The China Spallation Neutron Source （CSNS） is an accelerator-based multidisciplinary user facility to be constructed in Dongguan, Guangdong, China. The CSNS complex consists of an H- linear accelerator, a rapid cycl...The China Spallation Neutron Source （CSNS） is an accelerator-based multidisciplinary user facility to be constructed in Dongguan, Guangdong, China. The CSNS complex consists of an H- linear accelerator, a rapid cycling synchrotron accelerating the beam to 1.6 GeV, a solid-tungsten target station, and instruments for spallation neutron applications. The facility operates at 25 Hz repetition rate with an initial design beam power of 120 kW and is upgradeable to 500 kW. Construction of the CSNS project will lay the foundation of a leading national research center based on advanced proton-accelerator technology, pulsed neutron-scattering technology, and related programs including muon, fast neutron, and proton applications as well as medical therapy and accelerator-driven subcritical reactor （ADS） applications to serve China＇s strategic needs in scientific research and technological innovation for the next 30 plus years.展开更多
In order to study the technology on cyclotron design,and to carry out researches on the crucial parts including the main magnet,beam diagnostics and engineering technology to accomplish the experimental verification o...In order to study the technology on cyclotron design,and to carry out researches on the crucial parts including the main magnet,beam diagnostics and engineering technology to accomplish the experimental verification of the 100MeV high intensity cyclotron and to pave the way for further increasing the current of the proton beam,a series of work has been done in succession since 2004,which highlights the research,design and fabrication of some of the critical parts.The technical requirement for each part has been reached consecutively.At present,all the work has been integrated into a set of comprehensive device,CRM Cyclotron,which is actually a test stand for high intensity cyclotron development.This report will lay emphasis on the following:the CRM Cyclotron design and fabrication of relevant equipment,magnetic field mapping and shimming,10—15mA H- ion source,experimental research on RF cavity and injection system,beam commissioning on the internal target system,etc.展开更多
Because of its excellent dose distribution,proton therapy is becoming increasingly popular in the medical application of cancer treatment.A synchrotron-based proton therapy facility was designed and constructed in Sha...Because of its excellent dose distribution,proton therapy is becoming increasingly popular in the medical application of cancer treatment.A synchrotron-based proton therapy facility was designed and constructed in Shanghai.The synchrotron,beam delivery system,and other technical systems were commissioned and reached their expected performances.After a clinical trial of 47 patients was finished,the proton therapy facility obtained a registration certificate from the National Medical Products Administration.The characteristics of the accelerator and treatment systems are described in this article.展开更多
Cone-beam computed tomography(CBCT) is mostly used for position verification during the treatment process. However,severe image artifacts in CBCT hinder its direct use in dose calculation and adaptive radiation therap...Cone-beam computed tomography(CBCT) is mostly used for position verification during the treatment process. However,severe image artifacts in CBCT hinder its direct use in dose calculation and adaptive radiation therapy re-planning for proton therapy. In this study, an improved U-Net neural network named CBAM-U-Net was proposed for CBCT noise reduction in proton therapy, which is a CBCT denoised U-Net network with convolutional block attention modules. The datasets contained 20 groups of head and neck images. The CT images were registered to CBCT images as ground truth. The original CBCT denoised U-Net network, sCTU-Net, was trained for model performance comparison. The synthetic CT(SCT) images generated by CBAM-U-Net and the original sCTU-Net are called CBAM-SCT and U-Net-SCT images, respectively. The HU accuracies of the CT, CBCT, and SCT images were compared using four metrics: mean absolute error(MAE), root mean square error(RMSE), peak signal-to-noise ratio(PSNR), and structure similarity index measure(SSIM). The mean values of the MAE, RMSE, PSNR, and SSIM of CBAM-SCT images were 23.80 HU, 64.63 HU, 52.27 dB, and 0.9919, respectively,which were superior to those of the U-Net-SCT images. To evaluate dosimetric accuracy, the range accuracy was compared for a single-energy proton beam. The γ-index pass rates of a 4 cm × 4 cm scanned field and simple plan were calculated to compare the effects of the noise reduction capabilities of the original U-Net and CBAM-U-Net on the dose calculation results. CBAM-U-Net reduced noise more effectively than sCTU-Net, particularly in high-density tissues. We proposed a CBAM-U-Net model for CBCT noise reduction in proton therapy. Owing to the excellent noise reduction capabilities of CBAM-U-Net, the proposed model provided relatively explicit information regarding patient tissues. Moreover, it maybe be used in dose calculation and adaptive treatment planning in the future.展开更多
The utilization of a proton beam from the China Spallation Neutron Source(CSNS)for producing medical radioisotopes is appealing owing to its high current intensity and high energy.The medical isotope production based ...The utilization of a proton beam from the China Spallation Neutron Source(CSNS)for producing medical radioisotopes is appealing owing to its high current intensity and high energy.The medical isotope production based on the proton beam at the CSNS is significant for the development of future radiopharmaceuticals,particularly for theα-emitting radiopharmaceu-ticals.The production yield and activity of typical medical isotopes were estimated using the FLUKA simulation.The results indicate that the 300-MeV proton beam with a power of 100 kW at CSNS-II is highly suitable for proof-of-principle studies of most medical radioisotopes.In particular,this proton beam offers tremendous advantages for the large-scale production of alpha radioisotopes,such as 225Ac,whose theoretical production yield can reach approximately 57 Ci/week.Based on these results,we provide perspectives on the use of CSNS proton beams to produce radioisotopes for medical applications.展开更多
