Ⅰ. INTRODUCTIONInsulin is a hormone protein which has been investigated in a very broad and deep scope. On the basis of the abundant knowledge on its structure-function relationship, it has been an important subject ...Ⅰ. INTRODUCTIONInsulin is a hormone protein which has been investigated in a very broad and deep scope. On the basis of the abundant knowledge on its structure-function relationship, it has been an important subject for insulin studies trying to reconstitute novel insulin derivatives with some special biological activities, such as prolonged action, higher potence and lower-antigenicity, by protein engineering so as to be advantageous to the therapeutics of diabetes.展开更多
基金Project supported by a grant of "863" high technology.
文摘Ⅰ. INTRODUCTIONInsulin is a hormone protein which has been investigated in a very broad and deep scope. On the basis of the abundant knowledge on its structure-function relationship, it has been an important subject for insulin studies trying to reconstitute novel insulin derivatives with some special biological activities, such as prolonged action, higher potence and lower-antigenicity, by protein engineering so as to be advantageous to the therapeutics of diabetes.
