对铟锡氧化物ITO(Indium Tin Oxide)纳米粉末的制备方法如均相共沉淀法,水溶液共沉淀法,电解法,溶胶-凝胶法,喷雾燃烧法,喷雾热分解法等以及ITO磁控溅射靶的现有几种制备工艺进行了综合评述。阐述了各种制备工艺过程和工作原理,比较和...对铟锡氧化物ITO(Indium Tin Oxide)纳米粉末的制备方法如均相共沉淀法,水溶液共沉淀法,电解法,溶胶-凝胶法,喷雾燃烧法,喷雾热分解法等以及ITO磁控溅射靶的现有几种制备工艺进行了综合评述。阐述了各种制备工艺过程和工作原理,比较和分析了各工艺方法的优缺点,并提出了制备高品质ITO粉末及ITO靶的努力方向。展开更多
Objective:To analyze the effective components of Chinese medicine(CM)contained in Chaihu Shugan Powder(柴胡疏肝散,CSP)in the treatment of depressive disorders and to predict its anti-depressant mechanism by network ph...Objective:To analyze the effective components of Chinese medicine(CM)contained in Chaihu Shugan Powder(柴胡疏肝散,CSP)in the treatment of depressive disorders and to predict its anti-depressant mechanism by network pharmacology.Methods:Absorption,distribution,metabolism,excretion,and toxicity calculation method was used to screen the active components of CSP.Traditional Chinese Medicine System Pharmacological Database Analysis Platform and text mining tool(GoPuMed database)were used to predict and screen the active ingredients of CSP and anti-depressive targets.Through Genetic Association Database,Therapeutic Target Database,and PharmGkb database targets for depression were obtained.Cytoscape3.2.1 software was used to establish a network map of the active ingredients-targets of CSP,and to analyze gene function and metabolic pathways through Database for Annotation,Visualization and Integrated Discovery and the Omicshare database.Results:The 121 active ingredients and 15 depression-related targets which were screened from the database can exert antidepressant effects by improving the neural plasticity,growth,transfer condition and gene expression of neuronal cell,and the raise of the expression of gap junction protein.The 15 targets passed 14 metabolic pathways,mainly involved in the regulation of neurotransmitters(5-hydroxytryptamine,dopamine and epinephrine),inflammatory mediator regulation of TRP channels,calcium signaling pathway,cyclic adenosine monophosphate signaling pathway and neuroactive ligand-receptor interaction and other signal channels to exert anti-depressant effects.Conclusion:This article reveals the possible mechanism of CSP in the treatment of depression through network pharmacology research,and lays a foundation for further target studies.展开更多
目的:通过网络药理学方法探究逍遥散治疗痤疮的主要活性成分及其作用机制。方法:应用中药系统药理数据库与分析平台(TCMSP)筛选逍遥散中含有的有效成分及其作用靶标,并从基因表达综合数据库(GEO)中提取痤疮相关靶标。使用Cytoscape软件...目的:通过网络药理学方法探究逍遥散治疗痤疮的主要活性成分及其作用机制。方法:应用中药系统药理数据库与分析平台(TCMSP)筛选逍遥散中含有的有效成分及其作用靶标,并从基因表达综合数据库(GEO)中提取痤疮相关靶标。使用Cytoscape软件及其bisogenet插件构建逍遥散治疗痤疮的“化合物-靶点”网络,并绘制药物活性成分-靶蛋白-疾病蛋白质-蛋白质相互作用(PPI)网络,再分次进行拓扑分析,得出核心网络。采用R语言软件中ClusterProfiler数据包对逍遥散的潜在作用基因靶点进行基因本体(Gene Ontology,GO)富集分析和京都基因和基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)富集分析,并进行可视化作图。结果:通过TCMSP,获得了逍遥散有效活性成分161个,潜在作用靶点2619个,与146个痤疮相关靶点的共同靶点为37个,包括PTGS2、CCNA2、CHEK1、NR3C2等,潜在活性成分为木犀草素、槲皮素、异鼠李素等110个。GO和KEGG富集分析结果显示,逍遥散治疗痤疮主要通过脂多糖应答、细菌源性分子应答等作用机制,与肿瘤坏死因子信号通路、IL-17信号通路、P53信号通路、核因子κB信号通路等相关。结论:本研究通过网络药理学的方法验证了逍遥散治疗痤疮的多成分、多靶点、多通路的作用机制特点,简单阐述了逍遥散治疗痤疮潜在有效成分及作用通路,为后续的相关研究提供理论支持。展开更多
Experiments on shaped charge penetration into high and ultrahigh strength steel-fiber reactive powder concrete(RPC) targets were performed in this paper.Results show that the variation of penetration depth and crater ...Experiments on shaped charge penetration into high and ultrahigh strength steel-fiber reactive powder concrete(RPC) targets were performed in this paper.Results show that the variation of penetration depth and crater diameter with concrete strength is different from that of shaped charge penetration into normal strength concrete(NSC).The crater diameter of RPC is smaller than that of NSC penetrated by the shaped charge.The jet particles are strongly disturbed and hardly reach the crater bottom because they pass through the narrow channel formed by jet penetration into the RPC.The effects of radial drift velocity and gap effects of jet particles for a shaped charge penetration into RFC target are discussed.Moreover,a theoretical model is presented to describe the penetration of shaped charge into RPC target.As the concrete strength increases,the penetration resistance increases and the entrance crater diameter decreases.Given the drift velocity and narrow crater channel,the low-velocity jet particles can hardly reach the crater bottom to increase the penetration depth.Moreover,the narrow channel has a stronger interference to the jet particles with increasing concrete strength;hence,the gap effects must be considered.The drift velocity and gap effects,which are the same as penetration resistance,also have significant effects during the process of shaped charge penetration into ultrahigh-strength concrete,The crater profiles are calculated through a theoretical model,and the results are in good agreement with the experiments.展开更多
