Transcranial magnetic stimulation(TMS)is a popular modulatory technique for the noninvasive diagnosis and therapy of neurological and psychiatric diseases.Unfortunately,current modulation strategies are only modestly ...Transcranial magnetic stimulation(TMS)is a popular modulatory technique for the noninvasive diagnosis and therapy of neurological and psychiatric diseases.Unfortunately,current modulation strategies are only modestly effective.The literature provides strong evidence that the modulatory effects of TMS vary depending on device components and stimulation protocols.These differential effects are important when designing precise modulatory strategies for clinical or research applications.Developments in TMS have been accompanied by advances in combining TMS with neuroimaging techniques,including electroencephalography,functional nearinfrared spectroscopy,functional magnetic resonance imaging,and positron emission tomography.Such studies appear particularly promising as they may not only allow us to probe affected brain areas during TMS but also seem to predict underlying research directions that may enable us to precisely target and remodel impaired cortices or circuits.However,few precise modulation strategies are available,and the long-term safety and efficacy of these strategies need to be confirmed.Here,we review the literature on possible technologies for precise modulation to highlight progress along with limitations with the goal of suggesting future directions for this field.展开更多
目的分析听障儿童在人工耳蜗调机前后听觉能力和言语清晰度的变化,强调精准调机的重要性,避免电流刺激量过高。方法患儿人工耳蜗术后开机1年4个月,康复效果欠佳,表现为声音察知好,精准听辨和言语清晰度差,听觉能力评估量表(CAP)为5级,...目的分析听障儿童在人工耳蜗调机前后听觉能力和言语清晰度的变化,强调精准调机的重要性,避免电流刺激量过高。方法患儿人工耳蜗术后开机1年4个月,康复效果欠佳,表现为声音察知好,精准听辨和言语清晰度差,听觉能力评估量表(CAP)为5级,言语可懂度分级量表(SIR)为1级。调机时发现,T值、C值均过高,尤其高频电极,给予精准调机,降低电流刺激量。结果电流刺激量降低后,患儿康复效果进步明显,助听听阈25~30 dB HL,听觉能力评估量表(CAP)达7级,言语可懂度分级量表(SIR)达5级。结论人工耳蜗术后精准及个性化调机至关重要,既要重视刺激量不足,也要避免刺激量过高。展开更多
基金the Chinese Academy of Sciences,Science and Technology Service Network Initiative(KFJ-STS-ZDTP-078)the National Natural Science Foun-dation of China(31620103905)+1 种基金the Science Frontier Program of the Chinese Academy of Sciences(QYZDJ SSW-SMC019)the National Key R&D Program of China(2017YFA0105203)。
文摘Transcranial magnetic stimulation(TMS)is a popular modulatory technique for the noninvasive diagnosis and therapy of neurological and psychiatric diseases.Unfortunately,current modulation strategies are only modestly effective.The literature provides strong evidence that the modulatory effects of TMS vary depending on device components and stimulation protocols.These differential effects are important when designing precise modulatory strategies for clinical or research applications.Developments in TMS have been accompanied by advances in combining TMS with neuroimaging techniques,including electroencephalography,functional nearinfrared spectroscopy,functional magnetic resonance imaging,and positron emission tomography.Such studies appear particularly promising as they may not only allow us to probe affected brain areas during TMS but also seem to predict underlying research directions that may enable us to precisely target and remodel impaired cortices or circuits.However,few precise modulation strategies are available,and the long-term safety and efficacy of these strategies need to be confirmed.Here,we review the literature on possible technologies for precise modulation to highlight progress along with limitations with the goal of suggesting future directions for this field.
文摘目的分析听障儿童在人工耳蜗调机前后听觉能力和言语清晰度的变化,强调精准调机的重要性,避免电流刺激量过高。方法患儿人工耳蜗术后开机1年4个月,康复效果欠佳,表现为声音察知好,精准听辨和言语清晰度差,听觉能力评估量表(CAP)为5级,言语可懂度分级量表(SIR)为1级。调机时发现,T值、C值均过高,尤其高频电极,给予精准调机,降低电流刺激量。结果电流刺激量降低后,患儿康复效果进步明显,助听听阈25~30 dB HL,听觉能力评估量表(CAP)达7级,言语可懂度分级量表(SIR)达5级。结论人工耳蜗术后精准及个性化调机至关重要,既要重视刺激量不足,也要避免刺激量过高。
