Objective:To evaluate and compare the effect of semi-rigid ureterorenoscopy on post-procedural sexual function with three different operating room settings.Methods:In this prospective randomized study,consecutive sexu...Objective:To evaluate and compare the effect of semi-rigid ureterorenoscopy on post-procedural sexual function with three different operating room settings.Methods:In this prospective randomized study,consecutive sexually active patients with normal pre-operative sexual function undergoing uncomplicated semi-rigid ureterorenoscopy for distal ureteric stones were randomized into three groups,with three different operating room settings.Procedure-related anxiety and sexual function were assessed pre-operatively using Amsterdam Preoperative Anxiety and Information Scale and Brief Sexual Function Inventory(in males)and Female Sexual Function Index-6(in females),respectively.All the participants were stented following the procedure,and the stent was removed after 3 weeks.Post-procedural sexual function and general discomfort were assessed and compared between three groups at 1 week,3 weeks,and 12 weeks.The effect of surgery-related anxiety,preoperative sexual function,age,and general discomfort(including stent-related discomfort)on post-procedural sexual function were analyzed using multiple regression analysis.A p-value of less than 0.05 was considered statistically significant.Results:Totally,327 eligible patients were randomized into three groups.The group of patients who underwent the procedural with a screen separating the operating area from the patient vision,while the patient could watch the endoscopy through a separate monitor,had better post-procedural sexual function compared to those who had total vision of the operating area as well as to those whose eyes were blocked.This difference was statistically significant.This post-procedural reduction in sexual function could not be attributed to in situ stent alone.Conclusions:Our study showed that semi-rigid ureterorenoscopy can have significant negative effect on sexual function,which can be reduced with proper preoperative counseling and an ideal operating room settings.展开更多
Hyaluronic acid (HA) preparations have emerged as pivotal components in contemporary dentistry, gaining widespread recognition for their multifaceted roles in various biological functions. Extensive literature undersc...Hyaluronic acid (HA) preparations have emerged as pivotal components in contemporary dentistry, gaining widespread recognition for their multifaceted roles in various biological functions. Extensive literature underscores the significance of HA in maintaining tissue water balance, fostering cell proliferation, promoting rapid cell migration, influencing cell differentiation during organism development, and facilitating tissue regeneration. Notably, HA’s interactions with cell surface receptors contribute to the viscosity of synovial fluid, activate the immune system, and enhance cartilage elasticity. Beyond these established functions, HA has also been investigated for its potential involvement in determining and studying the hormetic effects of radon water, adding a novel dimension to its applications in dental research. A thorough exploration of existing studies reveals a nuanced understanding of how HA interventions impact the outcomes of dental procedures. The comprehensive scope of these investigations allows for a more accurate assessment of the potential effectiveness of specific interventions and provides valuable insights into post-procedural prognoses for individual patients. This synthesis of literature serves as the foundation for elucidating the intricate interplay between HA, radon exposure, and their relevance in modern dental practices.展开更多
Objective To evaluate the effects and mechanisms of glucose-insulin-potassium(GIK)on post-procedural myocardial injury(PMI)after percutaneous coronary intervention(PCI).Methods A total of 200 non-diabetic patients wit...Objective To evaluate the effects and mechanisms of glucose-insulin-potassium(GIK)on post-procedural myocardial injury(PMI)after percutaneous coronary intervention(PCI).Methods A total of 200 non-diabetic patients with documented coronary heart disease(CHD)were divided into the Group GIK and Group G,with 100 patients in each group.Patients in Group G were given intravenous infusion of glucose solution 2 hours before PCI.As compared,patients in Group GIK were given GIK.Results Both post-procedural creatine phosphokinase isoenzyme MB(CK-MB;62.1±47.8 vs.48.8±52.6 U/L,P=0.007)and cTnI(0.68±0.83 vs.0.19±0.24 ng/mL,P<0.001)in Group GIK were significantly higher than those in Group G.In Group G,9.0%and 4.0%of patients had post-procedural increases in CK-MB 1-3 times and>3 times,which were significantly lower than those in Group GIK(14.0%and 7.0%,respectively;all P values<0.01);13.0%and 7.0%of patients had post-procedural increases in cTnI 1-3 times and>3 times,which were also significantly lower than those in Group GIK(21.0%and 13.0%,respectively;all P<0.001).Pre-procedural(10.2±4.5 vs.5.1±6.3,P<0.001)and post-procedural rapid blood glucose(RBG)levels(8.9±3.9 vs.5.3±5.6,P<0.001)in Group G were higher than those in Group GIK.In adjusted logistic models,usage of GIK(compared with glucose solution)remained significantly and independently associated with higher risk of post-procedural increases in both CK-MB and cTnI levels>3 times.Furthermore,pre-procedural RBG levels<5.0mmol/L were significantly associated with higher risk of post-procedural increases in both CK-MB and cTnI levels.Conclusions In non-diabetic patients with CHD,the administration of GIK may increase the risk of PMI due to hypoglycemia induced by GIK.展开更多
