组均在完成常规磁共振弥散加权成像(DWI)及3D-pCASL检查;测量病灶及对侧镜像区域脑组织脑血流量(CBF);绘制ROC曲线,分析不同检查方法诊断效能。结果: 61例急性缺血性脑卒中患者最终均得到确诊,患者经3D-pCASL成像技术检测确诊60例,诊断符合率为98.36%( P >0.05);DWI检查确诊58例,诊断符合率95.08%( P >0.05);观察组患者健侧CBF水平与对照组比较,差异无统计学意义( P >0.05);观察组患者患侧CBF水平低于对照组( P <0.05);ROC曲线结果显示:单一DWI、3D-pCASL检查在急性缺血性脑卒中患者中的诊断特异性、敏感性均无统计学意义( P >0.05);DWI及3D-pCASL联合检查在急性缺血性脑卒中患者中的诊断特异性、敏感性,高于单一DWI、3D-pCASL检查( P <0.05)。结论:将3D-pCASL成像技术用于急性缺血性脑卒中患者中效果理想,能实现脑血流量的可视化,弥补传统DWI存在的弊端,为临床诊疗提供可靠的依据和参考。
文摘目的分析肝性脑病(HE)患者脑血流量(CBF)的变化并探讨灌注模式。方法搜集20例经临床检查证实的HE患者和20名健康志愿者纳入本研究,采用3.0 T MRI进行三维准连续动脉自旋标记(3D-pCASL)灌注成像扫描,统计分析患者组(HE组)与正常对照组的脑灌注差异。结果 HE组右侧尾状核头、苍白球、壳核、丘脑、扣带回CBF值分别为(55.65±16.40)、(38.63±7.62)、(52.22±9.77)、(61.31±14.05)、(82.32±16.27)ml·100g^(-1)·min^(-1),左侧尾状核头、苍白球、壳核、丘脑、扣带回CBF值分别为(56.14±17.20)、(36.89±7.94)、(49.54±10.29)、(65.32±13.76)、(84.91±17.39)ml·100g^(-1)·min^(-1),中脑及脑桥CBF值为(48.62±11.23)、(52.43±9.10)ml·100g^(-1)·min^(-1);对照组右侧尾状核头、苍白球、壳核、丘脑、扣带回CBF值分别为(56.46±5.98)、(36.41±4.76)、(45.88±5.88)、(50.27±7.42)、(51.59±6.06)ml·100g^(-1)·min^(-1),左侧尾状核头、苍白球、壳核、丘脑、扣带回CBF值分别为(57.11±9.04)、(34.08±3.92)、(45.65±7.71)、(53.40±7.79)、(55.90±8.08)ml·100g^(-1)·min^(-1),中脑及脑桥CBF值为(42.68±7.18)、(41.21±5.91)ml·100g^(-1)·min^(-1)。与对照组比较,HE组双侧丘脑、扣带回及脑桥的CBF升高,差异均具有统计学意义(P<0.05),双侧尾状核头、苍白球、壳核及中脑的CBF差异无统计学意义(P>0.05)。尾状核头的CBF值与Child-Pugh评分相关(P<0.05),双侧苍白球、壳核、丘脑、扣带回、中脑及脑桥的CBF值均与Child-Pugh评分无关(P>0.05)。结论 3D-pCASL可定量评估HE患者的CBF,HE患者皮质功能不良,CBF由皮质向基底神经节重新分配。