Two-dimensional(2D)transition metal dichalcogenides(TMDs)are considered to be promising building blocks for the next generation electronic and optoelectronic devices.Various doping schemes and work function engineerin...Two-dimensional(2D)transition metal dichalcogenides(TMDs)are considered to be promising building blocks for the next generation electronic and optoelectronic devices.Various doping schemes and work function engineering techniques have been explored to overcome the intrinsic performance limits of 2D TMDs.However,a reliable and long-time air stable doping scheme is still lacking in this field.In this work,we utilize keV ion beams of H2+to irradiate layered WSe2 crystals and obtain efficient n-type doping effect for all irradiated crystals within a fluence of 1×1014 protons·cm−2(1e14).Moreover,the irradiated WSe2 remains an n-type semiconductor even after it is exposed to ambient conditions for a year.Localized ion irradiation with a focused beam can directly pattern on the sample to make high performance homogenous p-n junction diodes.Raman and photoluminescence(PL)spectra demonstrate that the WSe2 crystal lattice stays intact after irradiation within 1e14.We attribute the reliable electrondoping to the significant increase in Se vacancies after the proton irradiation,which is confirmed by our scanning transmission electron microscope(STEM)results.Our work demonstrates a reliable and long-term air stable n-type doping scheme to realize high-performance electronic TMD devices,which is also suitable for further integration with other 2D devices.展开更多
Subject of the halo-chaos control in beam transport networks （channels） has become a key concerned issue for many important applications of high-current proton beam since 1990＇. In this paper, the magnetic field ad...Subject of the halo-chaos control in beam transport networks （channels） has become a key concerned issue for many important applications of high-current proton beam since 1990＇. In this paper, the magnetic field adaptive control based on the neural network with time-delayed feedback is proposed for suppressing beam halo-chaos in the beam transport network with periodic focusing channels. The envelope radius of high-current proton beam is controlled to reach the matched beam radius by suitably selecting the control structure and parameter of the neural network, adjusting the delayed-time and control coefficient of the neural network.展开更多
The proton beam with energy around 100 MeV has seen wide applications in modern scientific research and in various fields.However,proton sources in China fall short for meeting experimental needs owing to the vast siz...The proton beam with energy around 100 MeV has seen wide applications in modern scientific research and in various fields.However,proton sources in China fall short for meeting experimental needs owing to the vast size and expensive traditional proton accelerators.The Institute of Nuclear Science and Technology of Sichuan University proposed to build a 3 GHz side-coupled cavity linac(SCL)for re-accelerating a 26 MeV proton beam extracted from a CS-30 cyclotron to 120 MeV.We carried out investigations into several vital factors of S-band SCL for proton acceleration,such as optimization of SCL cavity geometry,end cell tuning,and bridge coupler design.Results demonstrated that the effective shunt impedance per unit length ranged from 22.5 to 59.8 MX/m throughout the acceleration process,and the acceleration gradient changed from 11.5 to 15.7 MV/m when the maximum surface electric field was equivalent to Kilpatrick electric field.We obtained equivalent circuit parameters of the biperiodic structures and applied them to the end cell tuning;results of the theoretical analysis agreed well with the 3D simulation.We designed and optimized a bridge coupler based on the previously obtained biperiodic structure parameters,and the field distribution un-uniformness was\1.5%for a two-tank module.The radio frequency power distribution system of the linac was obtained based on the preliminary beam dynamics design.展开更多
Introduction Liver transplantation(LT)is considered as the definitive standard treatment for hepatocellular carcinoma(HCC)with the advantage of addressing both malignancy and the underlying cirrhosis,thus,providing th...Introduction Liver transplantation(LT)is considered as the definitive standard treatment for hepatocellular carcinoma(HCC)with the advantage of addressing both malignancy and the underlying cirrhosis,thus,providing the best overall and recurrence-free survival.Unfortunately,only 20-25%of patients meet the eligibility criteria for LT.展开更多
基金Supported by Chinese Academy of Sciences, Guangdong Provincial Government, Dongguan Municipal Government, CAS Hundred People Initiative (KJCX2-YW-N22)Overseas Outstanding Youth Program of National Natural Science Foundation of China (10628510)
文摘The China Spallation Neutron Source （CSNS） is an accelerator-based multidisciplinary user facility to be constructed in Dongguan, Guangdong, China. The CSNS complex consists of an H- linear accelerator, a rapid cycling synchrotron accelerating the beam to 1.6 GeV, a solid-tungsten target station, and instruments for spallation neutron applications. The facility operates at 25 Hz repetition rate with an initial design beam power of 120 kW and is upgradeable to 500 kW. Construction of the CSNS project will lay the foundation of a leading national research center based on advanced proton-accelerator technology, pulsed neutron-scattering technology, and related programs including muon, fast neutron, and proton applications as well as medical therapy and accelerator-driven subcritical reactor （ADS） applications to serve China＇s strategic needs in scientific research and technological innovation for the next 30 plus years.