文摘对铟锡氧化物ITO(Indium Tin Oxide)纳米粉末的制备方法如均相共沉淀法,水溶液共沉淀法,电解法,溶胶-凝胶法,喷雾燃烧法,喷雾热分解法等以及ITO磁控溅射靶的现有几种制备工艺进行了综合评述。阐述了各种制备工艺过程和工作原理,比较和分析了各工艺方法的优缺点,并提出了制备高品质ITO粉末及ITO靶的努力方向。
基金Supported by Jiangsu Administration of Traditional Chinese Medicine(No.YB2015052)Scientific Research Project of Jiangsu Health Commission(No.Z2018005)Jiangsu Provincial Bureau of Traditional Chinese Medicine"Chinese Medicine Encephalopathy"Key Discipline Open Project。
文摘Objective:To analyze the effective components of Chinese medicine(CM)contained in Chaihu Shugan Powder(柴胡疏肝散,CSP)in the treatment of depressive disorders and to predict its anti-depressant mechanism by network pharmacology.Methods:Absorption,distribution,metabolism,excretion,and toxicity calculation method was used to screen the active components of CSP.Traditional Chinese Medicine System Pharmacological Database Analysis Platform and text mining tool(GoPuMed database)were used to predict and screen the active ingredients of CSP and anti-depressive targets.Through Genetic Association Database,Therapeutic Target Database,and PharmGkb database targets for depression were obtained.Cytoscape3.2.1 software was used to establish a network map of the active ingredients-targets of CSP,and to analyze gene function and metabolic pathways through Database for Annotation,Visualization and Integrated Discovery and the Omicshare database.Results:The 121 active ingredients and 15 depression-related targets which were screened from the database can exert antidepressant effects by improving the neural plasticity,growth,transfer condition and gene expression of neuronal cell,and the raise of the expression of gap junction protein.The 15 targets passed 14 metabolic pathways,mainly involved in the regulation of neurotransmitters(5-hydroxytryptamine,dopamine and epinephrine),inflammatory mediator regulation of TRP channels,calcium signaling pathway,cyclic adenosine monophosphate signaling pathway and neuroactive ligand-receptor interaction and other signal channels to exert anti-depressant effects.Conclusion:This article reveals the possible mechanism of CSP in the treatment of depression through network pharmacology research,and lays a foundation for further target studies.
文摘目的:通过网络药理学方法探究逍遥散治疗痤疮的主要活性成分及其作用机制。方法:应用中药系统药理数据库与分析平台(TCMSP)筛选逍遥散中含有的有效成分及其作用靶标,并从基因表达综合数据库(GEO)中提取痤疮相关靶标。使用Cytoscape软件及其bisogenet插件构建逍遥散治疗痤疮的“化合物-靶点”网络,并绘制药物活性成分-靶蛋白-疾病蛋白质-蛋白质相互作用(PPI)网络,再分次进行拓扑分析,得出核心网络。采用R语言软件中ClusterProfiler数据包对逍遥散的潜在作用基因靶点进行基因本体(Gene Ontology,GO)富集分析和京都基因和基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)富集分析,并进行可视化作图。结果:通过TCMSP,获得了逍遥散有效活性成分161个,潜在作用靶点2619个,与146个痤疮相关靶点的共同靶点为37个,包括PTGS2、CCNA2、CHEK1、NR3C2等,潜在活性成分为木犀草素、槲皮素、异鼠李素等110个。GO和KEGG富集分析结果显示,逍遥散治疗痤疮主要通过脂多糖应答、细菌源性分子应答等作用机制,与肿瘤坏死因子信号通路、IL-17信号通路、P53信号通路、核因子κB信号通路等相关。结论:本研究通过网络药理学的方法验证了逍遥散治疗痤疮的多成分、多靶点、多通路的作用机制特点,简单阐述了逍遥散治疗痤疮潜在有效成分及作用通路,为后续的相关研究提供理论支持。
基金supported by the Natural Science Foundation of China through Grant No.11702144。
文摘Experiments on shaped charge penetration into high and ultrahigh strength steel-fiber reactive powder concrete(RPC) targets were performed in this paper.Results show that the variation of penetration depth and crater diameter with concrete strength is different from that of shaped charge penetration into normal strength concrete(NSC).The crater diameter of RPC is smaller than that of NSC penetrated by the shaped charge.The jet particles are strongly disturbed and hardly reach the crater bottom because they pass through the narrow channel formed by jet penetration into the RPC.The effects of radial drift velocity and gap effects of jet particles for a shaped charge penetration into RFC target are discussed.Moreover,a theoretical model is presented to describe the penetration of shaped charge into RPC target.As the concrete strength increases,the penetration resistance increases and the entrance crater diameter decreases.Given the drift velocity and narrow crater channel,the low-velocity jet particles can hardly reach the crater bottom to increase the penetration depth.Moreover,the narrow channel has a stronger interference to the jet particles with increasing concrete strength;hence,the gap effects must be considered.The drift velocity and gap effects,which are the same as penetration resistance,also have significant effects during the process of shaped charge penetration into ultrahigh-strength concrete,The crater profiles are calculated through a theoretical model,and the results are in good agreement with the experiments.