目的·比较0.014 in的Synchro微导丝和Transend微导丝对急性缺血性脑卒中支架取栓的速度及安全性的影响。方法·入组2012年10月至2017年1月在上海交通大学医学院附属第九人民医院接受机械取栓的急性缺血性卒中患者46例,分为Sync...目的·比较0.014 in的Synchro微导丝和Transend微导丝对急性缺血性脑卒中支架取栓的速度及安全性的影响。方法·入组2012年10月至2017年1月在上海交通大学医学院附属第九人民医院接受机械取栓的急性缺血性卒中患者46例,分为Synchro组(21例)和Transend组(25例),比较2组手术操作时间及安全性等指标。结果·2组闭塞血管再通率类似(P=0.600),但Synchro组从股动脉穿刺至血管再通时间显著短于Transend组(48.88 min vs 82.33 min,P=0.001)。2组患者术后3个月获得功能独立(mRS≤2)的比例类似(P=1.000),操作后蛛网膜下腔出血发生率类似(P=1.000)。但Transend组有2例因血管穿孔导致严重蛛网膜下腔出血伴血肿,均死亡;Synchro组仅有1例轻微的单纯蛛网膜下腔出血,恢复良好。结论·和Transend微导丝相比,Synchro微导丝能够缩短支架取栓操作时间,致命性蛛网膜下腔出血风险较小。展开更多
Recently, some new quadrilateral finite elements were successfully developed by the Quadrilateral Area Coordinate （QAC） method. Compared with those traditional models using isoparametric coordinates, these new model...Recently, some new quadrilateral finite elements were successfully developed by the Quadrilateral Area Coordinate （QAC） method. Compared with those traditional models using isoparametric coordinates, these new models are less sensitive to mesh distortion. In this paper, a new displacement-based, 4-node 20-DOF （5-DOF per node） quadrilateral bending element based on the first-order shear deformation theory for analysis of arbitrary laminated composite plates is presented. Its bending part is based on the element AC-MQ4, a recent-developed high-performance Mindlin-Reissner plate element formulated by QAC method and the generalized conforming condition method; and its in-plane displacement fields are interpolated by bilinear shape functions in isoparametric coordinates. Furthermore, the hybrid post-rocessing procedure, which was firstly proposed by the authors, is employed again to improve the stress solutions, especially for the transverse shear stresses. The resulting element, denoted as AC-MQ4-LC, exhibits excellent performance in all linear static and dynamic numerical examples. It demonstrates again that the QAC method, the generalized conforming condition method, and the hybrid post-processing procedure are efficient tools for developing simple, effective and reliable finite element models.展开更多
文摘Objective:To evaluate and compare the effect of semi-rigid ureterorenoscopy on post-procedural sexual function with three different operating room settings.Methods:In this prospective randomized study,consecutive sexually active patients with normal pre-operative sexual function undergoing uncomplicated semi-rigid ureterorenoscopy for distal ureteric stones were randomized into three groups,with three different operating room settings.Procedure-related anxiety and sexual function were assessed pre-operatively using Amsterdam Preoperative Anxiety and Information Scale and Brief Sexual Function Inventory(in males)and Female Sexual Function Index-6(in females),respectively.All the participants were stented following the procedure,and the stent was removed after 3 weeks.Post-procedural sexual function and general discomfort were assessed and compared between three groups at 1 week,3 weeks,and 12 weeks.The effect of surgery-related anxiety,preoperative sexual function,age,and general discomfort(including stent-related discomfort)on post-procedural sexual function were analyzed using multiple regression analysis.A p-value of less than 0.05 was considered statistically significant.Results:Totally,327 eligible patients were randomized into three groups.The group of patients who underwent the procedural with a screen separating the operating area from the patient vision,while the patient could watch the endoscopy through a separate monitor,had better post-procedural sexual function compared to those who had total vision of the operating area as well as to those whose eyes were blocked.This difference was statistically significant.This post-procedural reduction in sexual function could not be attributed to in situ stent alone.Conclusions:Our study showed that semi-rigid ureterorenoscopy can have significant negative effect on sexual function,which can be reduced with proper preoperative counseling and an ideal operating room settings.
文摘Hyaluronic acid (HA) preparations have emerged as pivotal components in contemporary dentistry, gaining widespread recognition for their multifaceted roles in various biological functions. Extensive literature underscores the significance of HA in maintaining tissue water balance, fostering cell proliferation, promoting rapid cell migration, influencing cell differentiation during organism development, and facilitating tissue regeneration. Notably, HA’s interactions with cell surface receptors contribute to the viscosity of synovial fluid, activate the immune system, and enhance cartilage elasticity. Beyond these established functions, HA has also been investigated for its potential involvement in determining and studying the hormetic effects of radon water, adding a novel dimension to its applications in dental research. A thorough exploration of existing studies reveals a nuanced understanding of how HA interventions impact the outcomes of dental procedures. The comprehensive scope of these investigations allows for a more accurate assessment of the potential effectiveness of specific interventions and provides valuable insights into post-procedural prognoses for individual patients. This synthesis of literature serves as the foundation for elucidating the intricate interplay between HA, radon exposure, and their relevance in modern dental practices.
