Background Glutamic acid decarboxylase antibody （GADA） and protein tyrosine phosphatase antibody （IA-2A） are two major autoantibodies, which exert important roles in the process of type 1 diabetes mellitus （T1D）...Background Glutamic acid decarboxylase antibody （GADA） and protein tyrosine phosphatase antibody （IA-2A） are two major autoantibodies, which exert important roles in the process of type 1 diabetes mellitus （T1D）. Our study aimed to investigate the changes in positivity and titers of GADA and IA-2A during the course of Chinese acute-onset T1D patients and their relationships with clinical features.展开更多
文摘Background Glutamic acid decarboxylase antibody （GADA） and protein tyrosine phosphatase antibody （IA-2A） are two major autoantibodies, which exert important roles in the process of type 1 diabetes mellitus （T1D）. Our study aimed to investigate the changes in positivity and titers of GADA and IA-2A during the course of Chinese acute-onset T1D patients and their relationships with clinical features.
文摘目的探讨蛋白酪氨酸磷酸酶抗体(IA-2A)对成人隐匿性自身免疫性糖尿病(LADA)的诊断价值。方法采用放射配体法检测2 027例初诊2型糖尿病(T2DM)患者的IA-2A和谷氨酸脱羧酶抗体(GAD-Ab),分析IA-2A在初诊T2DM患者中的分布及其与临床特征的关系。结果初诊T2DM患者中IA-2A阳性检出率低于GAD-Ab阳性检出率(2.2% vs 10.6%,P<0.01)。联合GAD-Ab和IA2A检测,可使LADA阳性检出率达11.5%。IA-2A在低体重、低C肽水平患者中阳性检出率高;随着起病年龄增大,IA-2A阳性检出率下降(P<0.05)。与T2DM组比较,单独IA-2A阳性患者使用胰岛素治疗的比例高(P<0.05)。高滴度IA-2A阳性LADA患者具有起病年龄小(P<0.01)、体重轻、高血压比例低、空腹C肽低、合并GAD-Ab阳性和使用胰岛素比例高(P<0.05)等特点。结论 IA-2A检测对LADA具有辅助诊断价值,与GAD-Ab联合检测可提高LADA诊断的敏感性。