文摘In order to study the technology on cyclotron design,and to carry out researches on the crucial parts including the main magnet,beam diagnostics and engineering technology to accomplish the experimental verification of the 100MeV high intensity cyclotron and to pave the way for further increasing the current of the proton beam,a series of work has been done in succession since 2004,which highlights the research,design and fabrication of some of the critical parts.The technical requirement for each part has been reached consecutively.At present,all the work has been integrated into a set of comprehensive device,CRM Cyclotron,which is actually a test stand for high intensity cyclotron development.This report will lay emphasis on the following:the CRM Cyclotron design and fabrication of relevant equipment,magnetic field mapping and shimming,10—15mA H- ion source,experimental research on RF cavity and injection system,beam commissioning on the internal target system,etc.
文摘Because of its excellent dose distribution,proton therapy is becoming increasingly popular in the medical application of cancer treatment.A synchrotron-based proton therapy facility was designed and constructed in Shanghai.The synchrotron,beam delivery system,and other technical systems were commissioned and reached their expected performances.After a clinical trial of 47 patients was finished,the proton therapy facility obtained a registration certificate from the National Medical Products Administration.The characteristics of the accelerator and treatment systems are described in this article.
基金Digital Medical Equipment Research and Development Project,Ministry of Science and Technology,China:The development of Synchrotron-based proton therapy system(2016YFC0105400).
文摘Cone-beam computed tomography(CBCT) is mostly used for position verification during the treatment process. However,severe image artifacts in CBCT hinder its direct use in dose calculation and adaptive radiation therapy re-planning for proton therapy. In this study, an improved U-Net neural network named CBAM-U-Net was proposed for CBCT noise reduction in proton therapy, which is a CBCT denoised U-Net network with convolutional block attention modules. The datasets contained 20 groups of head and neck images. The CT images were registered to CBCT images as ground truth. The original CBCT denoised U-Net network, sCTU-Net, was trained for model performance comparison. The synthetic CT(SCT) images generated by CBAM-U-Net and the original sCTU-Net are called CBAM-SCT and U-Net-SCT images, respectively. The HU accuracies of the CT, CBCT, and SCT images were compared using four metrics: mean absolute error(MAE), root mean square error(RMSE), peak signal-to-noise ratio(PSNR), and structure similarity index measure(SSIM). The mean values of the MAE, RMSE, PSNR, and SSIM of CBAM-SCT images were 23.80 HU, 64.63 HU, 52.27 dB, and 0.9919, respectively,which were superior to those of the U-Net-SCT images. To evaluate dosimetric accuracy, the range accuracy was compared for a single-energy proton beam. The γ-index pass rates of a 4 cm × 4 cm scanned field and simple plan were calculated to compare the effects of the noise reduction capabilities of the original U-Net and CBAM-U-Net on the dose calculation results. CBAM-U-Net reduced noise more effectively than sCTU-Net, particularly in high-density tissues. We proposed a CBAM-U-Net model for CBCT noise reduction in proton therapy. Owing to the excellent noise reduction capabilities of CBAM-U-Net, the proposed model provided relatively explicit information regarding patient tissues. Moreover, it maybe be used in dose calculation and adaptive treatment planning in the future.
基金the National Natural Science Foundation of China(No.12075135)the China Postdoctoral Science Foundation(No.2022M721908).