基金The report was supported by grants from the Beijing Nova Program(No.Z121107002512053)the Beijing Health System High Level Health Technology Talent Cultivation Plan(No.2013-3-013)+3 种基金Beijing Outstanding Talent Training Program(No.2014000021223ZK32)the National Natural Science Foundation of China(No.81100143)the Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support(No.ZYLX 201303)and the National Key Clinical Speciality Construction Project.
文摘Objective To evaluate the effects and mechanisms of glucose-insulin-potassium(GIK)on post-procedural myocardial injury(PMI)after percutaneous coronary intervention(PCI).Methods A total of 200 non-diabetic patients with documented coronary heart disease(CHD)were divided into the Group GIK and Group G,with 100 patients in each group.Patients in Group G were given intravenous infusion of glucose solution 2 hours before PCI.As compared,patients in Group GIK were given GIK.Results Both post-procedural creatine phosphokinase isoenzyme MB(CK-MB;62.1±47.8 vs.48.8±52.6 U/L,P=0.007)and cTnI(0.68±0.83 vs.0.19±0.24 ng/mL,P<0.001)in Group GIK were significantly higher than those in Group G.In Group G,9.0%and 4.0%of patients had post-procedural increases in CK-MB 1-3 times and>3 times,which were significantly lower than those in Group GIK(14.0%and 7.0%,respectively;all P values<0.01);13.0%and 7.0%of patients had post-procedural increases in cTnI 1-3 times and>3 times,which were also significantly lower than those in Group GIK(21.0%and 13.0%,respectively;all P<0.001).Pre-procedural(10.2±4.5 vs.5.1±6.3,P<0.001)and post-procedural rapid blood glucose(RBG)levels(8.9±3.9 vs.5.3±5.6,P<0.001)in Group G were higher than those in Group GIK.In adjusted logistic models,usage of GIK(compared with glucose solution)remained significantly and independently associated with higher risk of post-procedural increases in both CK-MB and cTnI levels>3 times.Furthermore,pre-procedural RBG levels<5.0mmol/L were significantly associated with higher risk of post-procedural increases in both CK-MB and cTnI levels.Conclusions In non-diabetic patients with CHD,the administration of GIK may increase the risk of PMI due to hypoglycemia induced by GIK.
文摘目的·比较0.014 in的Synchro微导丝和Transend微导丝对急性缺血性脑卒中支架取栓的速度及安全性的影响。方法·入组2012年10月至2017年1月在上海交通大学医学院附属第九人民医院接受机械取栓的急性缺血性卒中患者46例,分为Synchro组(21例)和Transend组(25例),比较2组手术操作时间及安全性等指标。结果·2组闭塞血管再通率类似(P=0.600),但Synchro组从股动脉穿刺至血管再通时间显著短于Transend组(48.88 min vs 82.33 min,P=0.001)。2组患者术后3个月获得功能独立(mRS≤2)的比例类似(P=1.000),操作后蛛网膜下腔出血发生率类似(P=1.000)。但Transend组有2例因血管穿孔导致严重蛛网膜下腔出血伴血肿,均死亡;Synchro组仅有1例轻微的单纯蛛网膜下腔出血,恢复良好。结论·和Transend微导丝相比,Synchro微导丝能够缩短支架取栓操作时间,致命性蛛网膜下腔出血风险较小。
基金The project is supported by the National Natural Science Foundation of China(10502028)the Special Foundation for the Authors of the Nationwide(China)Excellent Doctoral Dissertation(200242)the Science Research Foundation of China Agricultural University(2004016).
文摘Recently, some new quadrilateral finite elements were successfully developed by the Quadrilateral Area Coordinate （QAC） method. Compared with those traditional models using isoparametric coordinates, these new models are less sensitive to mesh distortion. In this paper, a new displacement-based, 4-node 20-DOF （5-DOF per node） quadrilateral bending element based on the first-order shear deformation theory for analysis of arbitrary laminated composite plates is presented. Its bending part is based on the element AC-MQ4, a recent-developed high-performance Mindlin-Reissner plate element formulated by QAC method and the generalized conforming condition method; and its in-plane displacement fields are interpolated by bilinear shape functions in isoparametric coordinates. Furthermore, the hybrid post-rocessing procedure, which was firstly proposed by the authors, is employed again to improve the stress solutions, especially for the transverse shear stresses. The resulting element, denoted as AC-MQ4-LC, exhibits excellent performance in all linear static and dynamic numerical examples. It demonstrates again that the QAC method, the generalized conforming condition method, and the hybrid post-processing procedure are efficient tools for developing simple, effective and reliable finite element models.