文摘The utilization of a proton beam from the China Spallation Neutron Source(CSNS)for producing medical radioisotopes is appealing owing to its high current intensity and high energy.The medical isotope production based on the proton beam at the CSNS is significant for the development of future radiopharmaceuticals,particularly for theα-emitting radiopharmaceu-ticals.The production yield and activity of typical medical isotopes were estimated using the FLUKA simulation.The results indicate that the 300-MeV proton beam with a power of 100 kW at CSNS-II is highly suitable for proof-of-principle studies of most medical radioisotopes.In particular,this proton beam offers tremendous advantages for the large-scale production of alpha radioisotopes,such as 225Ac,whose theoretical production yield can reach approximately 57 Ci/week.Based on these results,we provide perspectives on the use of CSNS proton beams to produce radioisotopes for medical applications.
基金The authors acknowledge financial support from NRF CRP on Oxide Electronics on Silicon Beyond Moore(NRF-CRP15-2015-01)the National Natural Science Foundation of China(Nos.U2032147,21872100,and 62004128)+2 种基金Singapore MOE Grant T2EP50220-0001,MOE AcRF Tier 1 Startup grant R-284-000-179-133the Science and Engineering Research Council of A*STAR(Agency for Science,Technology and Research)Singapore,under Grant No.A20G9b0135the Fundamental Research Foundation of Shenzhen(No.JCYJ20190808152607389).
文摘Two-dimensional(2D)transition metal dichalcogenides(TMDs)are considered to be promising building blocks for the next generation electronic and optoelectronic devices.Various doping schemes and work function engineering techniques have been explored to overcome the intrinsic performance limits of 2D TMDs.However,a reliable and long-time air stable doping scheme is still lacking in this field.In this work,we utilize keV ion beams of H2+to irradiate layered WSe2 crystals and obtain efficient n-type doping effect for all irradiated crystals within a fluence of 1×1014 protons·cm−2(1e14).Moreover,the irradiated WSe2 remains an n-type semiconductor even after it is exposed to ambient conditions for a year.Localized ion irradiation with a focused beam can directly pattern on the sample to make high performance homogenous p-n junction diodes.Raman and photoluminescence(PL)spectra demonstrate that the WSe2 crystal lattice stays intact after irradiation within 1e14.We attribute the reliable electrondoping to the significant increase in Se vacancies after the proton irradiation,which is confirmed by our scanning transmission electron microscope(STEM)results.Our work demonstrates a reliable and long-term air stable n-type doping scheme to realize high-performance electronic TMD devices,which is also suitable for further integration with other 2D devices.
基金The project supported by the Key Projects of National Natural Science Foundation of China under Grant No. 70431002 and National Natural Science Foundation of China under Grants Nos. 70371068 and 10247005
文摘Subject of the halo-chaos control in beam transport networks （channels） has become a key concerned issue for many important applications of high-current proton beam since 1990＇. In this paper, the magnetic field adaptive control based on the neural network with time-delayed feedback is proposed for suppressing beam halo-chaos in the beam transport network with periodic focusing channels. The envelope radius of high-current proton beam is controlled to reach the matched beam radius by suitably selecting the control structure and parameter of the neural network, adjusting the delayed-time and control coefficient of the neural network.
基金supported by the National Natural Science Foundation of China(Nos.11375122 and 11875197)
文摘The proton beam with energy around 100 MeV has seen wide applications in modern scientific research and in various fields.However,proton sources in China fall short for meeting experimental needs owing to the vast size and expensive traditional proton accelerators.The Institute of Nuclear Science and Technology of Sichuan University proposed to build a 3 GHz side-coupled cavity linac(SCL)for re-accelerating a 26 MeV proton beam extracted from a CS-30 cyclotron to 120 MeV.We carried out investigations into several vital factors of S-band SCL for proton acceleration,such as optimization of SCL cavity geometry,end cell tuning,and bridge coupler design.Results demonstrated that the effective shunt impedance per unit length ranged from 22.5 to 59.8 MX/m throughout the acceleration process,and the acceleration gradient changed from 11.5 to 15.7 MV/m when the maximum surface electric field was equivalent to Kilpatrick electric field.We obtained equivalent circuit parameters of the biperiodic structures and applied them to the end cell tuning;results of the theoretical analysis agreed well with the 3D simulation.We designed and optimized a bridge coupler based on the previously obtained biperiodic structure parameters,and the field distribution un-uniformness was\1.5%for a two-tank module.The radio frequency power distribution system of the linac was obtained based on the preliminary beam dynamics design.
基金Fundamental Research Program of Shenzhen(SZWD2021007,JCYJ20200109105606426)National Natural Science Foundation of China(92050203)Science and Technology on Plasma Physics Laboratory。
文摘Introduction Liver transplantation(LT)is considered as the definitive standard treatment for hepatocellular carcinoma(HCC)with the advantage of addressing both malignancy and the underlying cirrhosis,thus,providing the best overall and recurrence-free survival.Unfortunately,only 20-25%of patients meet the eligibility criteria for LT.
